CAS: 614-16-4; 3-Oxo-3-Phenylpropanenitrile

上下游产品

5-phenylisoxazole sodium ethanolate 5-phenyl-3-isoxazolecarboxylic acid 3-amino-3-phenylacrylonitrile2-benzoyl-3-(2-furyl)prop-2-enenitrile 4-phenyl-5,6,7,8-tetrahydro-quinolin-2-ol 2-acetyl-4-cyano-5-oxo-3,5-diphenyl-valeric acid ethyl ester b]furan-3-carbonitrile4,9-dioxo-2-phenyl-4,9-dihydro-naphtho[2,3-b]furan-3-carbonitrile

苯甲腈置于盐酸,乙醚,乙醇,Sodium Amide体系中,化学反应生成 苯甲酰乙腈
参考文献:Dornow; Kuehlcke; Baxmann,Chemische Berichte,1949,Vol. 82,P. 254,255
标题:Dornow; Kuehlcke; Baxmann,Chemische Berichte,1949,Vol. 82,P. 254,255

专利信息

专利号:US-2005209355-A1
优先权日:2004-03-22
标 题:[Novel Reactions and the Products of Such Reactions]
发明人：ROITMAN LIPA L
权利人:ROITMAN LIPA L
摘要:A process for the synthesis of novel compounds is described comprising reacting tetrachloroethylene with substances containing active methylene group in the presence of free radical initiators. Also, a process for grafting tetrachloroethylene is described comprising reacting these compounds with polymers containing active methylene group in the presence of free radical initiators. Furthermore, a method of conducting such reactions to high conversion is described, comprising conducting the reactions in the reflux condensate. The present invention provides a novel and high yield route for heretofore unobtainable materials.

专利号:US-6107508-A
优先权日:1998-04-03
标 题 :Convergent synthesis of α-aryl-β-ketonitriles
发明人：ZHOU JIACHENG; OH LYNETTE MAY; MA PHILIP
权利人:DU PONT PHARM CO
摘要:The present invention relates to processes for the production of alpha -aryl- beta -ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.

专利号:US-7112679-B2
优先权日:1998-04-03
标题:Convergent synthesis of α-aryl-β-ketonitriles
发明人：ZHOU JIACHENG; OH LYNETTE MAY; MA PHILIP
权利人:BRISTOL MYERS SQUIBB PHARMA CO
摘要:The present invention relates to processes for the production of α-aryl-β-ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.

专利号:US-6025517-A
优先权日:1998-08-03
标题:Fluoxetine process from benzoylacetonitrile
发明人：HILBORN JAMES WALLACE; JURGENS ALEX ROGER
权利人:SEPRACOR INC
摘要:A synthesis of fluoxetine is disclosed. The process begins with benzoylacetonitrile, which is reduced, optionally in the presence of a chiral ligand, to produce the corresponding aminoalcohol, and the amine is carbamoylated without isolation. The alcohol is deprotonated and reacted with 4-chloro- or 4-fluoro benzotrifluoride or with 4-trifluoromethylphenol to provide a carbamate of fluoxetine. The carbamate is reduced with a hydride or with borane to provide fluoxetine free base. The process may be employed for the synthesis of individual enantiomers of fluoxetine.

专利号:US-2023312779-A1
优先权日:2022-03-30
标题:Method for Multicolor Lithography Using Mechanical Force
发明人：ROBB MAXWELL J; OVERHOLTS ANNA
权利人:CALIFORNIA INST OF TECHN
摘要:A macromolecular mechanophore platform that undergoes a mechanically gated chromogenic reaction in the presence of an extrinsic small molecule developing reagent is described, along with methods of synthesis and use thereof in different scenarios. The platform comprises a hetero-Diels Alder adduct embedded into a polymer, wherein the hetero-Diels Alder adduct masks an activated furan, and wherein the activated furan is released from the platform upon application of mechanical force, to react with the developing reagent comprising a secondary amine of choice to produce colored species with photoswitch capabilities. The platform can be used in solution or in solid state, and different colors can be obtained for the same platform, since the color of the generated product is determined by the choice of the developing reagent. Incorporating the platform into polymeric materials enables multicolor mechanical lithography by sequential application of mechanical force and different developing reagents.

专利号:US-2004171829-A1
优先权日:1998-04-03
标 题:Convergent synthesis of alpha-aryl-beta-ketonitriles