CAS: 128607-22-7; 2-[4-[(Z)-4-Chloro-1,2-Diphenylbut-1-Enyl]Phenoxy]Ethanol

上下游产品

CAS号936-59-4 3-氯代苯丙酮 | CAS号14814-17-6 (4-(2-羟基乙氧基)苯基)... | CAS号177989-80-9 (Z)-(1-(4-(2-(b... | CAS号89778-41-6 Phenol, 4-[(1Z)... | CAS号96388-83-9 四氢-2-(2-碘乙氧基)-2H-吡喃 | CAS号341527-08-0 (Z)-[4-(4-Chlor... | CAS号58214-99-6 2-phenoxyethyl ... | CAS号65-85-0 苯甲酸 | CAS号122-99-6 乙二醇苯醚

(Z)-(1-(4-(2-(Benzyloxy)Ethoxy)Phenyl)-4-Chlorobut-1-Ene-1,2-Diyl)Dibenzene置于钯 氢气,钯,乙醇,水体系中,用 乙酸乙酯,乙醇 用作溶剂,化学反应生成欧司哌米
参考文献:Triphenylethylenes For The Prevention And Treatment Of Osteoporosis
标题:Triphenylethylenes For The Prevention And Treatment Of Osteoporosis
摘要:具有公式(i)的化合物,其中r.Sub.1和r.Sub.2独立地为h或oh,对于骨质疏松症的治疗和预防是有用的.公式(i)的化合物不具有明显的抗雌激素和雌激素活性.##str1##

专利信息

专利号:US-11873305-B2
优先权日:2020-06-30
标题 :Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds
发明人：ZHANG HAIMING; XU JIE; WUITSCHIK GEORG; ANGELAUD REMY; HEROLD SEBASTIAN; STUTZ ALFRED; BRUETSCH TOBIAS; BURKHARD JOHANNES
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are processes for the preparation of indolyl intermediates using Wenker Synthesis for the total synthesis of SERD compounds useful in the treatment of cancer.

专利号:US-12043612-B2
优先权日:2020-05-09
标 题 :Methods of manufacturing a bifunctional compound, ultrapure forms of the bifunctional compound, and dosage forms comprising the same
发明人：ALLAN LAURA E N; CHEN CHUNGPIN HERMAN; DONG HANQING; GROSSO JOHN A; HASKELL III ROYAL J; LLOYD RHYS; REECE HAYLEY
权利人:ARVINAS OPERATIONS INC
摘要:The present disclosure relates to ultra-pure forms, polymorphs, amorphous forms, and formulations of N-[(1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-({4-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]piperazin-1-yl}methyl)piperidin-1-yl]pyridazine-3-carboxamide, referred to herein as Compound A:The present disclosure also relates methods of manufacturing and purifying the same, as well as intermediates useful in the synthesis of Compound A. The ultra-pure forms, polymorphs, amorphous forms, and formulations of Compound A can be used as therapeutic agents for the treatment of various diseases and conditions such as cancer.

专利号:US-9975832-B2
优先权日:2014-12-29
标题:Process for the preparation of ospemifene and fispemifene
发明人：CRISTIANO TANIA; ALPEGIANI MARCO
权利人:OLON SPA
摘要:Disclosed is a process for the synthesis of the active ingredients ospemifene and fispemifene which comprises reacting phenol 4 with an alkylating agent X—CH 2 CH 2 —Y of formula 7, wherein X is a leaving group and Y is the —(OCH 2 CH 2 ) n OH group wherein n is zero or 1; or X and Y, taken together, represent an oxygen atom; to give ospemifene or fispemifene of formula 8.

专利号:US-2024174678-A1
优先权日:2020-06-30
标 题 :Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds

专利号:US-11780834-B2
优先权日:2018-06-21
标题:Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3- yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use
发明人：CHUNG CHEOL KEUN; XU JIE; IDING HANS; CLAGG KYLE; DALZIEL MICHAEL; FETTES ALEC; GOSSELIN FRANCIS; LIM NGIAP-KIE; MCCLORY ANDREW; ZHANG HAIMING; CHAKRAVARTY PAROMA; NAGAPUDI KARTHIK; ROBINSON SARAH
权利人:HOFFMANN LA ROCHE; GENENTECH INC
摘要:Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.

专利号:JP-7273802-B2
优先权日:2017-08-28
标题 :Asymmetric Synthesis of Compounds and Use in Disease Treatment