专利号:US-7576234-B2 优先权日:2002-05-15 标题 :Synthesis of 2-alkyl amino acids 发明人:CHORGHADE MUKUND S; GURJAR MUKUND K; MOHAPATRA DEBENDRA K 权利人:GENZYME CORP 摘要:Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. A method of preparing a 2-alkyl amino acid involves a Michael-type addition of a nucleophile to a dialkyl 2-methylidenylpropan-1,3-dioate and the conversion of a ester moiety into an amino moiety. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, an aryl nitrile or imidate is condensed with cysteine, a 2-alkyl cysteine, or a cysteine ester.
专利号:US-9637507-B2 优先权日:2012-11-14 标 题:Process for the preparation of liquid tin(II) alkoxides 发明人:MEEPOWPAN PUTTINAN; PUNYODOM WINITA; MOLLOY ROBERT 权利人:CHIANG MAI UNIV 摘要:A synthetic process of producing liquid tin(II) alkoxides for use as either catalysts in the synthesis of lactide or as initiators in the polymerization of cyclic ester monomers to yield biodegradable polyesters is described. The synthetic process employs anhydrous tin(II) chloride dissolved in n-heptane mixed with dry diethylamine. Alcohols, ROH, in which the R groups are n-C 4 H 9 , n-C 6 H 13 , and n-C 8 H 17 are added to the reaction mixture and stirred for 12 hours. The reaction mixture is then filtered under nitrogen or argon before being evaporated to dryness to yield the three tin(II) alkoxides, namely: tin(II) n-butoxide, tin(II) n-hexoxide, and tin(II) n-octoxide. All three tin(II) alkoxides are viscous, dark yellow liquids which are highly soluble in most common organic solvents. Furthermore, they can all be stored under an inert atmosphere for long periods without any significant change in their reactivity and, therefore, in their effectiveness as catalysts/initiators.
专利号:US-2010093880-A1 优先权日:2006-12-20 标 题:Recycling cleavage of polyurethanes 发明人:BERGFELD MANFRED; KIEFFER ANDREAS 权利人:BERGFELD MANFRED; KIEFFER ANDREAS 摘要:A process is described for splitting polyurethanes and polyurethaneureas, in which the polymer is first reacted with gaseous or liquid secondary aliphatic or cycloaliphatic amines, the secondary urea formed, after removal with hydrogen chloride, is split to the isocyanate, and the polyols or polyamines also formed in the reaction are worked up and purified. It is possible by the process according to the invention to work up polyurethanes, polyurethaneureas, etc., of any origin, and to break them down into the starting materials, specifically the isocyanates, polyols or polyamines, to form starting materials in very high quality, which can be reused for the synthesis of any polyurethanes or polyureas. The invention further provides for the preparation of secondary bis-ureas from polyurethanes or polyurethaneureas or/and ureas.
专利号:WO-2009140467-A1 优先权日:2008-05-15 标 题:Oxobenzindolizinoquinolines and uses thereof 发明人:CUSHMAN MARK S; CINELLI MARIS A; MORRELL ANDREW E; POMMIER YVES G 权利人:PURDUE RESEARCH FOUNDATION; CUSHMAN MARK S; US GOV HEALTH & HUMAN SERV; CINELLI MARIS A; MORRELL ANDREW E; POMMIER YVES G 摘要:The synthesis of aromathecins, substituted 12 H -5,l la-diazadibenzo[ b,h ]fluoren- 11 -ones is described. Use of these cytotoxic compounds and pharmaceutical compositions containing them for the treatment of cancer is described. Two novel processes for the synthesis of this system and a series of 14-substituted aromathecins as novel cytotoxic, topoisomerase I poisons are described.
专利号:US-2003236435-A1 优先权日:2002-05-15 标题 :Synthesis of 2-alkylcysteine via substituted thiazoline ester
专利号:US-2004082796-A1 优先权日:2002-05-15 标 题 :Synthesis of substituted thiazoline carboxylic acids
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合成参考文献
摘要:Pajkert, R.; Röschenthaler, G.-V., Science of Synthesis Knowledge Updates, (2022) 1, 369. 摘要:Gigiena i Sanitariya. For English translation, see HYSAAV., 49(1)(71), 1984 摘要:Sharma, U.; Parmar, D.; Sumit; Manisha, Science of Synthesis: Knowledge Updates, (2024) 2, 10.