CAS: 13504-85-3; (2S,4R)-1-((Benzyloxy)Carbonyl)-4-Hydroxypyrrolidine-2-Carboxylic Acid

上下游产品

CAS号501-53-1 氯甲酸苄酯 | CAS号51-35-4 L-羟脯氨酸 | CAS号85201-91-8 (2S,4R)-1-((苄氧基... | CAS号117811-78-6 (2S,4R)-Cbz-4-甲... | CAS号7536-89-2 trimethylsilyl ... | CAS号64187-47-9 (S)-1-((苄氧基)羰基)... | CAS号473806-21-2 (2S,4R)-4-(叔丁氧基... | CAS号3326-64-5 trans 4-Hydroxy... | CAS号32563-24-9 L-erythro-4-氟谷氨酸 | CAS号95687-41-5 Cbz-反式-4-羟基-L-脯氨醇 | CAS号64187-48-0 N-CBZ-羟脯氨酸甲酯 | CAS号64769-66-0 L-反式-吡咯烷-2,4-二羧酸 | CAS号64187-47-9 (S)-1-((苄氧基)羰基)... | CAS号72180-14-4 (2S,4S)-4-氟-1,2... | CAS号130830-73-8 (2S,4S)-1-(benz... | CAS号618-27-9 顺式-4-羟基-L-脯氨酸

(4R)-(叔丁氧基)-1-(苯甲氧羰基)-L-脯氨酸置于三乙基硅烷,三氟乙酸体系中,用 二氯甲烷 用作溶剂,化学反应 0.58H,以100%的收率获得cbz-L-羟脯氨酸
参考文献:肽合成中提高的效率和选择性:三乙基硅烷作为碳阳离子清除剂在叔丁酯和叔丁氧羰基保护位点的脱保护中的用途
标题:肽合成中提高的效率和选择性:三乙基硅烷作为碳阳离子清除剂在叔丁酯和叔丁氧羰基保护位点的脱保护中的用途
摘要:在二氯甲烷中存在三氟乙酸的情况下,使用三乙基硅烷作为碳正离子清除剂可提高收率,减少反应时间,简化后处理并提高对受保护氨基酸中叔丁酯和叔丁氧羰基位点进行脱保护的选择性在其他对酸敏感的保护基如苄氧羰基,9-芴基甲氧羰基,O-和s-苄基和叔丁硫基存在下的肽.
Doi:10.1016/s0040-4039(00)79116-7

专利信息

专利号:US-5419966-A
优先权日:1991-06-10
标 题 :Solid support for synthesis of 3'-tailed oligonucleotides
发明人：REED MICHAEL W; MEYER JR RICH B; PETRIE CHARLES R; TABONE JOHN C
权利人:MICROPROBE CORP
摘要:A solid support for oligonucleotide synthesis has the structure where CPG represents a controlled pore glass matrix, the wavy line represents a carbon chain covalently linking the NH group with the controlled pore glass matrix, X is 2,2'-dimethoxytrityl or H, and R is alkyl, aryl, arylalkyl, heteroalkyl, or heteroaryl. The dimethoxytrityl group is removed from the solid support by treatment with acid, and the oligonucleotide is built, step-by-step in a conventional synthesizer after attachment of the 3' end of the first oligonucleotide unit to the hydroxyl function connected to the R group.

专利号:US-9469609-B2
优先权日:2006-12-21
标 题:Synthesis of pyrrolidine compounds
发明人：ALIMARDANOV ASAF R; KRISHNAN LALITHA; ZHOU MAOTANG; WANG TING-ZHONG; REN JIANXIN; CONSIDINE JOHN LEO; WU CHARLES C; BRAZZILLO JASON; RAVEENDRANATH PANOLIL; SUTHERLAND KAREN; MIRMEHRABI MAHMOUD; DESHMUKH SUBODH S
权利人:ZEALAND PHARMA AS
摘要:Provided are methods for the preparation of certain substituted pyrrolidine compounds, forms of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride, and methods for preparing and using these forms.

专利号:US-8378099-B2
优先权日:1994-10-28
标 题:Boronic ester and acid compounds, synthesis and uses
发明人：ADAMS JULIAN; MA YU-TING; STEIN ROSS L; BAEVSKY MATTHEW; GRENIER LOUIS; PLAMONDON LOUIS
权利人:MILLENNIUM PHARMACUETICALS INC; ADAMS JULIAN; STEIN ROSS L; BAEVSKY MATTHEW; GRENIER LOUIS; PLAMONDON LOUIS
摘要:Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.

专利号:US-2008188545-A1
优先权日:2006-12-21
标题 :Synthesis of pyrrolidine compounds

专利号:US-2013053344-A1
优先权日:2006-12-21
标 题:Synthesis of pyrrolidine compounds

专利号:WO-9203464-A1
优先权日:1990-08-28
标题 :Solid support synthesis of 3'-tailed oligonucleotides via a linking molecule