CAS: 374633-33-7; 3-Bromo-2-Hydroxy-6-Picoline

相似化合物

1780045-62-6 54923-31-8 13472-81-6

上下游产品

CAS号500587-45-1 3,5-二溴-2-羟基-6-甲基嘧啶 | CAS号3279-76-3 2-羟基-6-甲基吡啶 | CAS号874493-25-1 3-溴-6-甲基-5-硝基-2...

3,5-二溴-2-羟基-6-甲基嘧啶置于正丁基锂,水体系中,用80%的收率获得3-溴-2-羟基-6-甲基吡啶
参考文献:Efficient Regioselective Preparationof Monobromo And Bromoiodo Hydroxy Pyridines From Dibromoderivativesvia Bromine-Lithium Exchange
标题:Efficient Regioselective Preparationof Monobromo And Bromoiodo Hydroxy Pyridines From Dibromoderivativesvia Bromine-Lithium Exchange
摘要:氢氧嘧啶的环状二溴化反应采用nbs在乙腈中进行,随后与rli进行溴锂交换,最后用h2O或i2捕获,完全区域选择性地得到了单溴和溴碘衍生物.用nis对溴氢氧嘧啶进行碘化反应也是完全区域选择性的.
Doi:10.1055/s-2003-41013

专利信息

专利号:US-4183852-A
优先权日:1977-07-18
标题 :Process for preparing 25-hydroxycholesterol
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:The synthesis of 25-hydroxycholesterol and 25-hydroxycholecalciferol from animal bile starting materials in which hyodeoxycholic acid or an ester thereof is converted to the 3β-hydroxy-5-cholenic acid alkyl ester, and this is converted to 3β-hydroxy-25-cyano-5-cholene by a series of steps by which the sterol nucleus is stabilized by placing a protecting group at the 3 position and then extending the chain from the carbon at the 24 position to a cyanide group at the 25 position. The compound so formed is subjected to a series of reactions by which it is transformed into 25-hydroxy-7-dehydrocholesterol which may then be irradiated with ultraviolet light to 25-hydroxycholecalciferol. The invention discloses new and improved processes for preparing these end products and also new compounds formed as intermediates and processes for preparing these intermediates.

专利号:CA-1150238-A
优先权日:1977-07-18
标 题 :Synthesis of steroids

专利号:GB-1582678-A
优先权日:1977-07-18
标 题 :24 - cyano steroids and their use in the synthesis of 25-hydroxycholesterol

专利号:US-10752654-B2
优先权日:2016-04-04
标 题:Method for preparing a farnesoid X receptor agonist
发明人：RAZZETTI GABRIELE; IULIANO ANNA; GIANNOTTI LUCA; IANNUCCI GRAZIA; ATTOLINO EMANUELE; LUCCHINI VITTORIO; GRAZIOSI RENZO
权利人:DIPHARMA FRANCIS SRL
摘要:The invention relates to a process for preparing a compound of formula (I) n n n n n n n n n n n n in particular obeticholic acid and intermediates suitable for its synthesis.

专利号:CN-115947682-B
优先权日:2023-02-10
标 题 :Synthesis method of 3-bromo-2-hydroxy-6-methylpyridine