CAS: 33097-13-1; 4,6-Dichloro-2-(Methylthio)Pyrimidine-5-Carbonitrile

相似化合物

33097-11-9 313339-35-4 33089-15-5

上下游产品

4,6-dichloro-2-(methylthio)-5-pyrimidinecarbaldehyde oxime 2,4-dihydroxy-2-methylmercaptopyrimidine (zwitterionic form) 4,6-dichloro-2-methylsulfanylpyrimidine-5-carboxyaldehyde 4-Chloro-6-(2-chloro-phenylamino)-2-methylsulfanyl-pyrimidine-5-carbonitrile 4-(4-Bromo-phenylamino)-6-chloro-2-methylsulfanyl-pyrimidine-5-carbonitrile [6-(4-Bromo-phenylamino)-5-cyano-2-methylsulfanyl-pyrimidin-4-ylsulfanyl]-acetic acid ethyl ester [6-(2-Chloro-phenylamino)-5-cyano-2-methylsulfanyl-pyrimidin-4-ylsulfanyl]-acetic acid ethyl ester

2-(甲硫基)-4,6-二氯-5-嘧啶甲醛置于氯化亚砜,盐酸羟胺,溶剂黄146体系中,用 乙醇 作为反应溶剂,化学反应 5.0H,反应生成 4,6-二氯-5-氰基-2-甲硫基嘧啶
参考文献:Wo2006/104889
标题:Wo2006/104889

专利信息

专利号:US-7579356-B2
优先权日:2005-05-04
标 题:Thia-tetraazaacenaphthylene kinase inhibitors
发明人：BATTISTA KATHLEEN A; BIGNAN GILLES C; CONNOLLY PETER J; HAYDEN STUART; JOHNSON SIGMOND G; LIN RONGHUI; PANDEY NIRANJAN B; POWELL MARK T
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to novel thia-tetraazaacenaphthylene compounds of Formula (I): n nand pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of ATP-protein kinase interactions.