CAS: 185629-31-6; Methyl 3-Fluoro-4-Nitrobenzoate

上下游产品

methanol 3-fluoro-4-nitrobenzoic acid 3-fluoro-4-nitrobenzoyl chloride N-trimethylsilylmethylamine3-(4-chloro-phenoxy)-4-nitro-benzoic acid methyl ester 4-amino-3-(4-chloro-phenoxy)-benzoic acid methyl ester 4-amino-3-(4-chloro-phenoxy)-5-iodo-benzoic acid methyl ester H-carbazole-3-carboxylic acid methyl ester1-(4-chloro-phenoxy)-9H-carbazole-3-carboxylic acid methyl ester

3-氟-4-硝基甲苯置于氯化亚砜,Sodium Dichromate,硫酸体系中,用 水 用作溶剂,化学反应 18.5H,反应生成3-氟-4-硝基苯甲酸甲酯
参考文献:新型咔唑衍生物作为npy Y1拮抗剂.
标题:新型咔唑衍生物作为npy Y1拮抗剂.
摘要:描述了一系列咔唑衍生物及其在npy Y1受体上的sar的合成.通过适当的修饰来调节理化特性可导致鉴定出高亲和力的npy Y1拮抗剂,该拮抗剂具有较高的脑渗透能力和适度的口服生物利用度.
Doi:10.1016/j.Bmcl.2006.11.034

专利信息

专利号:WO-2025077857-A1
优先权日:2023-10-13
标题:Use of prmt5 inhibitor in treatment of tumors or cancers
发明人：YAO BING; GU XIAOHUI; MAO WEIFENG; ASWAD FRED JULLIEN; JOSEPH JAMES DAVID; LI MINGXI
权利人:SHANGHAI APEIRON THERAPEUTICS COMPANY LTD
摘要:The present disclosure describes a novel molecule having protein arginine methyltransferase 5 inhibitory activity, and methods for synthesis and use of a compound. Specifically, the present disclosure describes a compound of formula (I) or a pharmaceutically acceptable salt, hydrate or solvate thereof, and methods for synthesis and use of the compound.

专利号:WO-2024067445-A1
优先权日:2022-09-26
标 题 :Novel prmt5 inhibitor and use thereof
发明人：YAO BING; GU XIAOHUI; ZHANG JUNQING; XIE SHANSHAN; CHENG KAI
权利人:SHANGHAI APEIRON THERAPEUTICS COMPANY LTD
摘要:Provided are a compound of formula (I) having inhibitory activity for protein arginine methyltransferase 5, and a method for synthesis and use of the compound.