专利号:US-10604540-B2 优先权日:2016-09-16 标题 :Controlled synthesis of polymeric perylene diimide and applications thereof 发明人:MAZAHERIPOUR AMIR; BURKE ANTHONY; GORODETSKY ALON 权利人:UNIV CALIFORNIA 摘要:Perylene diimide phosphoramidite derivatives and methods for polymerization of perylene diimide phosphoramidite derivatives and applications thereof are provided. Compounds comprise at least an electronically active base surrogate and may also include a solubilizing functionality. The base surrogate may be comprised of an electrochemically active perylene diimide (PDI) molecule, the solubility chain may comprise a PEG functionality, and the PDI may further comprise a phosphoramidite functionality as an imide substituent. The phosphoramidite functionality may be used as a chemical coupling handle for use with established nucleic acid synthesis protocols and/or automated synthesis. One or more aromatic core functionalizations may be incorporated into the PDI molecules to allow for tuning the molecule's electronic and optical properties. One or more functional terminal groups may be incorporated into the PDI molecules, such as, for example terminal thiols for attachment to gold substrates and terminal ferrocenes for electrochemical measurements, among others.
专利号:WO-2025097020-A1 优先权日:2023-11-02 标题:Process for polyethylene glycol synthesis 发明人:WANG PENG; ZHANG CHENGZHI; GUO ZHIWEI; SONG LICHENG 权利人:DESIGN THERAPEUTICS INC 摘要:The present disclosure relates to a process for the synthesis of polyethylene glycol (PEG) derivatives.
专利号:US-11718596-B2 优先权日:2014-03-19 标题 :Amyloid targeting agents and methods of using the same 发明人:YANG JERRY; THEODORAKIS EMMANUEL A; SARRAF STELLA 权利人:UNIV CALIFORNIA; AMYDIS INC 摘要:Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.
专利号:US-2010184989-A1 优先权日:2007-03-12 标 题 :De Novo Synthesis of Conjugates 发明人:RIGGS-SAUTHIER JENNIFER; DENG BO-LIANG; REN ZHONGXU; ZHANG WEN; GU XUYUAN; DUARTE FRANCO J 权利人:NEKTAR THERAPEUTICS 摘要:The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path.
专利号:EP-1430082-A4 优先权日:2001-09-07 标 题 :SYNTHESIS OF POLYPEPTIDE-OLIGOMERIC CONJUGATES OF INSULIN, AND POLYPEPTIDE-OLIGOMERIC CONJUGATES OF PROINSULIN, AND METHODS OF THEIR SYNTHESIS
专利号:US-2019010175-A1 优先权日:2016-09-16 标题 :Controlled Synthesis of Polymeric Perylene Diimide and Applications Thereof
1: Brown A, Patel S, Ward C, Lorenz A, Ortiz M, DuRoss A, Wieghardt F, Esch A, Otten EG, Heiser LM, Korolchuk VI, Sun C, Sarkar S, Sahay G. PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder. Sci Rep. 2016 Aug 30;6:31750. doi: 10.1038/srep31750. 2: Saifer MG, Williams LD, Sobczyk MA, Michaels SJ, Sherman MR. Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins. Mol Immunol. 2014 Feb;57(2):236-46. doi: 10.1016/j.molimm.2013.07.014. Epub 2013 Nov 5. doi: 10.1517/17425247.2012.720969. Epub 2012 Aug 30.
合成参考文献
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