CAS: 584-74-7; Ethyl 2-Fluorophenylacetate

该化合物是一种有机化合物,其特性为酯性功能组,来源于乙醇和二氟苯乙酸的反应,该化合物一般看起来无色可粉黄,具有美味的果味;乙基-2-氟苯乙酸以有机溶剂中的中溶性而闻名,但因其疏水性而较少溶于水中;在合成各种药品和农用化学品时,以及因其芳香特性而应用于香味工业中;氟原子在其结构中的存在可影响其再活性和生物活动,使其成为医药化学的一个对象;与许多有机化合物一样,在处理乙基-2-氟乙酸酯时应采取安全防范措施,因为如吸入或摄入,可能会对健康造成危害;应当采用适当的储存和处置方法,以减轻环境影响.

英文名称Ethyl 2-Fluorophenylacetate
中文名称2-(2-氟苯基)乙酸乙酯
IUPAC名称ethyl 2-(2-fluorophenyl)acetate
其它别名2-氟苯基乙酸乙酯; Ethyl 2-Fluorophenylacetate
CAS编号584-74-7
MFCD编号:MFCD04039343
EINECS号:639-307-5
分子式:C10H11FO2
分子量:182.19
产品CID: 1559466
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
产品信息参考;;;;
InChIKey: OFWMNCYZASDVSS-UHFFFAOYSA-N
InChI=1S/C10H11FO2/c1-2-13-10(12)7-8-5-3-4-6-9(8)11/h3-6H,2,7H2,1H3…
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数3.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
严重眼刺激类别2
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
安全声明26-36
危险类别码R36/38

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

2-氟苯基乙腈置于sodium Hydroxide体系中,用乙醇作为反应溶剂,化学反应生成 2-氟苯基乙酸乙酯
参考文献:De Burgh Norfolk,S.; Taylor,R.,Journal Of The Chemical Society. Perkin Transactions Ii,1976,P. 280-285
标题:De Burgh Norfolk,S.; Taylor,R.,Journal Of The Chemical Society. Perkin Transactions Ii,1976,P. 280-285

海关参考信息

2902600000-乙苯
2909110000-乙醚
2912110000-甲醛
2912120000-乙醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2006241298-A1
优先权日:2005-04-21
标题:Methods for synthesis of dicarbamate compounds and intermediates in the formation thereof
发明人：MORTKO HENRY; HE WEIXUAN; ANDERSEN MARC W; DOTSE ANTHONY K; LI JIE
权利人:MORTKO HENRY; HE WEIXUAN; ANDERSEN MARC W; DOTSE ANTHONY K; LI JIE
摘要:Disclosed is a method of making 2-substituted-2-halo-1,3-propanediols via reduction of corresponding malonate compounds. Also disclosed is a method of making 2-substituted-2-halo-1,3-dicarbamate compounds (such as halo derivatives of felbamate, including fluorofelbamate) via reduction of malonate compounds, followed by carbamoylation. Reduction of the malonate compounds is carried out using an electrophilic hydride reagent.

专利号:EP-1888570-A2
优先权日:2005-04-21
标题 :Methods for synthesis of dicarbamate compounds and intermediates in the formation thereof

专利号:EP-3929197-B1
优先权日:2015-08-12
标题:Intermediates for the synthesis of microbiocidal heterobicyclic derivatives

专利号:US-6992097-B2
优先权日:1998-08-18
标题 :Growth hormone secretagogues
发明人：HAUSER KENNETH LEE; DODGE JEFFREY ALAN; HEIMAN MARK LOUIS; JONES SCOTT ALAN; ALT CHARLES ARTHUR; BRYANT HENRY UHLMAN; COHEN JEFFREY DANIEL; COPP JAMES DENSMORE; FAHEY KENNAN JOSEPH; GRITTON WILLIAM HARLAN; JUNGHEIM LOUIS NICKOLAUS; KENNEDY JOSEPH HENRY; LUGAR III CHARLES WILLIS; MUEHL BRIAN STEPHEN; PALKOWITZ ALAN DAVID; RATZ ANDREW MICHAEL; RHODES GARY ANTHONY; ROBEY ROGER LEWIS; SEYLER DAVID EDWARD; SHEPHERD TIMOTHY ALAN; THRASHER KENNETH JEFF; TRANKLE WILLIAM GEORGE
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:ES-2987575-T3
优先权日:2015-08-12
标题:Intermediates for the synthesis of microbicidal heterobicyclic derivatives

专利号:EP-3929197-A1
优先权日:2015-08-12
标题:Intermediates for the synthesis of microbiocidal heterobicyclic derivatives