CAS: 98349-22-5; 2,4,5-Trifluorobenzonitrile

上下游产品

CAS号327-52-6 2,4,5-三氟溴苯 | CAS号544-92-3 氰化亚铜 | CAS号446-17-3 2,4,5-三氟苯甲酸 | CAS号88419-56-1 2,4,5-三氟苯甲酰氯 | CAS号98349-24-7 2,4,5-三氟苯甲酰乙酸乙酯 | CAS号112279-61-5 4-氨基-2,5-二氟苯甲腈 | CAS号129946-63-0 2,5-二氟-4-肼基苯甲腈 | CAS号168644-93-7 2,4,5-三氟苄胺 | CAS号430459-44-2 bis(5-fluoro-2,... | CAS号390412-38-1 2,5-difluoro-4-...

2,4-二氯-5-氟苯腈置于potassium Fluoride,18-冠醚-6体系中,用 Neat (No Solvent) 作为反应溶剂,以92%的收率获得产物2,4,5-三氟苯腈
参考文献:一种含氟芳基化合物的制备方法
标题:一种含氟芳基化合物的制备方法
摘要:本发明涉及有机合成领域,特别是涉及一种含氟芳基化合物的制备方法.本发明提供一种式1化合物的制备方法,包括:氟化反应:将式2化合物在相转移催化剂存在的条件下与碱金属氟化物反应制备获得式1化合物.本发明所提供的含氟芳基化合物的制备方法,反应体系中不包括溶剂,且相转移催化剂沸点较高,反应结束后精馏或短蒸时无溶剂干扰,蒸馏收率高,产品纯度好.

专利信息

专利号:US-2025289827-A1
优先权日:2022-12-02
标 题:Morphic forms of a mutant braf degrader and methods of manufacture thereof
发明人：YU ROBERT T; HE MINSHENG; SCHNADERBECK MATTHEW J; KREGER BRIDGET; POLLOCK ROY MACFARLANE; JIANG SIYI; LI MEIQI; CHEN BOLU; LU JIANNAN
权利人:C4 THERAPEUTICS INC
摘要:Advantageous isolated morphic forms of (3R)-3-[6-[2-cyano-3-[[ethyl(methyl)sulfamoyl]amino]-6-fluorophenoxy]-4-oxoquinazolin-3-yl]-8-[2-[1-[3-(2,4-dioxo-1,3-diazinan-1-yl)-5-fluoro-1-methylindazol-6-yl]-4-hydroxypiperidin-4-yl]acetyl]-1-oxa-8-azaspiro[4.5]decane (Compound 1), which is a mutant BRAF degrader, and methods to prepare Compound 1 morphic forms for therapeutic applications are provided in the invention. The invention also provides improved methods for the synthesis of Compound 1, new pharmaceutical compositions comprising Compound 1, and new uses of Compound 1.

专利号:US-7642356-B2
优先权日:2005-09-16
标 题 :Process for preparing beta-ketoester compounds
发明人：SHIN HYUN IK; CHOI BO SEUNG; LEE JAE HOON
权利人:LG LIFE SCIENCES LTD
摘要:The present invention relates to a process for preparing a beta-keto ester compound of formula (1), which is an intermediate for the synthesis of quinolone antibiotics. Particularly, the present invention is characterized by the reaction of an organo nitrile compound with a salt of mono-alkyl malonate in the presence of metal salt, and so the reaction is easy to control due to its endothermic nature, and is devoid of lachrymatory reagents with excellent reproducibility. Subsequent in situ hydrolysis in the presence of aqueous acid solution provided the compound of formula (1).

专利号:US-6987199-B2
优先权日:2001-10-15
标题 :Process for preparing beta-ketoester compound
发明人：SHIN HYUN-LK; CHOI BO-SEUNG; CHOI SANG-CHUL
权利人:LG LIFE SCIENCES LTD
摘要:The present invention relates to a new process for preparing beta-ketoester compound of the following formula (1), which is a useful intermediate for the synthesis of such quinoline antibiotics as Ciprofloxacin, Levofloxacin, Gemifloxacin, Trovafloxacin, etc. The quinoline antibiotics obtained from the above compound of formula (1) show potent antibacterial activity, and so are advantageously used as a therapeutic agent for bacterial infections of humans or animals.

专利号:US-6090805-A
优先权日:1997-06-18
标 题 :Tocolytic oxytocin receptor antagonists
发明人：WILLIAMS PETER D; SPARKS MICHELLE A; BELL IAN; PERLOW DEBRA S; STAUFFER KENNETH; FREIDINGER ROGER M
权利人:MERCK & CO INC
摘要:This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.

专利号:CN-117466729-A
优先权日:2023-12-28
标题:A kind of synthesis method of 2,4,5-trifluorophenylacetic acid

专利号:CN-117486706-A
优先权日:2024-01-02
标题:A kind of synthesis method of 2,4,5-trifluorophenylacetic acid