CAS: 536-38-9; 2-Bromo-4'-Chloroacetophenone

上下游产品

CAS号99-91-2 对氯苯乙酮 | CAS号33491-03-1 1-bromo-2-(4-ch... | CAS号1073-67-2 对氯苯乙烯 | CAS号622-98-0 1-氯-4-乙基苯 | CAS号3391-10-4 4-氯苯基-1-乙醇 | CAS号6314-52-9 2-bromo-1-(4-ch... | CAS号141-78-6 乙酸乙酯 | CAS号13651-12-2 2,2-二溴-1-(4-氯苯基)乙酮 | CAS号22118-09-8 溴乙酰氯 | CAS号108664-34-2 3-[3-(4-chlorop... | CAS号104940-96-7 1-[3-(4-chlorop... | CAS号104941-02-8 1-[3-(4-chlorop... | CAS号111808-94-7 5-(4-氯苯基)-3-羟基甲... | CAS号104941-03-9 1-[1-(4-chlorop... | CAS号104940-98-9 5-chloro-1-[3-(... | CAS号108664-36-4 2-[3-(4-chlorop... | CAS号104941-04-0 1-[3-(4-chlorop... | CAS号106314-72-1 2-[1-[2-(4-chlo... | CAS号108664-29-5 3-[3-(4-chlorop...

对氯苯乙酮置于氢溴酸体系中,用 乙腈 作为反应溶剂,以89%的收率获得产物2'-溴-4-氯苯乙酮
参考文献:合成 α-溴代烷基芳基酮的简便电化学方法
标题:合成 α-溴代烷基芳基酮的简便电化学方法
摘要:已经报道了一种以优异的产率对烷基芳基酮进行有效 α-溴化的电化学方法.该方法的优点是实验过程简单,无催化剂转化,单溴化产物收率高.
DOI:10.1080/00397910903161710

专利信息

专利号:WO-2021038581-A1
优先权日:2019-08-30
标题 :A one step synthesis of 2-substituted benzo[b]thiophenes
发明人：SEKAR GOVINDASAMY; POONGUZHALI ELAMVAZHUTHI
权利人:INDIAN INST TECH MADRAS
摘要:The invention pertains to a one step synthesis of 2-substituted benzo[ b ]thiophene of general formula wherein the synthesis of 2-substituted benzo[ b ]thiophenes is by reacting the starting materials substituted or unsubstituted 2-halogenobenzaldehyde and substituted or unsubstituted acetyl/phenacyl bromide with a catalyst, a sulphur source and phase transfer catalyst in an aqueous medium with atmospheric air and at temperature in the range of 25°C-30°C.

专利号:US-5399721-A
优先权日:1990-01-12
标题:Synthesis of optically pure 4-aryl-2-hydroxytetronic acids
发明人：HOPPER ALLEN T; WITIAK DONALD T
权利人:UNIV OHIO STATE RES FOUND
摘要:The present invention relates to a method for synthesis of optically pure stereogenically labile 4-aryl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase. the invention further relates to the pharmaceutical use of such compounds in the treatment of coronary artery diseases, especially in the treatment and/or prevention of atherosclerosis.

专利号:US-2004267028-A1
优先权日:2001-09-24
标题 :Preparation and use of pyrrole derivatives for treating obesity
发明人：SMITH ROGER A; KLUENDER HAROLD C; SU NING; LAVOIE RICO C; FAN JIANMEI
权利人:SMITH ROGER A; KLUENDER HAROLD C; SU NING; LAVOIE RICO C; FAN JIANMEI
摘要:This invention relates to pyrrole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

专利号:US-7816375-B2
优先权日:2000-09-11
标 题 :Ligands for monoamine receptors and transporters, and methods of use thereof
发明人：AQUILA BRIAN M; BANNISTER THOMAS D; CUNY GREGORY D; HAUSKE JAMES R; HOLLAND JOANNE M; PERSONS PAUL E; RADEKE HEIKE; WANG FENGJIANG; SHAO LIMING
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.

专利号:US-7807837-B2
优先权日:2004-05-07
标 题 :Scalable synthesis of imidazole derivatives
发明人：JONES TODD K; MANI NEELAKANDHA
权利人:JANSSEN PHARMACEUTICA NV
摘要:Imidazole derivatives, compositions containing them, methods of preparing them, including regioselective scale-up synthetic methods, and methods of using them.

专利号:US-7217823-B2
优先权日:2000-12-06
标题:4,4-Disubstituted piperidines, and methods of use thereof
发明人：HOEMANN MICHAEL Z
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, analgesia, schizophrenia, Parkinson's disease, restless leg syndrome, sleeping disorders, attention deficit hyperactivity disorder, irritable bowel syndrome, premature ejaculation, menstrual dysphoria syndrome, urinary incontinence, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.