CAS: 105931-73-5; 4-Bromo-2-Fluoro-1-Iodobenzene

上下游产品

CAS号14791-78-7 2-氟苯-1,4-二胺 | CAS号41604-19-7 4-溴-2-氟联苯 | CAS号513068-89-8 4-(2-氟-4-溴苯基)吗啉 | CAS号26608-06-0 3-溴二苯并呋喃 | CAS号574755-17-2 4-bromo-2-fluor... | CAS号606143-89-9 贝美替尼 | CAS号627463-17-6 4-BROMO-2-FLUOR...

专利信息

专利号:US-5254776-A
优先权日:1992-07-17
标 题:Synthesis of bromobiphenyls
发明人：LANG JOHN F; GURUSAMY NARAYANASAMY
权利人:MALLINCKRODT SPEC CHEM
摘要:Bromobiphenyls (such as 2-fluoro-4-bromobiphenyl) are synthesized by reacting together a phenylboronic acid (such as phenylboronic acid) and a bromoiodobenzene (such as 2-fluoro-4-bromoiodobenzene). The reaction generally takes place with the aid of a catalyst (such as palladium in a zero valance state) and an inert solvent (such as fluorobenzene). Control of temperature is very important to obtain both an acceptable reaction rate and an acceptable level of terphenyl byproduct.

专利号:US-8350100-B2
优先权日:2002-03-15
标题 :Process for the preparation of ring compounds
发明人：PAULUTH DETLEF; KIRSCH PEER; BAEUERLE PETER; DEEG OLIVER
权利人:MERCK PATENT GMBH; PAULUTH DETLEF; KIRSCH PEER; BAEUERLE PETER; DEEG OLIVER
摘要:In a process for the preparation of ring compounds via a combinatorial synthesis, the reaction procedure is based on a Suzuki coupling; subsequent halo-demetallation and finally a further Suzuki coupling. The Suzuki couplings are each carried out with a boronic acid or a boronic acid ester. The reaction procedure uses provides novel ring compounds and uses novel synthesis units used for this purpose. The novel ring compounds are suitable for use as constituents in liquid-crystalline mixtures.

专利号:US-9751874-B2
优先权日:2014-12-17
标题:Hydroxy containing FXR (NR1H4) modulating compounds
发明人：GEGE CHRISTIAN; KINZEL OLAF; KREMOSER CLAUS; SCHMITT AARON C
权利人:GILEAD SCIENCES INC
摘要:The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

专利号:CN-104087308-A
优先权日:2014-07-21
标 题 :A kind of trifluoromethoxy terminal substituted diaryl acetylene liquid crystal compound and its synthesis method