CAS: 203661-69-2; Tert-Butyl 2-Oxo-7-Azaspiro[3.5]Nonane-7-Carboxylate

相似化合物

1392211-51-6 147610-98-8 2306268-80-2

上下游产品

CAS号159635-49-1 N-B°C-4-亚甲基哌啶 | CAS号76-02-8 三氯乙酰氯 | CAS号203662-66-2 2-氰基-7-氮杂螺[3.5]... | CAS号240401-28-9 2-羟基-7-氮杂螺[3.5]... | CAS号1239319-82-4 2-氨基-7-b°C-7-氮杂...

在 氯化铵,锌体系中,用 甲醇 用作溶剂,以72%的收率获得2-氧代-7-氮杂螺[3.5]壬烷-7-甲酸叔丁酯
参考文献:氮杂螺环类化合物及其制备方法和应用
标题:氮杂螺环类化合物及其制备方法和应用
摘要:本发明公开了一种氮杂螺环类化合物及其制备方法和应用,属于药物化学领域.本发明的具有式i结构特征的氮杂螺环类化合物或其药学上可接受的盐或立体异构体或溶剂化物或前药,能够与autotaxin结合并作为autotaxin抑制剂,进而能够应用于预防和治疗具有autotaxin表达增加的病理学特征的疾病,例如癌症,纤维化疾病,尤其是肺纤维化和肝纤维化,代谢疾病,骨髓增生异常综合征,心血管疾病,自身免疫性疾病,炎症,神经系统疾病或疼痛等.该系列化合物与单一抑制剂相比,在各类关键信号通路上游进行阻断和干扰,减轻或延缓肿瘤细胞的生长和转移,可以避免药物过早出现耐药性,同时对肿瘤细胞的治疗提供新的可能.

专利信息

专利号:US-2022073513-A1
优先权日:2018-12-29
标题:1h-pyrrolo[2,3-b]pyridine derivatives and related compounds as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases
发明人：CHEN YI
权利人:NEWAVE PHARMACEUTICAL INC
摘要:The present invention relates to compounds of Formula (II) and more preferably to 1H-pyrrolo[2,3-b]pyridine derivatives of formula (III) and related compounds. The variables are defined in the claims. The compounds are BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis of exemplary compounds as well as pharmacological data thereof (pages 61 to 72; examples 1 to 4; tables). An exemplary compound is e.g. 4-(4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl]piperazin-1-yl)-2-[methyl(1H-pyrrolo[2,3-b]pyridin-5-yl)phosphoroso]-N-[3-nitro-4-[(oxan-4-yl methyl)amino]benzenesulfonyl]benzamide (example 1).

专利号:WO-2024041503-A1
优先权日:2022-08-22
标 题:Compounds targeting y220c mutant of p53
发明人：LI SUJING; LI AMIN; ZHENG QIAN; Dang Chaojie; FAN XINRUI; LONG WEI; WANG YANPING
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:The present invention discloses compounds of formula (I) which can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. Also provided are processes for the synthesis and use of the compounds of formula (I).

专利号:US-2023119463-A1
优先权日:2019-12-27
标题 :1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases
发明人：CHEN YI
权利人:NEWAVE PHARMACEUTICAL INC
摘要:The present invention relates to 1H-pyrrolo[2,3-b]pyridine derivatives and related compounds as BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 162 to 233; examples 1 to 8; table; compound examples cpd-1 to cpd-135; biological examples 1 to 4).

专利号:US-11299484-B2
优先权日:2018-10-10
标 题 :Inhibiting fatty acid synthase (FASN)
发明人：MARTIN MATTHEW W; ZABLOCKI MARY-MARGARET; MENTE SCOT; DINSMORE CHRISTOPHER; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:FORMA THERAPEUTICS INC
摘要:The present disclosure is directed to inhibitors of FASN. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of FASN. For instance, the disclosure is concerned with compounds and compositions for inhibition of FASN, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of FASN, and methods of synthesis of these compounds.

专利号:WO-2021133817-A1
优先权日:2019-12-27
标题 :1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases
发明人：CHEN YI
权利人:GUANGZHOU LUPENG PHARMACEUTICAL COMPANY LTD; NEWAVE PHARMACEUTICAL INC
摘要:The present invention relates to lH-pyrrolo[2,3-b]pyridine derivatives and related compounds as BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 162 to 233; examples 1 to 8; table; compound examples cpd-1 to cpd-135; biological examples 1 to 4).

专利号:CN-114560801-A
优先权日:2022-02-20
标题 :Method for photocatalytic synthesis of 3-cyanoalkyl-4-pyrroline-2-one and derivatives thereof