CAS: 28875-17-4; Boc-Ala-Ome

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2-叔丁氧羰基氨基丙烯酸甲酯置于rh(1+)*2Ch4O*c4H12B(1-)*c34H40O2P2,氢气体系中,用 甲醇 用作溶剂,22.0 °C,100.0 Kpa 条件下,反应 0.07H,以100%的收率获得boc-L-丙氨酸甲酯
参考文献:α-芳基-和α-Carboxyamidoethylenes的实际不对称加氢由铑(i)-{1,2-双[(ø-叔-Butoxyphenyl)(苯基)膦基]乙烷}
标题:α-芳基-和α-Carboxyamidoethylenes的实际不对称加氢由铑(i)-{1,2-双[(ø-叔-Butoxyphenyl)(苯基)膦基]乙烷}
摘要:铑(i)-{1,2-二[(ø-叔-Butoxyphenyl)(苯基)膦基〕乙烷}的[rh(i)-(叔卜-Sms-Phos)]的催化剂体系显示优越的效率大系列α-酰胺基苯乙烯和α-酰胺基丙烯酸酯的氢化.在22oc的甲醇中,在1-10 Bar的氢气下,常规操作可获得高达> 99.9%的对映异构体过量以及极高的反应速率.实例包括工业基材.
Doi:10.1002/adsc.201200780

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.