CAS: 67625-37-0; Ethyl 6-Bromoimidazo[1,2-A]Pyridine-2-Carboxylate

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749849-14-7 885276-09-5 136117-71-0

上下游产品

5-bromo-2-pyridylamine ethyl Bromopyruvatepyridine6-bromo-2-hydroxymethylimidazo1,2-apyridine 6-bromo-imidazo[1,2-a]pyridine-2-carbohydrazide 6-bromoimidazo[1,2-a]pyridine-2-carboxylic acid ethyl 6-(4-chlorophenyl)imidazo[1,2-a]pyridine-2-carboxylate

2-氨基-5-溴吡啶,3-溴丙酮酸乙酯置于碳酸氢钠体系中,用 乙醇 作为反应溶剂,化学反应 8.0H,以80.6%的收率获得产物6-溴咪唑并[1,2-A]吡啶-2-羧酸乙酯
参考文献:一种新化合物 6-(2-氟苯基)-N-(对甲苯基)Imidazo[1,2-A]Pyridine-2-Carboxamide 的合成,晶体结构和 Dft 研究
标题:一种新化合物 6-(2-氟苯基)-N-(对甲苯基)Imidazo[1,2-A]Pyridine-2-Carboxamide 的合成,晶体结构和 Dft 研究
摘要:6-(2-氟苯基)-N-(对甲苯基)咪唑并[1,2-A]吡啶-2-甲酰胺是一种具有氮杂双环和酰胺基团功能的有机中间体.本文通过闭环反应,铃木反应,水解和酰胺化反应得到标题化合物.化合物的结构通过ft-Ir,1H NMR,13C NMR光谱和ms确认.同时,标题化合物的单晶通过 X 射线衍射测量并进行晶体学和构象分析.使用密度泛函理论 (Dft) 进一步计算分子结构,并与 X 射线衍射值进行比较.构象分析结果表明,Dft优化的分子结构与单晶x射线衍射确定的晶体结构一致.此外,
DOI:10.1134/s0022476619120072

专利信息

专利号:WO-2011050245-A1
优先权日:2009-10-23
标 题:Bicyclic heteroaryls as kinase inhibitors
发明人：FENG YANGBO; CHEN YEN TING; SESSIONS HAMPTON; MISHRA JITENDRA K; CHOWDHURY SARWAT; YIN YAN; LOGRASSO PHILIP; LUO JUN-LI; BANNISTER THOMAS; SCHROETER THOMAS
权利人:FENG YANGBO; CHEN YEN TING; SESSIONS HAMPTON; MISHRA JITENDRA K; CHOWDHURY SARWAT; YIN YAN; LOGRASSO PHILIP; LUO JUN-LI; BANNISTER THOMAS; SCHROETER THOMAS
摘要:The invention is directed to heteroaryl compounds useful as inhibitors of various kinase enzymes. In various embodiments, the invention provides a heteroaryl compound having inhibitory bioactivity with respect to a Rho kinase, an AKT kinase, a p70S6K kinase, a LIM kinase, an IKK kinase, a Flt kinase, an Aurora kinase, or a Src kinase, or any combination thereof. Compounds of the invention include bicyclic heteroaryl compounds of formula (I), which can contain a bridging nitrogen atom at a ring junction. The invention further provides methods of synthesis of compounds of the invention, pharmaceutical compositions, pharmaceutical combinations, and methods of treatment of malconditions using compounds of the invention.