原甲酸三乙酯置于三氟化硼,Mercury(II) Diacetate,三氯化铁体系中,化学反应生成1,1,3,3-四乙氧基丙烷 参考文献:Preparation Of Malondialdehyde Derivatives 标题:Preparation Of Malondialdehyde Derivatives
专利号:US-2010099894-A1 优先权日:2006-10-09 标 题 :Method for the Synthesis of Cyclic Acetals by the Reactive Extraction of a Polyol in a Concentrated Solution 发明人:DUBOIS JEAN-LUC; IBORRA CHORNET SARA; VELTY ALEXANDRA I LUCIENNE; CORMA CANOS AVELINO 权利人:DUBOIS JEAN-LUC; IBORRA CHORNET SARA; VELTY ALEXANDRA I LUCIENNE; CORMA CANOS AVELINO 摘要:A method for the synthesis of cyclic acetals comprises reacting at least one carbonyl-function compound selected from aldehydes, ketones, and/or linear acetals, on a polyol in a concentrated aqueous solution exceeding 20 wt % in a reactor containing an acidic catalyst. The carbonyl-function compound is selected so that the cyclic acetal obtained has a water solubility lower than 20000 mg/kg. During the catalytic reaction for the cyclic acetal synthesis, at least one portion of the organic phase containing the cyclic acetal is separated. The acidic catalysis is either homogeneous when using a water-soluble strong acid, or heterogeneous when using a solid acid such as a resin, a zeolite, or any appropriately acidified solid. The extractive reaction method can be used for obtaining high conversions and selectivity.
专利号:US-4266058-A 优先权日:1979-07-04 标 题:Synthesis of 2-isopropylamino-pyrimidine 发明人:DEMOSTHENE CLAUDE G; ASPISI CHRISTIAN R 权利人:SOC D ETUDES PROD CHIMIQUE 摘要:The present invention provides a process for the synthesis of 2-isopropylamino-pyrimidine by aminolysis of 2-methylsulphonyl-pyrimidine using isopropylamine. The aminolysis is effected, according to the present invention, by refluxing isopropylamine and 2-methylsulphonyl-pyrimidine in the absence of a solvent. Using this technique, the 2-isopropylamino-pyrimidine has been obtained in a substantially quantitative yield.
专利号:US-9127123-B2 优先权日:2010-05-27 标 题:Membrane enhanced polymer synthesis 发明人:LIVINGSTON ANDREW GUY; GAFFNEY PIERS ROBERT JAMES; VASCONCELOS RENATO CAMPOS 权利人:LIVINGSTON ANDREW GUY; GAFFNEY PIERS ROBERT JAMES; VASCONCELOS RENATO CAMPOS; IMP INNOVATIONS LTD 摘要:This invention relates to the synthesis of polymers. More specifically, the present invention relates to the synthesis of heterobifunctional polymers and polymers with narrow and mono-disperse molecular weight distributions, and especially to the application of membranes to the synthesis of these polymers.
专利号:US-2006183948-A1 优先权日:2003-03-26 标 题:Process for producing tetraalkoxypropane and derivative thereof 发明人:MITA SHINYA; KAKINUMA SHINICHI; MUROTANI MASAHIRO 权利人:MITA SHINYA; KAKINUMA SHINICHI; MUROTANI MASAHIRO 摘要:In view of the fact that a methyl vinyl ether, which is useful as a starting material for the synthesis of tetraalkoxypropane useful as a skeleton-forming agent having a high reactivity usable as a starting material, etc. for a pharmaceutical and agrochemical intermediates such as a pyrazole derivative or pyrimidine derivative, particularly 1,1,3,3-tetramethoxypropane, is in a gaseous state and difficult to use for industrial production, tetraalkoxypropane useful as a skeleton-forming agent for a pharmaceutical and agrochemical intermediate such as a pyrazole derivative or pyrimidine derivative is easily produced on an industrial scale by using the industrially useable propoxyvinyl ether, as a starting material, without using a gaseous state methyl vinyl ether.
专利号:US-2025136617-A1 优先权日:2022-02-07 标 题:Small molecules cxcr4 agonists, method of synthesis, and method of use 发明人:LIECHTY KENNETH; MALANY SIOBHAN; PEDDIBHOTLA SATYAMAHESHWAR; ZGHEIB CARLOS 权利人:UNIV COLORADO REGENTS; UNIV FLORIDA 摘要:Small molecule CXC chemokine receptor type 4 (CXCR4) agonists are disclosed, methods of their manufacture, and uses thereof, in particular to improve healing and reduce the risk of injury for wound healing in diabetes.
专利号:EP-2076505-A1 优先权日:2006-10-09 标 题 :Method for the synthesis of cyclic acetals by the reactive extraction of a polyol in a concentrated solution
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合成参考文献
参考文献:10.1371/journal.pone.0022221 摘要:Losdat S, Richner H, Blount JD, Helfenstein F. Immune Activation Reduces Sperm Quality in the Great Tit. PLoS ONE. 2011 Jul 12;6(7):e22221. doi: 10.1371/journal.pone.0022221.