CAS: 90-98-2; 4,4-Dichlorobenzophenone

该化合物是一种属于苯苯酮类别的有机化合物,其特征是结构结构,其特点是两个氯苯环,由碳基(C=O)组成;该化合物一般是白到光黄色晶状固体,以其在水中的溶解性相对较低而闻名,但在乙醇和乙酮等有机溶剂中的溶解性较高而闻名. 4,4欧元二氯苯苯苯酮主要用作各种应用中的紫外线过滤器,包括化妆品和塑料,因为它能够吸收紫外光;此外,该化合物还用于其他化学化合物的合成和作为制药的中间体,该化合物还因其对环境和健康的潜在影响而得到注意,需要小心处理和调节,在正常条件下,该化合物在工业应用中具有良好的溶解性,尽管由于其氯化性质,应当遵守安全措施.

英文名称4,4-Dichlorobenzophenone
中文名称4,4'-二氯二苯甲酮
IUPAC名称bis(4-chlorophenyl)methanone
其它别名p-Dichlorobenzophenone
CAS编号90-98-2
MFCD编号:MFCD00000623
EINECS号:202-030-1
FDA UNII编号:3MTL0YC2Q5
分子式:C13H8Cl2O
分子量:251.11
产品CID: 1944180
产品分类化学试剂 → 有机试剂 → 芳香酮

相似结构搜索
InChIKey: OKISUZLXOYGIFP-UHFFFAOYSA-N
InChI=1S/C13H8Cl2O/c14-11-5-1-9(2-6-11)13(16)10-3-7-12(15)8-4-10/h1-8H…
计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数2.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
严重眼刺激类别2
警示词Warning(警告)
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P280a-P304+P340-P305+P351+P338-P405-P501a
UN编号NONH for all modes of transport
危险品标志Xi
风险等级Irritant
安全声明22-24/25-36-26
危险类别码36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

diethyl ether methylammonium carbonate ethanol bis-(4-chlorophenyl)-dichloromethane bis(4-chlorophenyl)(pyridin-2-yl)methanol tetrakis-(4-chloro-phenyl)-ethane-1,2-diol 6,6-bis(4-chlorophenyl)fulvene bis(4-chlorophenyl)methanamine

合成工艺路线路线简述

合成目标产物 4,4'-Dichlorobenzophenone 主要起始原料 4,4'-Dichlorobenzhydrol
90-97-1 = 90-98-2
反应条件:1.1 Reagents: 4-Benzoylpyridine Solvents: Acetone; 32 H,Rt
标题:Photoinduced Oxidation Of Secondary Alcohols Using 4-Benzoylpyridine As An Oxidant
作者:Kamijo,Shin; Tao,Keisuke; Takao,Go; Tonoda,Hiroshi; Murafuji,Toshihiro
参考文献:Organic Letters 日期:2015 卷标:17(13) 页码:3326-3329]

101-76-8 = 90-98-2
反应条件:1.1 Reagents: Sodium Tert-Butoxide,Oxygen Solvents: Dimethyl Sulfoxide; 5 H,50 °C
标题:T-Buona-Mediated Transition-Metal-Free Autoxidation Of Diarylmethanes To Ketones
作者:Li,Jiang-Sheng; Yang,Fan; Yang,Qian; Li,Zhi-Wei; Chen,Guo-Qin; Et Al
参考文献:Synlett 日期:2017 卷标:28(8) 页码:994-998]

90-97-1 = 90-98-2
反应条件:1.1 Reagents: Perchloric Acid,Perchloric Acid,Thallium(3+) Salt Solvents: Acetic Acid,Water
标题:Oxidation Of Some Substituted Benzhydrols By Tl(Iii). A Kinetic Study
作者:Hiran,B. L.; Malkani,R. K.; Nalwaya,N.; Chand,K.; Rathore,N.
参考文献:Oxidation Communications 日期:2004 卷标:27(1) 页码:98-104]

1679-18-1 = 90-98-2
反应条件:1.1 Reagents: Sodium Carbonate Catalysts: Palladium Diacetate,1-[[[2-[(Aminoiminomethyl)Amino]Ethyl]Amino]Carbonyl]-1′-(Diphenylphosphino)Ferr... Solvents: Toluene,Water; 1 H,50 °C
标题:Synthesis Of Phosphanylferrocenecarboxamides Bearing Guanidinium Substituents And Their Application In The Palladium-Catalyzed Cross-Coupling Of Boronic Acids With Acyl Chlorides
作者:Charvatova,Hana; Cisarova,Ivana; Stepnicka,Petr
参考文献:European Journal Of Inorganic Chemistry 日期:2017 卷标:2017(2) 页码:288-296]

1714-50-7 = 90-98-2
反应条件:1.1 Reagents: Oxygen Catalysts: Diphenyl Ditelluride Solvents: Ethyl Acetate; 24 H
标题:Organotellurium-Catalyzed Oxidative Deoximation Reactions Using Visible-Light As The Precise Driving Energy
作者:Deng,Xin; Qian,Rongrong; Zhou,Hongwei; Yu,Lei
参考文献:Chinese Chemical Letters 日期:2021 卷标:32(3) 页码:1029-1032]

= 90-98-2
反应条件:1.1 Catalysts: Aluminum Chloride Solvents: 1,2-Dichloroethane; 30 Min,35 °C; 2 H,40 °C; 3 H,50 °C; 2 H,55 °C1.2 Reagents: Hydrochloric Acid Solvents: Water
标题:Synthetic Study On Polythioether Ketone Monomer 4,4'-Dichlorobenzophenone And 4-Chloro-4'-Fluorobenzophenone
作者:Xie,Yan; Zheng,Tucai; Gong,Xiaojuan; Lin,Feifei
参考文献:Huagong Xinxing Cailiao 日期:2012 卷标:40(2) 页码:87-90]

150766-93-1 = 90-98-2
反应条件:1.1 4.5 H,Rt
标题:Synthesis Of Symmetrical Diaryl Ketones By Cobalt-Catalyzed Reaction Of Arylzinc Reagents With Ethyl Chloroformate
作者:Rerat,Alice; Michon,Christophe; Agbossou-Niedercorn,Francine; Gosmini,Corinne
参考文献:European Journal Of Organic Chemistry 日期:2016 卷标:2016(26) 页码:4554-4560]

90-97-1 = 90-98-2
反应条件:1.1 Reagents: N-Bromosuccinimide,Alumina; 10 Min,Rt; 6 Min,Heated
标题:Microwave-Assisted Solvent-Free Oxidation Of Hydrobenzoins,Benzoins,And Alcohols With Nbs-Al2O3
作者:Khurana,Jitender M.; Arora,Reema
参考文献:Arkivoc (Gainesville 日期:2008 卷标:(14) 页码:211-215]

90-97-1 = 90-98-2
反应条件:1.1 Reagents: Tert-Butyl Hydroperoxide,4-Methylpyridine Catalysts: Chlorophyllin,Copper Sodium Complex Solvents: Acetone,Water; 10 H,80 °C1.2 Reagents: Sodium Thiosulfate Solvents: Water
标题:Sodium Copper Chlorophyllin Catalyzed Chemoselective Oxidation Of Benzylic Alcohols And Diarylmethanes In Water
作者:Liu,Shi-Juan; Zhang,Miao; Lu,Rong; Li,Xiu-Ying; Che,Guang-Bo
参考文献:Molecules 日期:2018 卷标:23(8) 页码:1883/1-1883/7]

5463-11-6 = 90-98-2
反应条件:1.1 Reagents: Sodium Bromate Catalysts: 1-Butyl-3-Methylimidazolium Hydrogen Sulfate Solvents: Water; 15 Min,60 °C; 60 °C -> Rt1.2 Reagents: Sodium Thiosulfate Solvents: Water
标题:A Simple,Mild And Environmentally Benign Procedure For The Cleavage Of Carbon-Nitrogen Double Bonds Using Nabro3 In The Presence Of [bmim]Hso4
作者:Lumb,Anshika; Rajeswari,M.; Khurana,Jitender M.
参考文献:Rsc Advances 日期:2014 卷标:4(88) 页码:47677-47689]

90-97-1 = 90-98-2
反应条件:1.1 Reagents: Chromium Trioxide; 0.5 Min,Rt
标题:Rapid Oxidation Of Alcohols To Aldehydes And Ketones With Chromium Trioxide Catalyzed By Kieselguhr Under Solvent-Free Conditions
作者:He,Ai; Zhang,Jie; Zheng,Wenjin; Huang,Chen; Zhang,Changhe; Et Al
参考文献:Research On Chemical Intermediates 日期:2013 卷标:39(3) 页码:1015-1020]

1714-50-7 = 90-98-2
反应条件:1.1 Catalysts: Manganese Oxide (Mno2); 2 Min,Rt
标题:A Simple,Rapid,And Efficient Oxidation Of Oximes To Ketones And Aldehydes With Manganese Dioxide Catalyzed By Kieselguhr Under Solvent-Free Conditions
作者:Zheng,Wenjin; Huang,Chen; Zhang,Changhe; Zhou,Yi-Feng; Lou,Ji-Dong
参考文献:Research On Chemical Intermediates 日期:2013 卷标:39(2) 页码:499-504]

101-76-8 = 90-98-2
反应条件:1.1 Reagents: Water Catalysts: Palladium Solvents: Dimethylacetamide; 48 H,130 °C
标题:Selective Oxidation Of Alkylarenes To The Aromatic Ketones Or Benzaldehydes With Water
作者:Zhang,Jin; Du,Jihong; Zhang,Chenyang; Liu,Kun; Yu,Feifei; Et Al
参考文献:Organic Letters 日期:2022 卷标:24(5) 页码:1152-1157]

2642-81-1 = 90-98-2
反应条件:1.1 Reagents: Potassium Sulfide,Oxygen Catalysts: Iron Chloride (Fecl3) Solvents: Dimethylformamide; 14 H,1 Atm,80 °C
标题:Fe-S Catalyst Generated In Situ From Fe(Iii)- And S3.--Promoted Aerobic Oxidation Of Terminal Alkenes
作者:Ai,Jing-Jing; Liu,Bei-Bei; Li,Jian; Wang,Fei; Huang,Cheng-Mi; Et Al
参考文献:Organic Letters 日期:2021 卷标:23(12) 页码:4705-4709]

1714-50-7 = 90-98-2
反应条件:1.1 Reagents: Oxygen Catalysts: Sodium Nitrite,Graphene Solvents: Acetonitrile; 120 Min,40 °C
标题:A Deoximation Method For Deprotection Of Ketones And Aldehydes Using A Graphene-Oxide-Based Co-Catalysts System
作者:Tong,Qiaolin; Liu,Yang; Gao,Xuezhi; Fan,Zhanfang; Liu,Tianfu; Et Al
参考文献:Advanced Synthesis & Catalysis 日期:2019 卷标:361(13) 页码:3137-3145]

83-05-6 = 90-98-2
反应条件:1.1 Reagents: Oxygen,Mercury Fluoride (Hgf2) Solvents: Acetonitrile; 24 H,25 °C
标题:Photolytic Decarboxylation Of α-Aryl Carboxylic Acids Mediated By Hgf2 Under A Dioxygen Atmosphere
作者:Farhadi,Saeid; Zaringhadam,Parisa; Sahamieh,Reza Zarei
参考文献:Tetrahedron Letters 日期:2006 卷标:47(12) 页码:1965-1968

1,4-二氯二苯甲基-1,2,4-噻唑置于lithium Diisopropyl Amide,碘体系中,用四氢呋喃,正己烷作为反应溶剂,化学反应 6.0H,反应生成 4,4'-二氯二苯甲酮
参考文献:Novel Heterocyclic Analogs Of Trityl Radicals: Synthesis And Dimerization Of Diarylmethyl-1H-1,2,4-Triazoles And Diarylmethyl-2H-Phenanthro[9,10-D]-1,2,3-Triazoles
标题:Novel Heterocyclic Analogs Of Trityl Radicals: Synthesis And Dimerization Of Diarylmethyl-1H-1,2,4-Triazoles And Diarylmethyl-2H-Phenanthro[9,10-D]-1,2,3-Triazoles
摘要:
DOI:10.3987/com-99-S9

海关参考信息

2903919090-氯苯
2912110000-甲醛
2912210000-苯甲醛
2903991000-对氯甲苯
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-11008273-B2
优先权日:2019-02-15
标题 :Process for the manufacture of fluorinated benzenes and fluorinated benzophenones, and derivatives thereof
发明人：ZHOU CHANGYUE; DU HONGJUN; WU WENTING
权利人:FUJIAN YONGJING TECH CO LTD
摘要:The invention relates to a new process for the manufacture or synthesis, respectively, of fluorinated benzenes and fluorinated benzophenones, and derivatives thereof, in particular of fluorobenzenes and derivatives thereof. The present invention particularly pertains to a novel environmentally friendly process for the synthesis of fluorinated benzenes and benzophenones as raw materials for the manufacture of polyaryletherketones (PAEKs).

专利号:US-4453012-A
优先权日:1982-04-22
标题 :Process for the preparation of phenyl ketones
发明人：DESBOIS MICHEL
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the preparation of phenyl ketones, characterized in that, in a first stage, a halo- or trihalomethylbenzene is reacted with a trihalomethylated aliphatic or aromatic compound in the presence of boron trifluoride in an amount such that the absolute pressure of boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent, and in that, in a second stage, the resultant product is hydrolyzed. The products are used as intermediates in the synthesis of compounds having a pharmaceutical or phytosanitary (e.g., herbicidal) activity.

专利号:US-8981036-B2
优先权日:2012-08-02
标题:Synthesis of and curing additives for phthalonitriles
发明人：KELLER TEDDY M; LASKOSKI MATTHEW
权利人:KELLER TEDDY M; LASKOSKI MATTHEW; US NAVY
摘要:A composition having a mixture of the below compounds having a mole ratio of at least 1:20. Ar 1 and Ar 2 are independently selected aromatic groups. A composition comprising phthalonitrile compounds that comprise at least 5 mol % of the first compound below. n nA method of: providing a solution of a dichloroaromatic compound having an electron-withdrawing group bound to each aromatic ring containing one of the chloride groups; a dihydroxyaromatic compound or anion thereof; an organic transition metal complex or a transition metal salt; an alkaline hydroxide base; and a solvent; and heating the solution to a temperature at which the dichloroaromatic compound and the dihydroxyaromatic compound react to form a dimetallic salt of an aromatic ether oligomer. The molar ratio of the dihydroxyaromatic compound to the dichloroaromatic compound is greater than 2:1. Water formed during the heating is concurrently distilled from the solution.

专利号:US-3869456-A
优先权日:1972-03-13
标题 :Synthesis of 5-pyrimidinecarbinols
发明人：TAYLOR HAROLD M; DAVENPORT JAMES D; HACKLER RONALD E
权利人:LILLY CO ELI
摘要:There is disclosed an improved method of synthesizing 5pyrimidinecarbinols by the addition of an alkyllithium to a mixture of 5-halopyrimidine and a ketone at a low temperature. The product compounds are useful as plant fungicides and as plant growth regulators.

专利号:US-8071788-B2
优先权日:2004-10-14
标题:Method and intermediates for the preparation of derivatives of N-(1-benzhydrylazetidin-3-yl)-N-phenylmethylsulfonamide
发明人：BOFFELLI PHILIPPE; DELTHIL MICHEL; GRONDARD LUC; LAMPILAS MAXIME; MALPART JOEL; MUTTI STEPHANE; NAIT-BOUDA LAHLOU; REIKE-ZAPP JOERG
权利人:BOFFELLI PHILIPPE; DELTHIL MICHEL; GRONDARD LUC; LAMPILAS MAXIME; MALPART JOEL; MUTTI STEPHANE; NAIT-BOUDA LAHLOU; REIKE-ZAPP JOERG; SANOFI AVENTIS
摘要:The invention relates to a novel method for the synthesis of N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5 -difluorophenyl)methylsulfonamide.

专利号:US-9085692-B1
优先权日:2014-02-25
标题 :Synthesis of oligomeric divinyldialkylsilane containing compositions
发明人：LASKOSKI MATTHEW; KELLER TEDDY M; SAAB ANDREW
权利人:LASKOSKI MATTHEW; KELLER TEDDY M; SAAB ANDREW; US GOVERNMENT
摘要:A method of: providing a solution of: a dichloroaromatic compound having an electron-withdrawing group bound to each aromatic ring containing one of the chloride groups; an excess of a dihydroxyaromatic compound; a base; and a solvent; heating the solution to a temperature at which the dichloroaromatic compound and the dihydroxyaromatic compound react to form an aromatic ether oligomer; and reacting the aromatic ether oligomer with a chlorodialkylvinylsilane to form one or more vinyl-terminated compounds having the formula below. The aromatic ether oligomer is a dihydroxy-terminated compound or a dimetallic salt thereof. Water formed during the heating is concurrently distilled from the solution. Each R is an alkyl group, Ar 1 is a residue from the dichloroaromatic compound, Ar 2 is a residue from the dihydroxyaromatic compound, and n is a non-negative integer.

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合成参考文献

摘要:Larsen, M. H.; Cacciarini, M.; Brøndsted Nielsen, M., Science of Synthesis Knowledge Updates, (2015) 2, 243.
摘要:Sellars, J. D., Science of Synthesis Knowledge Updates, (2014) 1, 435.
摘要:Sugamata, K.; Sasamori, T., Science of Synthesis Knowledge Updates, (2019) 2, 82.
摘要:Sellars, J. D., Science of Synthesis Knowledge Updates, (2014) 1, 403.
摘要:Vashchenko, B. V.; Grygorenko, O. O., Science of Synthesis Knowledge Updates, (2021) 3, 399.