CAS: 10310-21-1; 2-Amino-6-Chloropurine

相似化合物

130120-68-2 309947-89-5 10310-21-1

上下游产品

CAS号73-40-5 鸟嘌呤 | CAS号3056-33-5 二乙酰鸟嘌呤 | CAS号190962-00-6 6-chloro-2-form... | CAS号97965-44-1 N-(9-acetyl-6-c... | CAS号149948-29-8 N'-(6-chloro-7H... | CAS号105797-60-2 6-(2-methoxyeth... | CAS号35109-88-7 2-碘腺苷 | CAS号39809-25-1 喷昔洛韦 | CAS号374750-30-8 2'-C-甲基鸟苷 | CAS号149376-70-5 2-氨基-6-氯-9H-嘌呤-9-乙酸 | CAS号141192-83-8 6-(2-trimethyls... | CAS号144364-01-2 9-Allyl-6-chlor... | CAS号149298-99-7 5-(2-amino-6-ox... | CAS号39639-47-9 N-苄基-2-氯-9H-嘌呤-6-胺

鸟嘌呤置于水,Sodium Hydroxide,三氯氧磷体系中,用 1,2-二氯乙烷 用作溶剂,化学反应 15.5H,反应生成2-氨基-6-氯嘌呤
参考文献:轻松合成8-叠氮基-6-苄基氨基嘌呤.
标题:轻松合成8-叠氮基-6-苄基氨基嘌呤.
摘要:在acona存在下,在acoh中用br 2将6-苄氨基嘌呤(1)溴化,以59%的收率获得6-苄氨基-8-溴嘌呤(2).通过与nan 3在二甲亚砜中反应,将溴化物2直接转化为8-叠氮基-6-苄氨基嘌呤(3),将溴化物2直接转化,并将其性能与已知化合物2-叠氮基-2-比较,从而确定了溴化位置.6-苄基氨基嘌呤(11).化合物3和11根据活体植物的主要细胞分裂素效应,在特定的生物测试中检查了它们的生物活性.两种合成的化合物均显示出与典型的细胞分裂素6-苄基氨基嘌呤(1)相似的效果.
Doi:10.1080/15257770.2011.602655

专利信息

专利号:EP-1085020-B1
优先权日:1999-09-17
标题 :Synthesis of peptide nucleic acids
发明人：BATZ HANS-GEORG; HANSEN HENRIK FRYDENLUND; OERUM HENRIK; KOCH TROELS; KOFOED THOMAS
权利人:PNA DIAGNOSTICS APS APPLIED BI
摘要:Protected diaminopurines can be used in the synthesis of nucleic acid binding compounds containing diaminepurine in place of other nucleobases. A method for the synthesis of protected diaminopurines is disclosed which is convenient for incorporating modified diaminopurines into monomers or into oligomers for the preparation of nucleic acid binding compounds.

专利号:US-6998484-B2
优先权日:2000-10-04
标 题:Synthesis of purine locked nucleic acid analogues
发明人：KOCH TROELS; JENSEN FLEMMING REISSIG
权利人:SANTARIS PHARMA AS
摘要:The present invention relates to a new method for the synthesis of purine LNA (Locked Nucleic Acid) analogues which provides a higher overall yield. The method comprising a regioselective 9-N purine glycosylation reaction followed by a one-pot nucleophilic aromatic substitution reaction of the 6-substituent in the purine ring and simultaneous nucleophile-induced intramolecular ring closure of the C-branched carbohydrate to form novel purine LNA analogues. The novel strategy is illustrated by the synthesis of the novel compound (1S,3R,4R,7S)-7-benzyloxy-1-methanesulfonylmethyl-3-(guanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane which is easily converted into (1S,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-3-((2-N-isobutyrylguanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane after isobutyryl protection of the 2-amino purine group and subsequent substitution of 1-methanesulfonyl with benzoate, debenzoylation and debenzylation.

专利号:US-11858953-B2
优先权日:2018-04-04
标 题:Compositions and methods for synthesis of phosphorylated molecules
发明人：CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT
权利人:UNIV CALIFORNIA
摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

专利号:US-7122693-B2
优先权日:1988-04-11
标题 :Acetaldehyde acetal compounds, their synthesis, and uses thereof
发明人：BELLEAU EXECUTRIX OF ESTATE PI; DIXIT DILIP M; NGUYEN-BA NGHE
权利人:SHIRE BIOCHEM INC
摘要:The acetaldehyde compounds, 2-thiobenzoylacetaldehyde diethylacetal, 2-benzoyloxyacetaldehyde bis(2-methoxyethyl)acetal, 2-hydroxyacetaldehyde bis( 2-methoxyethyl)acetal, 2-thiobenzoylacetaldehyde bis(2-methoxy-ethyl)acetal, and 2-thioacetaldehyde bis(2-methoxyethyl)acetal, are useful as intermediates in the synthesis of substituted 1,3-oxathiolanes and substituted 1,3-dioxolanes.

专利号:US-7229797-B1
优先权日:1999-08-20
标 题:Enzymatic synthesis of deoxyribonucleosides
发明人：TISCHER WILHELM; IHLENFELDT HANS-GEORG; BARZU OCTAVIAN; SAKAMOTO HIROSHI; PISTOTNIK ELISABETH; MARLIERE PHILIPPE; POCHET SYLVIE
权利人:PASTEUR INSTITUT
摘要:The present invention relates to a method for the in vitro enzymatic synthesis of deoxyribonucleosides and enzymes suitable for this method.

专利号:US-5144034-A
优先权日:1990-04-06
标题 :Process for the synthesis of cyclopentene derivatives of purines
发明人：JOHNSON M ROSS; PEEL MICHAEL R; STERNBACH DANIEL D
权利人:GLAXO INC
摘要:This invention relates to a new process for preparing certain optically active cyclopentene derivatives and novel intermediates used in this process. In particular, the invention concerns the synthesis of the 1'R-cis isomer of carbovir, (1'R-cis)-2-amino-1,9-dihydro-9[4-(hydroxymethyl)-2-cyclopenten-1-yl]-6H-purin-6-one, an antiviral agent.