专利号:US-7557099-B2 优先权日:2004-03-01 标题 :Pyrrolobenzodiazepines as key intermediates in the synthesis of dimeric cytotoxic pyrrolobenzodiazepines 发明人:HOWARD PHILIP WILSON; KANG GYOUNG-DONG 权利人:SPIROGEN LTD 摘要:Compounds and a method of synthesis of compounds of formula (Ia) or (Ib): and salts, solvates, and chemically protected forms thereof, wherein the dotted lines indicate the optional presence of a double bond between C1 and C2 or C2 and C3; R 2 and R 3 are independently selected from —H, â•?O, â•?CH 2 , —CN, —R, OR, halo, â•?CH—R, O—SO 2 —R, CO 2 R and COR; R 10 is a carbamate-based nitrogen protecting group; and R 11 is an oxygen protecting group.
专利号:US-2009111737-A1 优先权日:1999-05-24 标题:Novel antibacterial agents 发明人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES 权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES 摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.
专利号:US-8968421-B2 优先权日:2011-10-14 标题:Synthesis and application reactive antimicrobial copolymers for textile fibers 发明人:LOCKLIN JASON J 权利人:UNIV GEORGIA; UNIV GEORGIA 摘要:Polymer compositions, methods of making polymer compositions, structures (e.g., textile articles) having the polymer composition covalently bonded to the structure, methods of attaching the polymer to the surface of the structure having —OH functionality (e.g., C alkyl —OH), methods of decreasing the amount of microorganisms formed on a structure, and the like, are provided herein.
专利号:US-9006467-B2 优先权日:2011-02-14 标题:1,2,3-triazole containing artemisinin compounds and process for preparation thereof 发明人:SAIKIA BISHWAJIT; BARUA NABIN C; SAIKIA PARTHA P; GOSWAMI ABHISHEK; RAO PARUCHURI G; SAXENA AJIT K; SURI NITASHA 权利人:SAIKIA BISHWAJIT; BARUA NABIN C; SAIKIA PARTHA P; GOSWAMI ABHISHEK; RAO PARUCHURI G; SAXENA AJIT K; SURI NITASHA; COUNCEL OF SCIENT & IND RES 摘要:The present invention relates to 1,2,3-triazole containing artemisinin compounds and process for preparation thereof. Described herein is the synthesis, bioassay results and usefulness of the artemisinin derived compounds resulting from 1,3-dipolar cycloaddition reaction of artemisinin derived azide or alkyne with aliphatic or aromatic diazides. These 1,2,3-triazole containing artemisinin derived compounds embodied in this document are found to be active against various cancer cell-lines.
专利号:US-8876914-B2 优先权日:2010-04-26 标 题:Synthesis and application reactive antimicrobial copolymers for textile fibers 发明人:LOCKLIN JASON J 权利人:LOCKLIN JASON J; UNIV GEORGIA 摘要:Embodiments of the present disclosure provide polymer compositions, methods of making polymer compositions, structures (e.g., textile articles) having the polymer composition covalently bonded to the structure, methods of attaching the polymer to the surface of the structure, methods of decreasing the amount of microorganisms formed on a structure, and the like.
专利号:US-2007191309-A1 优先权日:2004-03-01 标题 :Pyrrolobenzodiazepines as key intermediates in the synthesis of dimeric cytotoxic pyrrolobenzodiazepines
参考标题:Synthesis Of Bivalent Organophosphorus Compounds As Acetylcholinesterase Inhibitors 作者:Guoquan Yang,Qianfei Zhao,Yonghong Li,Huizhu Yuan,Xiangdong Mei,Jun Ning |发布日期:2008.10 摘要:Glu199, Asp-276 And The Hydrophobic Residues Lining The Entrance Gorge Of Ache Through Binding To Both Catalytic And Peripheral Sites Of The Enzyme, A New Series Of Dual Binding Site Ache Inhibitors Have Been Designed And Synthesized.1° The Cluster Effect, Combined With Information About The Structure Of Acetylcholinesterase, Led Us To Design And Synthesize Some Bivalent Organphosphorus Compounds As
合成参考文献
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