CAS: 18881-17-9; (S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)Methanol

相似化合物

62855-02-1 243858-66-4 103733-65-9

上下游产品

CAS号67123-97-1 1,2,3,4-四氢异喹啉-3-羧酸 | CAS号74163-81-8 (S)-1,2,3,4-四氢异... | CAS号77497-95-1 L-1,2,3,4-四氢异喹啉... | CAS号15912-55-7 1,2,3,4-四氢异喹啉-3-羧酸乙酯 | CAS号63-91-2 L-苯丙氨酸 | CAS号77497-96-2 S-1,2,3,4-四氢异喹啉... | CAS号50-00-0 甲醛 | CAS号145525-27-5 (S)-3-甲酰基-3,4-二... | CAS号444583-19-1 (R)-3-甲酰基-3,4-二...

S-1,2,3,4-四氢异喹啉-3-羧酸苄酯盐酸盐置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 用作溶剂,化学反应生成(S)-(-)-1,2,3,4-四氢-3-异喹啉甲醇
参考文献:芳香酮的对映选择性催化硼烷还原:(S)-卟啉的两种手性β-氨基醇的合成与应用
标题:芳香酮的对映选择性催化硼烷还原:(S)-卟啉的两种手性β-氨基醇的合成与应用
摘要:在原位从两个光学活性的β氨基醇的手性形成恶唑硼烷催化剂(小号)-1和(小号)-2从苄基(小号)-1,2,3,4-四氢异喹啉-3-羧酸乙酯(小号)-3已成功地用于各种芳族酮的对映选择性催化均相硼烷还原.
Doi:10.1016/s0957-4166(00)80196-2

专利信息

专利号:US-7692019-B2
优先权日:2000-12-04
标 题:Methods for the stereoselective synthesis of substituted piperidines
发明人：AQUILA BRIAN M; BANNISTER THOMAS D; CUNY GREGORY D; HAUSKE JAMES R; HEFFERNAN MICHELE L R; HOEMANN MICHAEL Z; KESSLER DONALD W; SHAO LIMING; WU XINHE; XIE ROGER L
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to methods of synthesizing substituted piperidines. A second aspect of the present invention relates to stereoselective methods of synthesizing substituted piperidines. The methods of the present invention will find use in the synthesis of compounds useful for treatment of numerous ailments, conditions and diseases that afflict mammals, including but not limited to addiction and pain. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the substituted piperidines using the methods of the present invention. An additional aspect of the present invention relates to enantiomerically substituted pyrrolidines, piperidines, and azepines.

专利号:CN-117586170-B
优先权日:2024-01-19
标题 :Synthesis method of indole acyl derivative and isoquinoline carboxylic acid derivative