CAS: 148-79-8; Thiabendazole

相似化合物

26097-80-3 877928-42-2 142383-75-3

上下游产品

CAS号1452-15-9 4-氰基噻唑 | CAS号95-54-5 邻苯二胺(OPD) | CAS号50-81-7 抗坏血酸 | CAS号71-36-3 正丁醇 | CAS号39145-59-0 benzene-o-diami... | CAS号3364-80-5 噻唑-4-甲醛 | CAS号5329-14-6 氨基磺酸 | CAS号13195-64-7 丙二酸二异丙酯 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号2859-58-7 1,2-dihydroisoq... | CAS号51-17-2 苯并咪唑 | CAS号5805-52-7 1H-苯并咪唑-2-甲酰胺 | CAS号939-70-8 2-乙酰苯并咪唑 | CAS号1865-09-4 1H-苯并咪唑-2-羧酸乙酯 | CAS号948-71-0 5-羟基噻苯咪唑 | CAS号92-83-1 氧杂蒽 | CAS号3575-05-1 5-硝基-2-(1,3-噻唑-... | CAS号33705-43-0 4-(1-benzylbenz... | CAS号32594-70-0 N-METHYLTHIABEN... | CAS号945-65-3 1H-Benzimidazol...

4-(N-苯基脒基)噻唑盐酸盐置于sodium Carbonate,Sodium Hypochlorite体系中,用 甲醇,水 用作溶剂,化学反应 2.33H,反应生成噻菌灵
参考文献:Naocl介导的通过分子内胺化反应制备噻菌灵的实用方法
标题:Naocl介导的通过分子内胺化反应制备噻菌灵的实用方法
摘要:从易于获得的苯胺和4-氰基噻唑合成了一系列新型的氯化噻苯达唑(6A-M),产率中等至非常好.使用1 H NMR,13 C NMR,Ir和质谱对所有合成的化合物进行全面表征.另外,化合物(6F)的结构通过单晶x射线衍射确认.另外,使用我们优化的条件对2-取代的苯并咪唑和2-苯基苯并噻唑的合成进行了研究,结果在本文中给出.
Doi:10.1016/j.Tetlet.2017.07.086

专利信息

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-2008146656-A1
优先权日:2005-06-01
标题:Use of a steroid sulphatase inhibitor for inhibiting the synthesis of androstenedione and/or testosterone
发明人：REED MICHAEL JOHN; PUROHIT ATUL; WOO LOK WAI LAWRENCE; POTTER BARRY VICTOR LLOYD
权利人:REED MICHAEL JOHN; PUROHIT ATUL; WOO LOK WAI LAWRENCE; POTTER BARRY VICTOR LLOYD
摘要:There is provided use of a compound capable of inhibiting a steroid sulphatase enzyme (E.C.3.1.6.2) in the manufacture of a medicament for inhibiting in vivo synthesis of at least one of androstenedione and testosterone, which may be useful for the treatment of hirsutism, excess sebum production, benign breast disease, benign ovarian disease, polycystic ovarian disease and female infertility among others.

专利号:EP-1590332-B1
优先权日:2003-01-09
标题:A process for the synthesis of bisbenzimidazoles and their derivatives.
发明人：JAIN AKASH; TAWAR URMILA; CHANDRA RAMESH; DWARAKANATH B S; CHAUDHURY N K; TANDON VIBHA
权利人:UNIV DELHI
摘要:A process for the synthesis of bisbenzimidazoles and its derivations comprising; (i) reacting 5 chloroaniline with zinc dust and acetic anhydride to produce 5 chloroacetanilide; (ii) reacting 5 chloroacetanilide with HN03 to produce 2-nitro-5-chloroacetanilide; (ix) adding sodium methoxide to 2-nitro-5-ch1oroaniline; (x) heating 2-nitro-5-chloroaniline, methyl piperazine, anhydrous K2CO3 and Dimethyl formamide at 100-120°C produce a mixture which is cooled by pouring ice and is filtered to obtain 5-(4'-methylpiperazin-1'-yl)-2-nitroaniline; (xi) treating 5-(4'-methylpiperazin-l'yl)-2-nitroaniline with Pd/C to produce 2-amino-4-(4'-methylpiperazin-1'-yl) aniline; (xii) refluxing a mixture of 2-amino-4-(4'-methylpiperazin-1'yl) aniline and ethyl-4-amino-3-nitrobenzenecarboximidate hydrochloride in presence of ethanol/glacial acetic acid to produce 4-[5'-(4'-methylpiperazin-1'-yl) 15 benzimidazol-2'-yl)-2-nitroaniline; (xiii) treating a solution of 4-[5'-(4'-methylpiperazin-1'-yi) benzimidazol-2'-yl)-2-nitroaniline with palladium on carbon to yield 2-amino-4-[5'-(4'-Methylpiperazin-1'-yl)benzimidazol-2'-yl]aniline; (xiv) heating 2-amino-4-[5'-(4'-Methylpiperazin-1'-yl)benzimidazol-2'-yl]aniline and 3-4-dimethoxy benzaldehyde using nitrobenzene as a solvent at 110-150°C to produce (DMA) i.e 5-(4-methylpiperazin-1-yl)-2-[2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl] benzimidazole; (ix) heating 2-amino-4-[5'-(4'-Methylpiperazin-1'-yl) benzimidazol-2'-YI] aniline and 5-Formyl-[3-methoxy-4-hydroxy benzimidazole] using nitrobenzene at 110°C to 150°C in presence of argon to produce (TBZ) i.e 5-(4-methylpiperazine-1-yl)-2-[2' (2'-(4-hydroxy-3methoxyphenyl)5'benzimidazolyl) -5'- benzimidazolyl] benzimidazole.

专利号:US-10730752-B2
优先权日:2016-05-03
标题:Heteroatom-doped porous carbons for clean energy applications and methods for their synthesis
发明人：EL-KADERI HANI M; ASHOURIRAD BABAK
权利人:UNIV VIRGINIA COMMONWEALTH
摘要:Methods for a facile, template free and one-step synthesis of nanoporous carbons by using a heterocyclic aromatic organic compound as a single source precursor of both carbon and nitrogen are described. The heterocyclic aromatic organic compound contains nitrogen in pyrrolic and/or pyridinic positions and is chemically activated with NaOH, KOH or ZnCl2 at high temperatures in a solid state mixture as a synthesis protocol to promote fine micropores during carbonization. Nanoporous carbons synthesized by these methods that have superior gas sorption/storage and energy storage properties are also described. The nanoporous carbons are useful as carbon sequestration agents and supercapacitors.

专利号:US-2024239791-A1
优先权日:2021-04-26
标题 :Processes for the synthesis of valbenazine
发明人：TUCKER JOHN LLOYD
权利人:NEUROCRINE BIOSCIENCES INC
摘要:The present application relates to processes for preparing (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate), which is an inhibitor of vesicular monoamine transporter 2 (VMAT2) useful in the treatment of hyperkinetic movement disorders such as tardive dyskinesia (TD).

专利号:WO-2024129887-A1
优先权日:2022-12-13
标题:Biobased synthesis of glucodiamine
发明人：MILLET AGUSTIN; WOELK HANS-JOERG; LEE TONI M; CHAKRABARTI GAURAB; HUNT SEAN
权利人:SOLUGEN INC
摘要:A method of preparing glucodiamine, comprising contacting glucose with an enzyme oxidation catalyst under conditions suitable for the formation of glucodialdose; contacting glucodialdose with a nitrogen-containing compound under conditions suitable for the formation of glucodioxime; and reducing glucodioxime under conditions suitable for the formation of glucodiamine. A method of preparing glucodiamine, comprising contacting glucodioxime with a dehydration catalyst under conditions suitable for the formation of glucodinitrile; and reducing glucodinitrile under conditions suitable for the formation of glucodiamine. A chemoenzymatic method of producing a bio-based amide platform chemical, comprising: contacting glucose with a biocatalyst under conditions suitable for the formation of glucodialdose; contacting glucodialdose with a base under conditions suitable for the formation of glucodioxime; and contacting glucodioxime with a hydrogenation catalyst in the presence of hydrogen under conditions suitable for formation of glucodiamine.