CAS: 6200-60-8; Imidazo[1,2-A]Pyridine-3-Carboxylic Acid

相似化合物

6188-43-8 123531-52-2 30489-43-1

上下游产品

CAS号504-29-0 2-氨基吡啶 | CAS号123531-52-2 咪唑[1,2-A]吡啶-3-甲酸乙酯 | CAS号274-76-0 咪唑并[1,2-a]吡啶 | CAS号92961-15-4 3-苯基咪唑并[1,2-a]吡啶

咪唑并[1,2-A]吡啶-3-甲酸乙酯置于lithium Hydroxide Monohydrate体系中,用 四氢呋喃,甲醇,水 作为反应溶剂,化学反应生成 咪唑并[1,2-A]吡啶-3-甲酸
参考文献:通过取代铰链结合剂部分发现有效的集落刺激因子1受体抑制剂
标题:通过取代铰链结合剂部分发现有效的集落刺激因子1受体抑制剂
摘要:肿瘤相关的巨噬细胞(tam)主要与肿瘤的生长有关.集落刺激因子1受体(csf1R)充当tam存活和分化的关键调节剂,并且是癌症治疗的分子靶标.本文中,通过铰链结合部分的替代策略鉴定了新型csf1R抑制剂.咪唑并[1,2-A]吡啶(49)或吡唑并[1,5-A]吡啶(50)作为铰链粘合剂的引入在酶法测定中对csf1R在10 Nm抑制率分别为87%和82%. Ic 50在mnfs60单元中分别为25 Nm和27 Nm的值.这些衍生物显着抑制细胞中的csf1R磷酸化.我们的方法可以用作发现新型激酶抑制剂的策略.
DOI:10.1016/j.Ejmech.2021.113298

专利信息

专利号:US-8318928-B2
优先权日:2008-12-15
标题 :Fused imidazole carboxamides as TRPV3 modulators
发明人：CHAUDHARI SACHIN SUNDARLAL; ABRAHAM THOMAS; KADAM ASHOK BHAUSAHEB; DHONE SACHIN VASANTRAO; KADAM SURESH MAHADEV; KHAIRATKAR-JOSHI NEELIMA; KATTIGE VIDYA GANAPATI
权利人:CHAUDHARI SACHIN SUNDARLAL; ABRAHAM THOMAS; KADAM ASHOK BHAUSAHEB; DHONE SACHIN VASANTRAO; KADAM SURESH MAHADEV; KHAIRATKAR-JOSHI NEELIMA; KATTIGE VIDYA GANAPATI; GLENMARK PHARMACEUTICALS SA
摘要:The present invention provides transient receptor potential vanilloid (TRPV) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.

专利号:CN-104650078-A
优先权日:2015-01-30
标 题:Synthesis method of 6-bromo-imidazo[1,2-a]pyridine-8-methanoic acid