CAS: 124401-38-3; 4-Methyl-3-Oxo-N-Phenylpentanamide

相似化合物

25233-46-9 124401-38-3 4433-78-7

上下游产品

N-乙酰乙酰苯胺 N-Phenylacetoacetamide 102-01-2

Tert-Butyl (2-((5-Methyl-4-Oxo-3-(Phenylcarbamoyl)Hex-2-En-2-yl)Amino)Ethyl)Carbamate置于三氟乙酸体系中,用 二氯甲烷 用作溶剂,化学反应 0.67H,以88%的收率获得4-甲基-3-酮基-N-苯基戊酰胺
参考文献:基于烯胺的多米诺策略用于乙酰乙酰胺的 C-酰化/脱乙酰:β-酮酰胺的实际合成
标题:基于烯胺的多米诺策略用于乙酰乙酰胺的 C-酰化/脱乙酰:β-酮酰胺的实际合成
摘要:描述了乙酰乙酰胺的 C-酰化/脱乙酰化的实用三步路线.乙酰乙酰胺与 Boc 单保护乙二胺的初始烯化提供 β-烯氨基酰胺,其在 α-碳上以优异的选择性酰化.C-酰化衍生物在酸性介质中发生多米诺断裂,得到相应的α-酮酰胺,并伴随有 2-甲基-4,5-二氢-1H-咪唑.
Doi:10.1055/s-0029-1219836

专利信息

专利号:US-8124790-B2
优先权日:2008-01-02
标题:Preparation process useful in synthesis of atorvastatin
发明人：CHO DONG-OCK; KWON YOUNJA; CHA KYEONG-HOI; KIM YEONGSOOK; TAE HYUN-SEOP
权利人:CHO DONG-OCK; KWON YOUNJA; CHA KYEONG-HOI; KIM YEONGSOOK; TAE HYUN-SEOP; MEDICHEM KOREA CO LTD
摘要:The present invention relates to a preparation process useful in synthesis of atorvastatin, more particularly a process for preparing atorvastatin is effective in treating hyperlipemia, comprising protecting the dihydroxy group at C3 and C5 positions of the starting material cis-t-butyl-6-substituted-3,5-dihydroxy-hexanoate with trialkyl orthoformate, reducing the terminal nitro or cyano group to amine group, performing JV-alkylation by sequentially reacting with ethyl 4-fluorobenzene-2-haloacetate and isobutyryl chloride, cyclizing with JV,3-diphenylpropynamide, and performing deprotection and hydrolysis.

专利号:US-6867306-B2
优先权日:2001-01-19
标题:Process for the synthesis of atorvastatin form v and phenylboronates as intermediate compounds
发明人：SRINATH SUMITRA; MATHEW JOY; UJIRE SANDHYA; SRIDHARAN MADHAVAN; SAMBASIVAM GANESH
权利人:BIOCON LTD
摘要:The present invention discusses a novel process for the synthesis of [R-(R*,R*)]-2-(4-fluorophenyl)-B,D-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium, atorvastatin. The compound so prepared is useful as inhibitor of the HMG-CoA reductase and may thus be used as hypolipidemic and hypocholesterolemic agent.

专利号:US-5998633-A
优先权日:1996-07-29
标 题:Process for the synthesis of protected esters of (S)-3,4-dihydroxybutyric acid
发明人：JACKS THOMAS E; BUTLER DONALD E
权利人:WARNER LAMBERT CO
摘要:The invention is an improved process for the preparation of a compound of formula I wherein R and R 1 are each independently alkyl of from 1 to 3 carbon atoms; and R 2 is alkyl of from 1 to 8 carbon atoms. ##STR1##

专利号:US-5155251-A
优先权日:1991-10-11
标题:Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
发明人：BUTLER DONALD E; LE TUNG V; MILLAR ALAN; NANNINGA THOMAS N
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate is described where a halo hydroxyester or other activated dihydroxyester is converted in two steps to the desired product.

专利号:US-5248793-A
优先权日:1990-10-17
标 题:Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
发明人：MILLAR ALAN; BUTLER DONALD E
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of (4R-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate is described where a hydroxy ester derivative is converted in two steps to the desired product, as well as valuable intermediates used in the process.

专利号:US-5103024-A
优先权日:1990-10-17
标题:Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
发明人：MILLAR ALLAN; BUTLER DONALD E
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of (4R-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate is described where a hydroxy ester derivative is converted in two steps to the desired product, as well as valuable intermediates used in the process.