CAS: 530-93-8; 2-Tetralone

该化合物是一种属于氯酮类的双环有机化合物,其特点是由环氧环和苯环组成的引信环结构,使其成为四氟磷的衍生物,其特点是位于四氟磷框架第二位置的碳基组(C=O),有助于其反应性和特性.2-Tetronoon一般是一种无色的,有独特味的浅色黄色液体,它溶于乙醇和乙醇等有机溶剂,但在水中溶解程度较低.它适用于有机合成,特别是在生产各种药品和精细化学品方面.该化合物可经受典型的氯酮反应,包括核分裂添加和氧化.此外,它可作为合成更复杂的有机分子的有用中间体.在处理2-Tetroon时,应当采取安全防范措施,因为如果吸入吸入或吸入吸入,可能会对健康造成危害.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号530-91-6 1,2,3,4-四氢萘-2-酚 | CAS号2461-34-9 1A,2,3,7b-四氢-1-... | CAS号447-53-0 1,2-二氢萘 | CAS号135-19-3 2-萘酚 | CAS号1021934-17-7 1-(bromomethyl)... | CAS号61892-23-7 3,4-dihydronaph... | CAS号54509-73-8 ethene | CAS号103-80-0 苯乙酰氯 | CAS号119-64-2 1,2,3,4-四氢萘(THN) | CAS号1194-56-5 1-亚甲基茚烷 | CAS号105983-39-9 1-(3,4-dihydron... | CAS号109104-45-2 1'-Methylspiro[... | CAS号35697-10-0 5-羟基-3,4-二氢-1H-2-萘酮 | CAS号52727-28-3 6-羟基-2-萘满酮 | CAS号53568-05-1 8-羟基-3,4-二氢-1H-2-萘酮 | CAS号37827-68-2 7-羟基-2-萘满酮 | CAS号14442-44-5 ethyl 2-cyano-2... | CAS号1743-01-7 1,2,3,4-四氢萘-2-胺盐酸盐 | CAS号939-26-4 2-(溴甲基)萘 | CAS号4024-14-0 1-甲基-2-四氢萘酮

合成工艺路线路线简述

  • 135-19-3 = 530-93-8 + 530-91-6 + 825-51-4 + 119-64-2
    反应条件:1.1 Reagents: Hydrogen Catalysts: Ruthenium Solvents: Methanol; Rt -> 170 °C; 60 Min,14 Mpa,170 °C
    标题:Hydrogenation Of Hydroxy-Substituted Naphthalenes Using Ru And Ni Catalysts To Desired Decalols And Decalindiols
    作者:Paterova,Iva; Et Al
    参考文献:Reaction Kinetics 日期:2019 卷标:126(2) 页码:829-839
2-萘甲醚置于乙醇,Sodium体系中,化学反应 0.5H,反应生成 β-四氢萘酮
参考文献:Bushby,Richard J.; Patterson,Anne S.,Journal Of Chemical Research,Miniprint,1980,# 9,P. 3801-3852
标题:Bushby,Richard J.; Patterson,Anne S.,Journal Of Chemical Research,Miniprint,1980,# 9,P. 3801-3852

海关参考信息

专利信息


专利号:US-2006167025-A1
优先权日:2004-12-22
标 题:Tricyclic amino alcohols, processes for synthesis of same and use of same as anti-inflammatory drugs
发明人:BERGER MARKUS; SCHMEES NORBERT; SCHAECKE HEIKE; BAURLE STEFAN; REHWINKEL HARTMUT; MENGEL ANNE; KROLIKIEWICZ KONRAD; GROSSBACH DANJA; VOIGTLAENDER DAVID
权利人:BERGER MARKUS; SCHMEES NORBERT; SCHAECKE HEIKE; BAURLE STEFAN; REHWINKEL HARTMUT; MENGEL ANNE; KROLIKIEWICZ KONRAD; GROSSBACH DANJA; VOIGTLAENDER DAVID
摘要:The invention relates to tricyclic amino alcohols of general formula (I) n nmethod for synthesis of same and use of same as anti-inflammatory agents.

专利号:US-4374979-A
优先权日:1981-04-27
标 题:Regiospecific synthesis of anthracyclinone compounds such as daunomycinone
发明人:MITSCHER LESTER A
权利人:UNIV KANSAS ENDOWMENT ASS
摘要:A regiospecific synthesis for anthracyclinones asymmetric is disclosed. The synthesis is based upon a regiospecific bromination of the C-7 position of the alpha -tetralone which after transposing the keto group to the beta -position and reaction with an organo-lithium compound is condensed with a phthalate ester.

专利号:US-7884243-B2
优先权日:2003-12-22
标 题:Process for the synthesis of eneamide derivatives
发明人:BURGOS ALAIN; BERTRAND BLANDINE; ROUSSIASSE SONIA; PLUVIE JEAN-FRANCOIS; BLANCHET SYLVIE; MARTIN JULIETTE; PERRIN FLORENCE; BOURDEAU FRANCOISE
权利人:ZACH SYSTEM
摘要:A process for the production of ene-amide derivatives represented by the formula (I) n nwherein R1 and R2 and R3 are independently a hydrogen atom, an alkyl, a cycloalkyl, a cycloalkylalkyl, an alkylaryl, an aryl, a heterocycle, a cyano, an alkoxy, an aryloxy, a carboxyl, a carbamoyl, —CONR5R6 (in which R5 and R6 are independently an alkyl, arylalkyl or aryl group said ring being substituted or not with a functional group or with R5) or —COOR5 group (in which R5 is an alkyl, alkylaryl or aryl group), said alkyl, cycloalkyl, cycloalkylalkyl, alkylaryl and aryl groups being substituted or not with a functional group or with R5; or R1 and R2 taken together, may form a ring (which terms includes mono-, di- and higher polycyclic ring systems); R4 is a hydrogen atom, an alkyl, an aryl, an alkylaryl, said groups are substituted or not with a halogen atom as Cl, Br, or F; X is an oxygen atom or a leaving group and m is an integer 1 or 2; when m is 1 then X is a leaving group; when m is 2 then X is a oxygen atom, which comprise: a hydrogenation/isomerization reaction in presence of a heterogeneous catalyst, of an oxime derivatives of formula (II)n n nwherein R1, R2 and R3 are as defined above with an acyl derivative of formula (III) (R4CO) m X wherein R4, m and X are as defined above.

专利号:EP-0684234-B1
优先权日:1994-05-26
标 题:Synthesis of benzoquinolinones
发明人:AUDIA JAMES EDMUND; DROSTE JAMES JOSEPH; HEATH PERRY CLARK; WEIGEL LELAND OTTO
权利人:LILLY CO ELI
摘要:A process for preparing 10b-methyl-3-oxo-benzo[f] quinolines of the formula wherein R is hydrogen, methylthio, chloro, bromo or fluoro, and is located at the 7-, 8- or 9-position; comprising reacting a compound of the formula with methyl iodide in an ether solvent to prepare a compound of the formula combining acrylic anhydride or acryloyl chloride with the reaction mixture comprising the compound of formula III to prepare a compound of the formula quenching the reaction with sodium bicarbonate, evaporating the organic solution comprising the compound of formula IV; and combining the residue comprising the compound of formula IV with a trialkylsilane and trifluoroacetic acid in the absence of a solvent to prepare the compound of formula I.

专利号:US-7557237-B2
优先权日:2003-09-09
标题:Process for the synthesis of 3-(3-fluoro-4-hydroxyphenyl)-7-hydroxynaphthonitrile
发明人:WU YANZHONG; REN JIANXIN; GHOSH MOUSUMI; LEVENT MAHMUT; SUTHERLAND KAREN W; RAVEENDRANATH PANOLIL
权利人:WYETH CORP
摘要:A process for making a compound of formula I n nand intermediate compounds thereof, wherein R 1 is CN, F or Cl; R 2 is H or Br; and R 3 and R 4 are each independently H or F. The compounds of formula I are useful in the treatment of chronic inflammatory diseases, such as rheumatoid arthritis.

专利号:US-3697597-A
优先权日:1968-09-21
标 题:Process for the preparation of alpha-oximinoalkyl ketones
发明人:DORLARS ALFONS
权利人:BAYER AG
摘要:Alpha -Oximino ketones, for example, oximinodipropyl ketone, are prepared by reacting a ketone in an inert organic solvent immiscible with water in the presence of a hydrogen halide with an amount of alkyl nitrite that is insufficient for complete nitrosation followed by extracting the ketone formed with an aqueous alkali solution, removing the alkaline extract formed and isolating the Alpha -oximino ketone. The ketones formed are useful as intermediates in the synthesis of pharmaceutical compounds, dyes, analytical reagents, plant protection agents, and optical brighteners.
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✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: Barry M Trost, Et Al. Palladium-Catalyzed Asymmetric Allylic Alkylation Of Alpha-Aryl Ketones. Angew Chem Int Ed Engl. 2002 Sep 16;41(18):3492-5.
[参考文献]: M Goto, Et Al. Rate Enhancement With High Ratio Of The Monoalkylated Product To The Dialkylated Product In The Alkylation Of The Lithium Enolate Of 1-Tetralone With Reactive Alkyl Halides. Chem Pharm Bull (Tokyo). 2000 Oct;48(10):1529-31.
[参考文献]: R D Mattes, Et Al. Ethanol Perception And Ingestion. Physiol Behav. 2001 Jan;72(1-2):217-29.

合成参考文献


摘要:Petasis, N. A., Science of Synthesis, (2010) 47, 183.
摘要:Petasis, N. A., Science of Synthesis, (2010) 47, 236.
摘要:Petasis, N. A., Science of Synthesis, (2010) 47, 238.
摘要:Petasis, N. A., Science of Synthesis, (2010) 47, 168.
摘要:Petasis, N. A., Science of Synthesis, (2010) 47, 224.
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