CAS: 165668-41-7; N-(3-Chloro-1H-Indol-7-yl)Benzene-1,4-Disulfonamide

上下游产品

N-(1H-Indole-7-yl)-4-Sulfamoylbenzenesulfonamide 165669-28-3
7-氨基-3-氯吲哚 3-Chloro-1H-Indol-7-Amine 165669-13-6
3-氯-7-硝基吲哚 3-Chloro-7-Nitroindole 165669-14-7

N-(1H-Indole-7-yl)-4-Sulfamoylbenzenesulfonamide置于n-氯代丁二酰亚胺体系中,用 二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 1.0H,反应生成2-[n-(2-氰乙基)-4-[(2,6-二氯-4-硝基苯基)偶氮]苯胺基]乙酸乙酯
参考文献:Ep1813602
标题:Ep1813602

专利信息

专利号:US-7935704-B2
优先权日:2003-08-01
标 题 :Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
发明人：PALLADINO MICHAEL A; LLOYD GEORGE KENNETH; HAYASHI YOSHIO; NICHOLSON BENJAMIN
权利人:NEREUS PHARMACEUTICALS INC
摘要:Compounds represented by the following structure (I) are disclosed: n nas are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R 1 , R 1 ′, R 1 ″, R 2 , R 3 , R 4 , R 5 , and R 6 , X 1 and X 2 , Y, Z, Z 1 , Z 2 , Z 3 , and Z 4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating vascular proliferation are also disclosed.

专利号:US-7956058-B2
优先权日:2002-08-02
标 题:Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
发明人：HAYASHI YOSHIO; PALLADINO JR MICHAEL A; GRODBERG JENNIFER
权利人:NEREUS PHARMACEUTICALS INC
摘要:Compounds represented by the following structure (I) are disclosed: n nas are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R 1 , R 1 ′, R 1 ′, R 2 , R 3 , R 4 , R 5 , and R 6 , X 1 and X 2 , Y, Z, Z 1 , Z 2 , Z 3 , and Z 4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating cancer and fungal infection are also disclosed.

专利号:EP-2054420-B1
优先权日:2006-08-02
标题:Benzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonamides as inhibitors of carbonic anhydrase and the intermediates for production thereof
发明人：MATULIS DAUMANTAS; DUDUTIENE VIRGINIJA; MATULIENE JURGITA; MISTINAITE LINA
权利人:BIOTECHNOLOGIJOS INST
摘要:The invention is related to novel compounds - benzimidazo[1,2-c][1,2,3]thiadiazole sulfonamides, corresponding to the general formula (I). The compounds can be used in biomedicine as active ingredients in pharmaceutical formulations, because they inhibit enzymes which participate in disease progression such as glaucome. The compounds of formula (I) inhibits enzymes such as carbonic anhydrases and metallo proteinases. This invention is also related to new intermediate compounds which are used for the synthesis of sulfonamides of formula (I).

专利号:US-2023266302-A1
优先权日:2020-07-24
标 题:Synthesis and use of n-benzyl sulfonamides
发明人：LAMAR ANGUS A; SHEAFF ROBERT J
权利人:THE UNIV OF TULSA
摘要:Disclosed is a method for preparing N-benzyl sulfonamides. Also disclosed is a composition for treating cancer. The composition includes a N-benzyl sulfonamide and a metabolic inhibitor. Also disclosed is a method for determining the impact on cell ATP levels of a composition containing a N-benzyl sulfonamide with or without a metabolic inhibitor.

专利号:US-9290529-B2
优先权日:2011-10-24
标题:Carbonic anhydrase inhibitors and method of their production
发明人：BRYNDA JIRI; CIGLER PETR; GRUNER BOHUMIR; MALOY REZACOVA PAVLINA; MADER PAVEL; SICHA VACLAV; BAKARDJIEV MARIO; HOLUB JOSEF; DZUBAK PETR; HAJDUCH MARIAN
权利人:USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CESKE REPUBLIKY V V I; USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY V V I; USTAV ANORGANICKE CHEMIE AKADEMIE VED CESKE REPUBLIKY V V I; UNIV PALACKEHO
摘要:Derivatives of boron cluster compounds of general formula I and their pharmaceutically acceptable salts and solvates, and their specific inhibition effect on the enzyme carbonic anhydrase IX, a protein overexpressed in cancer tissues. Methods of synthesis and the use of the novel derivatives. These inhibitors of human carbonic anhydrase IX can be used as active compounds of pharmaceuticals for diagnostics and/or therapy of cancer diseases.

专利号:US-7674903-B2
优先权日:2002-08-02
标题:Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof