专利号:US-11059835-B2 优先权日:2014-08-15 标 题 :Synthesis of cephalosporin compounds 发明人:WALLER DAVID; GAZDA GREGORY; MINDEN ZACHARY; BARTON LISA; LEIGH CLIFTON 权利人:MERCK SHARP & DOHME 摘要:Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction.
专利号:EP-1071442-B9 优先权日:1998-03-23 标题:Methods and compositions for peptide synthesis (t-20) 发明人:KANG MYUNG-CHOL; BRAY BRIAN; LICHTY MAYNARD; MADER CATHERINE; MERUTKA GENE 权利人:TRIMERIS INC 摘要:The present invention relates, first, to methods for the synthesis of peptides, in particular T-20 (also referred to as 'DP-178'; SEQ ID NO:1) and T-20-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides of interest (e.g., T-20). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full length T-20 and T-20-like peptides.
专利号:US-9783642-B1 优先权日:2016-04-12 标题 :Difunctional polyhedral oligomeric silsesquioxane derivative and synthesis thereof 发明人:LIN YUNG-CHIH; KUO SHIAO-WEI 权利人:NAT SUN YAT-SEN UNIV 摘要:A difunctional polyhedral oligomeric silsesquioxane derivative and synthesis of the present invention is disclosed. The difunctional polyhedral oligomeric silsesquioxane derivative is represented by following formula (I), wherein R is selected from one of n nandn n nThe synthesis of the difunctional polyhedral oligomeric silsesquioxane derivative includes obtaining bis-PA-DDSQ compound though addition reaction of DDSQ compound and 4-acetoxystyrene, obtaining bis-Ph-DDSQ compound though hydrolytic reaction of bis-PA-DDSQ compound and hydrazine, and obtaining bis-AlBz-DDSQ compound though cycloaddition reaction of bis-Ph-DDSQ compound and paraformaldehyde.
专利号:US-7223845-B2 优先权日:1998-06-16 标 题:Synthetic glycosulfopeptides and methods of synthesis thereof 发明人:CUMMINGS RICHARD D; MCEVER RODGER P 权利人:UNIV OKLAHOMA 摘要:A new class of synthetic glycosulfopeptides (GSPs) which have one or more sulfated tyrosine residues and a glycan linked to the peptide, the glycan preferably including a sialyl Lewis x group or a sialyl Lewis a group. In a preferred version the GSPs have an O-glycan comprising a β1,6 linkage to a GalNAc. The present invention further contemplates in vitro methods of the synthesis of these GSPs without the use of the cells and methods of their use in vivo as powerful anti-inflammatory antithrombotic, or anti-metastatic compounds. The invention also contemplates a method of synthesizing oligosaccharides by cleaving the glycan from the GSP.
专利号:US-6593459-B1 优先权日:1998-06-16 标题:Synthetic glycosulfopeptides and methods of synthesis thereof 发明人:CUMMINGS RICHARD D; MCEVER RODGER P 权利人:UNIV OKLAHOMA 摘要:A new class of synthetic glycosulfopeptides (GSPs) which have one or more sulfated tyrosine residues and a glycan linked to the peptide, the glycan preferably including a sialyl Lewis x group or a sialyl Lewis a group. In a preferred version the GSPs have an O-glycan comprising a β1,6 linkage to a GalNAc. The present invention further contemplates in vitro methods of the synthesis of these GSPs without the use of the cells and methods of their use in vivo as powerful anti-inflammatory antithrombotic, or anti-metastatic compounds. The invention also contemplates a method of synthesizing oligosaccharides by cleaving the glycan from the GSP.
专利号:WO-2009046392-A1 优先权日:2007-10-04 标题 :Synthesis of bio-functionalized rare earth doped upconverting nanophosphors 发明人:JU YIGUANG; SHAN JINGNING 权利人:UNIV PRINCETON; JU YIGUANG; SHAN JINGNING 摘要:Methods for preparing rare earth doped monodisperse, hexagonal phase upconverting nanophosphors, the steps of which include: dissolving one or more rare earth precursor compounds and one or more host metal fluoride compounds in a solvent containing a tri-substituted phosphine or a tri-substituted phosphine oxide to form a solution; heating the solution to a temperature above about 250 °C at which the phosphine or phosphine oxide remains liquid and does not decompose; and precipitating and isolating from the solution phosphorescent hexagonal phase monodisperse nanoparticles of the host metal compound doped with one or more rare earth elements. Nanoparticles according to the present invention, and methods for coating rare earth doped upconverting nanophosphors with SiO2 are also disclosed.
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合成参考文献
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