CAS: 92-52-4; Biphenyl

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CAS号37729-18-3 2-([1,1'-联苯]-4-基)乙醇 | CAS号111033-77-3 2-(2-phenylphen... | CAS号52709-83-8 4-正-丁基-4-氰基联苯 | CAS号47162-00-5 4-正辛酰联苯 | CAS号527-53-7 1,2,3,5-四甲基苯 | CAS号644-08-6 4-甲基联苯 | CAS号643-58-3 2-苯基甲苯 | CAS号643-93-6 3-甲基联苯 | CAS号5748-42-5 4-(4-叔丁基苯基)苯甲酸 | CAS号3478-90-8 4,4'-二苯基苯甲酮

乙酸苯汞置于di(Rhodium)Tetracarbonyl Dichloride 四丁基碘化铵体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 24.0H,以75%的收率获得产物联苯
参考文献:Reactions Of Organometallic Compounds,Catalyzed By Transition Metal Complexes. 7. Oxidative Demercuration Of Arylmercury In The Presence Of Complexes Of Palladium And Rhodium
标题:Reactions Of Organometallic Compounds,Catalyzed By Transition Metal Complexes. 7. Oxidative Demercuration Of Arylmercury In The Presence Of Complexes Of Palladium And Rhodium
摘要:
DOI:10.1007/bf00948854

专利信息

专利号:US-7479569-B2
优先权日:2004-02-13
标题:Process for the synthesis of (7-methoxy-3,4-dihydro-1-naphthalenyl) acetonitrile and its application in the synthesis of agomelatine
发明人：SOUVIE JEAN-CLAUDE; GONZALEZ BLANCO ISAAC
权利人:SERVIER LAB
摘要:A process for the industrial synthesis of the compound of formula (I) n nApplication in the synthesis of agomelatine.

专利号:WO-9837078-A1
优先权日:1997-02-20
标题 :Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS
摘要:A solid phase method for the synthesis of a plurality of differently substituted thiophenes with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The thiophenes are prepared by reaction of a substrate-bound primary or secondary amine with a thiophosgene equivalent and reaction of the resulting intermediate with an acceptor-substituted acetonitrile in the presence of a base. Alkylation with an appropriate alkyl halide, followed by Thorpe-Ziegler-cyclization yields differently substituted, support-bound 3-aminothiophenes. These may be screened on the substrate or cleaved from the substrate and then screened in solution. Alternatively, the resin-bound 3-amino thiophenes or the synthetic intermediates can be subjected to further synthetic transformations (N-acylation, reduction) on the support, which permits the preparation of further therapeutically interesting compounds. The efficient synthesis of a wide variety of thiophenes using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiophene-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:WO-9740025-A1
优先权日:1996-04-19
标 题 :Solid phase and combinatorial synthesis of substituted 1,2,3-triazoles and of arrays of substituted 1,2,3-triazoles
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS; DOERWALD FLORENCIO ZARAGOZA
摘要:A solid phase method for the synthesis of a plurality of differently substituted 1,2,3-triazoles with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The 1,2,3-triazoles are prepared by acylation of a substrate-bound primary or secondary amine with a 3-oxoalkanoic acid and reaction of the resulting amide with a primary amine under dehydrating conditions to give an enamine. Treatment of this substrate-bound enamine with a sulfonyl azide in the presence of a base gives the corresponding 1,2,3-triazoles. These may be screened on the substrate or cleaved from the substrate and then screened in solution. The efficient synthesis of a wide variety of 1,2,3-triazoles using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse triazole-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:US-11938187-B2
优先权日:2021-06-10
标题:Methods and compositions for synthesis of two-photon cleavable phosphoramidite molecules for oligonucleotide conjugation
发明人：LO PEGGY PIK KWAN; LIU LING SUM; TAM DICK YAN
权利人:UNIV CITY HONG KONG
摘要:The syntheses of two phosphoramidite building blocks based on BNSF and BNSMB structures are disclosed. Furthermore, some common molecular intermediates have been designed and linked to the central biphenyl core of the two molecules, resulting in a versatile and cost-effective design. These compounds can be effectively introduced to DNA oligonucleotides via the well-established standard cyanoethylphosphoramidite chemistry on the nucleic acid synthesizer. Fragmentation of these BNSF- and BNSMB-functionalized DNA strands is achieved by both one-photon and two-photon photolysis of photoliable bonds of [2-(2-nitrophenyl)propoxy]carbonyl groups on BNSF and BNSMB molecules respectively, resulting in two short pieces of single-stranded DNAs. The versatile design and facile synthesis of these two-photon photocleavage phosphoramidite molecules are beneficial to synthetic chemists and photochemists for the development of new caged compounds which enables to introduce into oligonucleotides as light-triggered carriers via solid-phase synthesis for a wide range of applications in materials science, polymer, chemistry, biology and DNA nanoecthnology.

专利号:US-2024383836-A1
优先权日:2022-01-28
标 题:Synthesis of multi-ring disalicylate linkers
发明人：KAPELEWSKI MATTHEW T; WESTON SIMON C; FALER CATHERINE A
权利人:EXXONMOBIL TECHNOLOGY & ENGINEERING COMPANY
摘要:Systems and methods are provided for synthesizing multi-ring disalicylate linkers. The systems and methods can allow for synthesis of disalicylate linkers while using a reduced or minimized amount of solvent (such as down to potentially having no separate solvent) in the reaction environment. The synthesis can be performed by starting with a compound such as 4,4′-biphenol as a starting reagent. The 4,4′-biphenol (and/or other alcohol-substituted biphenyl compound) can then be exposed in a reaction environment to pressurized CO 2 in the presence of a base. The temperature and pressure in the reaction environment can be increased to achieve either supercritical conditions for the CO 2 (based on a phase diagram for neat CO 2 ) and/or sub-critical conditions that are substantially similar to supercritical conditions. This can allow for conversion of the 4,4′-biphenol (or other alcohol-substituted biphenyl compound) into a multi-ring disalicylate linker.

专利号:US-7999129-B2
优先权日:2004-02-13
标 题:Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and its application in the synthesis of agomelatine
发明人：SOUVIE JEAN-CLAUDE; BLANCO ISAAC GONZALEZ
权利人:SERVIER LAB
摘要:A process for the industrial synthesis of the compound of formula (I) n nApplication in the synthesis of agomelatine.