CAS: 4052-30-6; 4-Methylsulfonylbenzoic Acid

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CAS号3446-89-7 甲硫基苯甲醛 | CAS号13205-48-6 4-甲硫基苯甲酸 | CAS号3446-90-0 4-甲硫基苄醇 | CAS号623-13-2 1-甲基-4-甲硫基苯 | CAS号22821-77-8 4-甲砜基苯甲醇 | CAS号3185-99-7 对甲砜基甲苯 | CAS号22821-76-7 4-甲砜基苯腈 | CAS号10130-89-9 4-氯磺酰基苯甲酸 | CAS号79-11-8 氯乙酸 | CAS号20884-78-0 N,N-Diethyl-p-(... | CAS号53606-06-7 4-甲基磺酰苄溴 | CAS号1280729-47-6 (4-chloro-2,5-d... | CAS号3112-85-4 甲基苯基砜 | CAS号22821-76-7 4-甲砜基苯腈 | CAS号17574-50-4 4-甲砜基苯脒 | CAS号22821-70-1 4-甲磺酰基苯甲酸甲酯 | CAS号22821-77-8 4-甲砜基苯甲醇 | CAS号20884-77-9 N-Isopropyl-p-(... | CAS号77502-35-3 1,2-Bis(4-(4-me...

4-甲基磺酰苯酚置于锰,Bis(Triphenylphosphine)Nickel(II) Chloride,硫酰氟,新铜试剂,三乙胺体系中,用 1,4-二氧六环,N,N-二甲基甲酰胺 作为反应溶剂,20.0 °C,101.33 Kpa 条件下,反应 44.0H,反应生成 4-甲砜基苯甲酸
参考文献:使用二氧化碳的镍催化芳基和杂芳基氟代硫酸盐的羧化反应
标题:使用二氧化碳的镍催化芳基和杂芳基氟代硫酸盐的羧化反应
摘要:利用co 2作为c1合成子来构建羧酸的有效且实用的方法的开发非常重要.描述了用co 2进行镍催化的芳基氟代硫酸盐和杂芳基氟代硫酸盐的羧化,在温和条件下提供芳烃羧酸,具有非常好的产率或优异的产率.另外,开发了一种单锅酚氟代硫酸化/羧化.
DOI:10.1021/acs.Orglett.9B00836

专利信息

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:CN-112300033-B
优先权日:2020-11-03
标题:A device and synthesis method for fully continuous synthesis of 2-nitro-4-methylsulfonyl benzoic acid from 4-methylsulfonyltoluene

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:CN-112300033-A
优先权日:2020-11-03
标题 :A kind of 4-methylsulfonyltoluene fully continuous synthesis device and synthesis method of 2-nitro-4-methylsulfonylbenzoic acid

专利号:US-2004106598-A1
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting Beta-amyloid peptide release and/or its synthesis by use of such compounds