CAS: 827-43-0; 4-Methyl-2-Phenyl-1H-Imidazole

该化合物是一种有机化合物,其特点是其一环,即五人组成的含有两个氮原子的环环,其特点是一个苯基组和一个附于该环的甲基组,其化学特性是独特的.该化合物一般是白色至浅黄色晶状固体,因其在各种化学反应中起到催化剂的作用而闻名,特别是在聚合化学领域和作为环氧树脂中的一种固化剂的作用.该苯基组的存在增强了其在有机溶剂中的稳定性和溶解性,而该甲基组则能够影响其再活性.2-苯基-4-甲基氨氨酸酯具有中度毒性,应当按照适当的安全协议加以谨慎处理.该化合物的应用范围扩大到制药和材料科学,在其中它作为更复杂的分子的建筑块.

英文名称4-Methyl-2-Phenyl-1H-Imidazole
中文名称4-甲基-2-苯基咪唑
IUPAC名称4-methyl-2-phenyl-1H-imidazole
其它别名2-苯基-4-甲基咪唑; 5-Methyl-2-Phenyl-1H-Imidazole
CAS编号827-43-0
MFCD编号:MFCD00047015
EINECS号:212-571-5
分子式:C10H10N2
分子量:158.2
产品CID: 1817554
产品分类有机原料→分子砌块→芳杂环类化合物→咪唑类化合物

相似结构搜索
产品信息参考;
InChIKey: TYOXIFXYEIILLY-UHFFFAOYSA-N
InChI=1S/C10H10N2/c1-8-7-11-10(12-8)9-5-3-2-4-6-9/h2-7H,1H3,(H,11,12)…
计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数1.0

相似化合物

68282-47-3 172980-19-7 35345-09-6

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
严重眼刺激类别2A
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
UN编号NONH for all modes of transport
危险品标志Xi
安全声明26-37/39
危险类别码36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

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合成工艺路线路线简述

98-80-6 + 909086-61-9 = 827-43-0
反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Tetrabutylammonium Bromide,(Sp-4-3)-Methyl[4-[[3-(Triethoxysilyl)Propyl]Imino-Kn]-2-Pentanonato-Ko](Triphen... (Sio2 Supported) Solvents: Water; 8 H,60 °C; 60 °C -> Rt
标题:Highly Active And Recyclable Silica Gel-Supported Palladium Catalyst For Mild Cross-Coupling Reactions Of Unactivated Heteroaryl Chlorides
作者:Lee,Dong-Hwan; Et Al
参考文献:Green Chemistry 日期:2010 卷标:12(11) 页码:2024-2029]

1464-98-8 = 827-43-0
反应条件:1.1 Reagents: Ammonia Catalysts: Zinc Triflate Solvents: Toluene; 24 H,150 °C
标题:A Novel Zn-Catalyzed Hydroamination Of Propargylamides: A General Synthesis Of Di- And Tri-Substituted Imidazoles
作者:Pews-Davtyan,Anahit; Et Al
参考文献:Chemical Communications (Cambridge 日期:2011 卷标:47(7) 页码:2152-2154]

159715-63-6 = 827-43-0
反应条件:1.1 Reagents: Cesium Carbonate Solvents: Dimethyl Sulfoxide; 2 H,100 °C
标题:Base-Promoted Cycloisomerization For The Synthesis Of Oxazoles And Imidazoles
作者:Zhang,Lidan; Et Al
参考文献:European Journal Of Organic Chemistry 日期:2018 卷标:2018(48) 页码:6913-6918]

57767-07-4 + 671-59-0 = 827-43-0 [标题:Reaction Conditions
标题:Synthesis Of Imidazole Derivatives From α-Halooximes And Amidines By Use Of Iron Carbonyls
作者:Nakanishi,Saburo; Et Al
参考文献:Chemistry Letters 日期:1983 卷标:(3) 页码:341-2]

5333-86-8 + 7737-16-8 = 827-43-0 [标题:Reaction Conditions
标题:Imidazole Syntheses. Part 7. Imidazoles From Imino Esters,α-Amino Or α-Acylamino Ketones And Liquid Ammonia
作者:Wegner,Kurt; Et Al
参考文献:Archiv Der Pharmazie (Weinheim 日期:1976 卷标:309(5) 页码:391-5]

2450-71-7 = 827-43-0
反应条件:1.1 Catalysts: [(7,8,9,10,11-η)-7-[(Dimethylamino)Methyl]-1,2,3,4,5,6,9,10,11-Nonahydro-8-(Hydr... Solvents: Toluene; 60 H,115 °C
标题:Atom-Economical Synthesis Of N-Heterocycles Via Cascade Inter-/intramolecular C-N Bond-Forming Reactions Catalyzed By Ti Amides
作者:Shen,Hao; Et Al
参考文献:Journal Of The American Chemical Society 日期:2010 卷标:132(33) 页码:11473-11480]

88346-57-0 = 827-43-0
反应条件:1.1 Reagents: Sulfuric Acid Solvents: Ethanol
标题:Thermolysis Of 4-Azidopyrimidines And 4-Azidoquinazolines
作者:Giammanco,Lorenzo; Et Al
参考文献:Heterocycles 日期:1985 卷标:23(6) 页码:1459-64]

2450-71-7 + 5333-86-8 = 827-43-0
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dichloromethane; 40 Min,Rt1.2 6 H,Rt2.1 Reagents: Cesium Carbonate Solvents: Dimethyl Sulfoxide; 2 H,100 °C
标题:Base-Promoted Cycloisomerization For The Synthesis Of Oxazoles And Imidazoles
作者:Zhang,Lidan; Et Al
参考文献:European Journal Of Organic Chemistry 日期:2018 卷标:2018(48) 页码:6913-6918]

= 827-43-0
反应条件:1.1 Reagents: Benzenesulfonic Acid,3-(Diphenylphosphino)-,Sodium Salt (1:1) Catalysts: (η5-2,4-Cyclopentadien-1-Yl)(η3-2-Propen-1-Yl)Palladium Solvents: 1,4-Dioxane; 24 H,80 °C
标题:Synthesis Of Imidazoles And Pyrimidines Using Palladium-Catalyzed Decarboxylative Intramolecular Condensation Of 1,2,4-Oxadiazol-5(4H)-Ones
作者:Shimbayashi,Takuya; Et Al
参考文献:Synlett 日期:2014 卷标:25(13) 页码:1916-1920]

98-80-6 + 909086-61-9 = 827-43-0
反应条件:1.1 Reagents: Potassium Carbonate Catalysts: (Sp-4-3)-Methyl[4-[[3-(Triethoxysilyl)Propyl]Imino-Kn]-2-Pentanonato-Ko](Triphen... (Mesoporous Lta Zeolite-Supported) Solvents: Ethanol,Water; Rt; 5 H,50 °C
标题:Expanded Heterogeneous Suzuki-Miyaura Coupling Reactions Of Aryl And Heteroaryl Chlorides Under Mild Conditions
作者:Lee,Dong-Hwan; Et Al
参考文献:Advanced Synthesis & Catalysis 日期:2009 卷标:351(17) 页码:2912-2920]

1670-14-0 = 827-43-0
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Tetrahydrofuran,Water; Rt -> Reflux1.2 Solvents: Tetrahydrofuran; 30 Min,Reflux; 18 - 20 H,Reflux
标题:Preparation Of 2,4-Disubstituted Imidazoles: 4-(4-Methoxyphenyl)-2-Phenyl-1H-Imidazole
作者:Li,Bryan; Et Al
参考文献:Organic Syntheses 日期:2005 卷标:81 页码:105-111]

618-39-3 = 827-43-0
反应条件:1.1 Reagents: Potassium Bicarbonate Solvents: Tetrahydrofuran,Water
标题:An Optimized Process For Formation Of 2,4-Disubstituted Imidazoles From Condensation Of Amidines And α-Haloketones
作者:Li,Bryan; Et Al
参考文献:Organic Process Research & Development 日期:2002 卷标:6(5) 页码:682-683]

18735-74-5 = 827-43-0
反应条件:1.1 Reagents: Ammonium Hydroxide
标题:Further Studies Of Oxazoles And Glyoxalines
作者:Cornforth,J. W.; Et Al
参考文献:Journal Of The Chemical Society 日期:1948 卷标:1960 页码:1960-4]

613-92-3 + 6224-91-5 = 827-43-0
反应条件:1.1 Reagents: Cesium Carbonate Solvents: Dimethyl Sulfoxide; 24 H,100 °C
标题:Base-Promoted Annulation Of Amidoximes With Alkynes: Simple Access To 2,4-Disubstituted Imidazoles
作者:Mehmood,Hina; Et Al
参考文献:Molecules 日期:2020 卷标:25(16)]

= 827-43-0 [标题:Reaction Conditions
标题:Synthesis Of Imidazoles From Alkenes
作者:Casey,Michael; Et Al
参考文献:Journal Of The Chemical Society 日期:1984 卷标:(8) 页码:1933-41]

618-39-3 = 827-43-0
反应条件:1.1 Reagents: Methanesulfonic Acid,Methylazanyl 4-Methylbenzenesulfonate Solvents: Toluene,Tetrahydrofuran; 15 H,40 °C; 40 °C -> Rt1.2 Reagents: Potassium Hydroxide Solvents: Toluene,Tetrahydrofuran; 18 H,Reflux
标题:Direct α-Oxytosylation Of Carbonyl Compounds: One-Pot Synthesis Of Heterocycles
作者:John,Oliver R. S.; Et Al
参考文献:Organic Letters 日期:2007 卷标:9(20) 页码:4009-4012]

= 827-43-0 [标题:Reaction Conditions
标题:Product Class 3: Imidazoles
作者:Grimmett,M. R.
参考文献:Science Of Synthesis 日期:2002 卷标:12 页码:325-528]

80919-37-5 = 827-43-0 [标题:Reaction Conditions
标题:Iodocyclizations Of Allylamidines And -Ureas
作者:Hunt,Peter A.; Et Al
参考文献:Tetrahedron Letters 日期:1988 卷标:29(24) 页码:3001-2]

1456-22-0 = 827-43-0
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; 12 H,50 °C1.2 Reagents: Water2.1 Reagents: Benzenesulfonic Acid,3-(Diphenylphosphino)-,Sodium Salt (1:1) Catalysts: (η5-2,4-Cyclopentadien-1-Yl)(η3-2-Propen-1-Yl)Palladium Solvents: 1,4-Dioxane; 24 H,80 °C
标题:Synthesis Of Imidazoles And Pyrimidines Using Palladium-Catalyzed Decarboxylative Intramolecular Condensation Of 1,2,4-Oxadiazol-5(4H)-Ones
作者:Shimbayashi,Takuya; Et Al
参考文献:Synlett 日期:2014 卷标:25(13) 页码:1916-1920

苯甲亚胺酸乙酯盐酸盐置于potassium Carbonate,Caesium Carbonate体系中,用二氯甲烷,二甲基亚砜作为反应溶剂,化学反应 8.67H,反应生成 4-甲基-2-苯基咪唑
参考文献:碱促进的环异构化反应合成恶唑和咪唑
标题:碱促进的环异构化反应合成恶唑和咪唑
摘要:已经开发出了一种碳酸铯促进的,过渡金属和无卤素的5 Exo-Dig型环化反应,用于合成恶唑和咪唑.
DOI:10.1002/ejoc.201801351

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2902200000-苯
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专利信息

专利号:WO-2006066260-A9
优先权日:2004-12-17
标题 :Compositions of and methods for producing phosphorus-chiral monomers and oligomers
发明人：SZABO TOMAS; STAWINSKI JACEK
权利人:THIOSENSE INC; SZABO TOMAS; STAWINSKI JACEK
摘要:Described herein are phosphorus-containing monomers and oligomers and methods for making such monomers and oligomers. Each subunit of the oligomers may be the same or different. Furthermore, the phosphorus atom in the monomers and at least two of the phosphorus atoms in the oligomers are chiral, that is, attached to four different chemical groups in a desired configuration. The methods described herein, which use an intramolecular catalyst, permit the synthesis of oligomers in which each chiral phosphorus center is in a desired stereochemical configuration.

专利号:US-4658009-A
优先权日:1985-03-14
标题:Novel 2-substituted-4,6-diamino-s-triazine/isocyanuric acid adduct, process for synthesis of said adduct and process for curing polyepoxy resin with said adduct
发明人：KAMAGATA KAZUO; YAMADA TOSHIAKI; SAWA NATSUO
权利人:SHIKOKU CHEM
摘要:Disclosed is a 2-substituted-4,6-diamino-s-triazine/isocyanuric acid adduct represented by the following formula: (1) wherein R stands for an alkyl group having 2 to 20 carbon atoms, an unsubstituted or cyano group-substituted aryl group, or a group of the formula R1-CH2CH2- in which R1 stands for an alkoxy group having up to 20 carbon atoms, an acyloxy group, an amino group, an N-substituted amino group, a benzotriazolyl group or a 2-alkylimidazolyl-(4)-dithiocarbonyl group, or by the following formula: (2) wherein R2 stands for an alkylene group which may have an intervening imino or phenylene group. When this adduct is used for curing a polyepoxy resin, a cured product having good heat resistance, insulating property and adhesion and an excellent migration-preventing effect is formed.

专利号:US-8043786-B2
优先权日:2003-03-05
标题 :Acid generators, sulfonic acids, sulfonyl halides, and radiation sensitive resin compositions
发明人：EBATA SATOSHI; WANG YONG; NISHIMURA ISAO
权利人:JSR CORP
摘要:The invention provides novel acid generators which are unproblematic in combustibility and accumulation inside the human body and can generate acids having high acidities and high boiling points and exhibiting properly short diffusion lengths in resist coating films and which permit the formation of resist patterns excellent smoothness with little dependence on the denseness of a mask pattern; sulfonic acids generated from the acid generators; sulfonyl halides useful as raw material in the synthesis of the acid generators; and radiation-sensitive resin compositions containing the acid generators. The acid generators have structures represented by the general formula (I), n nwherein R 1 is a monovalent substituent such as alkoxycarbonyl, alkylsulfonyl, or alkoxysulfonyl; R 2 to R 4 are each hydrogen or alkyl; k is an integer of 0 or above; and n is an integer of 0 to 5. Among the radiation-sensitive resin compositions, a positive one contains a resin having acid-dissociable groups in addition to the above acid generator, while a negative one contains an alkali-soluble resin and a crosslinking agent in addition to the acid generator.

专利号:US-8053165-B2
优先权日:2008-03-18
标题:Hydroxyl-containing monomer, polymer, resist composition, and patterning process
发明人：KINSHO TAKESHI; OHASHI MASAKI; HASEGAWA KOJI; WATANABE TAKERU
权利人:SHINETSU CHEMICAL CO
摘要:A hydroxyl-containing monomer of formula (1) is provided wherein R 1 is H, F, methyl or trifluoromethyl, R 2 and R 3 are monovalent C 1 -C 15 hydrocarbon groups, or R 2 and R 3 may form an aliphatic ring. The monomers are useful for the synthesis of polymers which have high transparency to radiation of up to 500 nm and the effect of controlling acid diffusion so that the polymers may be used as a base resin to formulate radiation-sensitive resist compositions having a high resolution.

专利号:KR-20090102733-A
优先权日:2006-12-27
标题 :Method for synthesis of hyperbranched polymer, hyperbranched polymer, resist composition, semiconductor integrated circuit, and method for production of semiconductor integrated circuit

专利号:US-2010121022-A1
优先权日:2006-10-17
标题 :1,3-dipolar cycloaddition of azides to alkynes
发明人：MUSA OSAMA M; SRIDHAR LAXMISHA M; YUAN-HUFFMAN QINGWEN WENDY
权利人:MUSA OSAMA M; SRIDHAR LAXMISHA M; YUAN-HUFFMAN QINGWEN WENDY
摘要:A process for the bulk polymerization, in the absence of any solvent, of a reactant containing azide functionality and a reactant containing a terminal alkyne functionality, in the presence of Cu (I) catalyst or in the presence of a Cu(II) catalyst without a reducing agent, is described. Polymerization can be achieved at temperatures less than 100Â° C., which is suitable for low temperature cures. A controlled synthesis for low molecular weight oligomers is disclosed.

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[参考文献]: Silke B Bodendiek, Et Al. Triarylmethanes, A New Class Of Cx50 Inhibitors. Front Pharmacol. 2012 Jun 6:3:106.

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摘要:Grimmett, M. R., Science of Synthesis, (2002) 12, 449.

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CAS: 827-43-0; 4-Methyl-2-Phenyl-1H-Imidazole

相似化合物

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