CAS: 89402-43-7; 5-Chloro-2,3-Difluoropyridine

• 英文名称5-Chloro-2,3-Difluoropyridine
• 中文名称2,3-二氟-5-氯吡啶
• IUPAC名称5-chloro-2,3-difluoropyridine
• 其它别名5-氯-2,3-二氟吡啶; 23二氟5氯吡啶; 2,3-Difuoro-5-Chloropyridine
• CAS编号89402-43-7
• MFCD编号:MFCD04039314
• EINECS号:410-090-7
• FDA UNII编号:NTR2GM7GHF
• 分子式:C5H2ClF2N
• 分子量:149.53
• 产品CID: 1915850
• 产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

• 相似结构搜索
• InChIKey: PERMDYZFNQIKBL-UHFFFAOYSA-N
• InChI=1S/C5H2ClF2N/c6-3-1-4(7)5(8)9-2-3/h1-2H…
• 计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数0.0

相似化合物

物理性质

• 熔点47-49 °C
• 沸点135-136°C at 760 mmHg
• 闪点135°C
• 密度1.5±0.1 g/cm3
• pKa:-5.14±0.20(预测)
• PSA:12.89
• LogP:2.0132
• 折射率1.479
• 蒸汽压7.0±0.3 mmHg at 25°C
• 溶解性Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• 敏感性按规定使用和贮存的不会分解，避氧化物
• 外观形态透明无色油状物
• 储存条件2-8°C
• 产品应用该化合物用于制造除草剂和农药,如胆碱酯酶.
• 性质描述白色液体.沸点210°C,密度1.442g/cm3,折光系数1.4738.

MSDS等安全信息

• GHS象形图
• GHS符号GHS02 & GHS07;
  注释: Flame & Exclamation mark
• 危险类别易燃液体 类别3
  急性毒性 类别4(经口)
  水生慢性毒性 类别3
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
• 警示词Warning(警告)
• 危险描述H226 |易燃液体和蒸气.
  H302 |吞咽有害.
  H412 |对水生生物有害并具有长期持续影响.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
• 防范说明P210-P233-P240-P241-P273
• 危险等级3
• UN编号1993.0
• 危险品标志Xi,Xn
• 风险等级Harmful
• 包装等级Ⅲ
• 安全声明23-36-61-26
• 危险类别码22-52/53-10-36/37/38-20/21/22
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 16063-70-0 = 89402-43-7
  反应条件:1.1 Reagents: Benzyltriethylammonium Chloride,Potassium Fluoride Solvents: Dimethyl Sulfoxide,Hexane; 6 H,150 °C
  标题:A Process For Preparing Fluoro-Containing Compounds
  参考文献:China]
  
  823-56-3 = 89402-43-7
  反应条件:1.1 Reagents: Potassium Carbonate,Cesium Fluoride Solvents: 1-Butyl-3-Methylimidazolium Tetrafluoroborate; 8 H,200 Mm Hg,100 - 110 °C
  标题:Direct Formation Of 2,3,5-Trichloropyridine And Its Nucleophilic Displacement Reactions In Ionic Liquid
  作者:Zhong,Ping; Hu,Huanan; Guo,Shengrong
  参考文献:Synthetic Communications 日期:2004 卷标:34(23) 页码:4301-4311]
  
  16063-70-0 = 89402-43-7
  反应条件:1.1 Reagents: Potassium Carbonate,Potassium Fluoride Catalysts: 18-Crown-6 Solvents: Sulfolane; 120 °C -> 200 °C; 3 H,200 °C
  标题:Synthesis Of 2,3-Difluoro-5-Chloropyridine
  作者:Zheng,Jing; Zhang,Hao; Zhou,Hong-Feng
  参考文献:Huaxue Shijie 日期:2007 卷标:48(7) 页码:425-427]
  
  16063-70-0 = 89402-43-7 [标题:Reaction Conditions
  标题:α,β- And β,γ-Difluoropyridine Compounds Employing Potassium Fluoride And/or Cesium Fluoride As The Fluorinating Agent
  参考文献:European Patent Organization]
  
  16063-70-0 = 89402-43-7 + 823-56-3
  反应条件:1.1 Reagents: Potassium Fluoride Catalysts: Tetraphenylphosphonium Bromide Solvents: Benzonitrile
  标题:Preparation Of Fluorinated Pyridines
  参考文献:Japan]
  
  16063-70-0 = 89402-43-7
  反应条件:1.1 Reagents: Potassium Fluoride Solvents: Toluene,Sulfolane; 2 H,Reflux1.2 Catalysts: Pyridinium,4-(Dimethylamino)-1-(Phenylmethyl)-,Chloride (1:1); 4 H,180 °C
  标题:Synthesis Of 2,3-Difluoro-5-Chloropyridine By Phase Transfer Catalysis
  作者:Wang,Yu; Chen,Qun; Sun,Fu-An; Liu,Chun-Yan; He,Ming-Yang
  参考文献:Huaxue Shiji 日期:2011 卷标:33(1) 页码:91-93]
  
  16063-70-0 = 89402-43-7 [标题:Reaction Conditions
  标题:Pyridyl(Oxy/thio)Phenoxy Compounds And Herbicidal Compositions
  参考文献:European Patent Organization]
  
  16063-70-0 = 89402-43-7 + 823-56-3
  反应条件:1.1 Reagents: Potassium Carbonate,Potassium Fluoride,Cesium Fluoride Catalysts: 18-Crown-6,Benzenemethanaminium,N,N,N-Triphenyl-,Chloride (1:1) Solvents: Toluene,Sulfolane,1,3-Dimethyl-3,4,5,6-Tetrahydro-2(1H)-Pyrimidinone; 8 H,Heated1.2 12 H,220 - 230 °C
  标题:Application Of New Blended Catalyst For Synthesizing Of Fluoro Intermediate In Herbicide Industries
  作者:Ahmadi,A.
  参考文献:Asian Journal Of Chemistry 日期:2009 卷标:21(9) 页码:6651-6655]
  
  = 89402-43-7 + 823-56-3
  反应条件:1.1 Reagents: 1-Butyl-3-Methylimidazolium Tetrafluoroborate Catalysts: Cuprous Chloride Solvents: Acetonitrile; 120 °C2.1 Reagents: Potassium Carbonate,Potassium Fluoride,Cesium Fluoride Solvents: 1-Butyl-3-Methylimidazolium Tetrafluoroborate; 10 H,200 °C
  标题:Direct Formation Of 2,3,5-Trichloropyridine And Its Nucleophilic Displacement Reactions In Ionic Liquid
  作者:Zhong,Ping; Et Al
  参考文献:Synthetic Communications 日期:2004 卷标:34(23) 页码:4301-4311

海关参考信息

• 2933310010-吡啶
  2939800000-其他生物碱
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

专利信息

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• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
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