CAS: 14320-38-8; Cyclopent-3-Enol

该化合物是一种含有分子式C5H8O的环状不饱和酒精,由五人环组成,在1号位置有一个氢氧基组,3号位置和4号位置之间有双重联系.这一结构在有机合成中赋予了反活性作用,特别是作为制药,农用化学品和特殊化学品的一个构件.它的不饱和环系系统允许通过电益添加或氧化实现功能化,而氢氧基组则能够进一步衍生.化合物的中度极性和挥发性使其适合需要受控再活动的应用.适当的处理由于其易燃性和在某些条件下对聚合性的潜在敏感性,是必不可少的.

结构式图片

相似化合物

37005-79-1 3212-60-0 29783-26-4

欧盟法规

ECHA物质C&L通报

上下游产品

3-Cyclopentenon cyclopenta-1,3-diene cyclopent-3-enyl bromide 2-Cyclobutenyl-methyltosylat2-Cyclobutenyl-methyltosylat (1R,3r,5S)-bicyclo[3.1.0]hexan-3-ol (3-cyclopenten-1-yl)amine [(cyclopent-3-en-1-yloxy)methyl]benzene 4-Cyclopentenyl Brosylate

合成工艺路线路线简述

    6-噁双环[3.1.0]-3-己烯置于lithium Aluminium Tetrahydride体系中,用 乙醚 用作溶剂,以98%的收率获得3-环戊烯-1-醇
    参考文献:A Concise Synthesis Of (−)-Centrolobine Via A Diastereoselective Ring Rearrangement Metathesis-isomerisation Sequence
    标题:A Concise Synthesis Of (−)-Centrolobine Via A Diastereoselective Ring Rearrangement Metathesis-isomerisation Sequence
    摘要:描述了基于非对映选择性环重排复分解-双键异构化序列和一锅交叉复分解-氢化程序的(α)-Centrolobine (1) 的全合成.
    Doi:10.1039/b602056A

    海关参考信息

    专利信息


    专利号:US-11629163-B2
    优先权日:2017-06-30
    标题:Methods of synthesizing nicotinamide riboside
    发明人:MARCOTULLI ERIC; ALMINANA DAN; DELLINGER RYAN; MORRIS MARK; THAMATAM RAJESH
    权利人:ELYSIUM HEALTH INC
    摘要:Provided herein are efficient and scalable methods for the synthesis of nicotinamide riboside from riboside triacetate. Also provided are compositions comprising nicotinamide riboside, and therapeutic methods employing nicotinamide riboside.

    专利号:US-7612106-B2
    优先权日:2004-12-23
    标题 :Fused pyrazole derivatives and methods of treatment of metabolic-related disorders thereof
    发明人:BOATMAN P DOUGLAS; SCHRADER THOMAS O; SEMPLE GRAEME; SKINNER PHILIP J; JUNG JAE-KYU
    权利人:ARENA PHARM INC
    摘要:The present invention relates to certain fused pyrazole derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. n nAlso provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers, DP receptor antagonists, and the like.

    专利号:US-2018273571-A1
    优先权日:2015-01-08
    标 题 :Concise synthesis of urea derivatives of amphotericin b

    专利号:US-4203901-A
    优先权日:1978-08-21
    标题 :Process for making N-(N'-methylenepyrrolidonyl)-2-substituted anilines
    发明人:GRAHAM DAVID E; SCHNEIDER LOUIS
    权利人:GAF CORP
    摘要:This invention relates to a process for making N-(N'-methylenepyrrolidonyl)-2-substituted anilines in high yield. The products are useful intermediates in the synthesis of herbicides. n The process comprises reacting substantially equivalent molar concentrations of a 2-substituted aniline, as defined herein, with N-methylolpyrrolidone in an aromatic hydrocarbon solvent in the absence of an acid or base catalyst at a reflux temperature of 80°-140° C. while simultaneously and continuously distilling out from the reaction mixture an azeotrope consisting essentially of water and solvent until substantially all the water produced during the reaction has been removed thereby, and, thereafter, crystallizing the product from the remaining solution.

    专利号:EP-0419988-A1
    优先权日:1989-09-25
    标题:Enzymatic enantioselective synthesis of S(-) and R(+) esters of 4-hydroxy-1-cyclopentenone and its 2',2'-dimethyl-1',3'-propandiol ketal

    专利号:US-4216152-A
    优先权日:1978-12-14
    标 题:Process for making N-(N'-methylenepyrrolidonyl)-2-substituted anilines
    发明人:GRAHAM DAVID E; SCHNEIDER LOUIS
    权利人:GAF CORP
    摘要:This invention relates to an improved process for making N-(N'-methylenepyrrolidonyl)-2-substituted anilines which are useful intermediates in the synthesis of agricultural herbicides. n This process of the invention comprises reacting a 2-substituted aniline with N-chloromethylpyrrolidone at about room temperature in the presence of an acid acceptor. Such room temperature alkylation of the aniline prevents excessive side reactions, particularly with a substituent in the 2-position of the aniline, such as an alkenyl group, which is sensitive to alkylating agents which require excessive heating to effective the condensation reaction.
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    合成参考文献


    摘要:Block, E., Science of Synthesis, (2008) 39, 670.
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