专利号:US-6229055-B1 优先权日:1996-04-12 标题 :Synthesis of fluorinated xanthene derivatives 发明人:KLAUBERT DIETER H; GEE KYLE R 权利人:MOLECULAR PROBES INC 摘要:Facile syntheses for fluorinated resorcinol and aminophenol derivatives are provided that yield isomer-free products in good yield. These novel methods use generally available precursors and standard laboratory reagents and equipment to reproducibly produce these synthetically useful reagents in relatively large quantities. The resulting fluorinated resorcinols and aniinophenols possess utility in the preparation of fluorinated fluorescein and rhodol dyes.
专利号:WO-9509170-A1 优先权日:1993-09-28 标 题:Chemical synthesis of rhodamine derivatives 发明人:CORRIE JOHN EDGAR THOMAS; CRAIK JAMES STANLEY 权利人:MEDICAL RES COUNCIL; CORRIE JOHN EDGAR THOMAS; CRAIK JAMES STANLEY 摘要:A method for preparing rhodamine derivatives of formulae (a) or (b) or a mixture of such compounds, where X is bromo, chloro- or iodoacetamido, maleimido, or amino. These compounds are the 5 and 6 (or 5' and 6') isomers of the amine, haloacetamide and maleimide derivatives of tetramethylrhodamine. The method enables for the first time the production of isomerically pure compounds on a relatively large scale. The products are fluorescent and are useful for the labelling of proteins.
专利号:US-4002664-A 优先权日:1973-06-09 标题 :Manufacture of dimethylaminobenzenecarboxylic acid esters 发明人:QUADBECK-SEEGER HANS-JUERGEN; HOCH HELMUT 权利人:BASF AG 摘要:Dimethylaminobenzenecarboxylic acid esters are produced by reaction of nitrobenzenecarboxylic acid esters with formaldehyde and hydrogen under pressure in the presence of a hydrogenation catalyst containing metals of atomic numbers 24 to 29 and of a weak acid, at temperatures from 35° to 150° C. The products are starting materials for the synthesis of dyes, especially of crystal violets, and of reactive dyes and pesticides.
专利号:US-6251354-B1 优先权日:1999-04-02 标 题:Process for recovering sodium nitrite 发明人:GREENWELL ROBERT E; GUGGENHEIM THOMAS LINK; JOHNSON NORMAN ENOCH; ODLE ROY RAY; WEBB JIMMY LYNN 权利人:GEN ELECTRIC 摘要:The present invention provides a process for recovering a metal nitrite, e.g., sodium nitrite, from a reaction mixture formed from an aromatic displacement reaction such as the synthesis of an aromatic bis(ether phthalimide) in an organic non-polar solvent. The process comprises forming a reaction mixture from the synthesis of an aromatic bis(ether phthalimide) comprising a recoverable amount of metal nitrite; treating the reaction mixture with an amount of water effective to produce an aqueous solution phase of metal nitrite and an organic non-polar phase; and separating the aqueous solution phase of metal nitrite from the organic non-polar phase.
专利号:US-11884714-B2 优先权日:2019-03-01 标 题:Cyclic peptide analogs of melanocortin and amanitin and methods of making such 发明人:PERRIN DAVID; TODOROVIC MIHAJLO; BÉNARD FRANÇOIS; ZHANG CHENGCHENG 权利人:UNIV BRITISH COLUMBIA; PROVINCIAL HEALTH SERVICES AUTHORITY 摘要:The invention described herein is based in part on the discovery of a protein/peptide crosslink, which introduces fluorescent properties, and which has been applied to synthesize analogues of melanocortin and amanitin as choice peptides to be explored in the context of isoindole peptides. Without limitation, it is expected that those trained in the art of peptide synthesis and stapling would appreciate the consequences of this invention such that other peptides of varied length can be similarly constrained by isoindole staples as featured herein.
专利号:CN-106800519-A 优先权日:2017-02-08 标题 :General Method and Application of Rapid Synthesis of Bridged Bis, Tris and Tetraamide Derivatives by Ultrasonic Radiation
[参考文献]: Xiaoyong Wu, Et Al. Tissue-Specific Distribution And Activity Of Glutathione S-Transferases As Biomarkers In Bivalve Shellfishes. Water Environ Res. 2013 May;85(5):404-10.
合成参考文献
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