CAS: 1067-74-9; Methyl 2-(Diethoxyphosphoryl)Acetate

相似化合物

3095-95-2 867-13-0 867-13-0

上下游产品

sodium diethyl phosphite methyl chloroacetate methanol (Diethoxyphosphinyl)ketenmonoethylphosphonoacetic acid E)-3-methyl-hex-2-enoic acid methyl ester(E)-3-methyl-hex-2-enoic acid methyl ester cis-Methyl-3-methylhex-2-enoat 3-Methyl-5-phenyl-pent-2-ensaeuremethylester

二乙基膦酰基乙酸叔丁酯置于五氯化磷,三乙胺体系中,用 乙醚 用作溶剂,化学反应生成膦酰基乙酸甲酯二乙酯
参考文献:Bodnarchuk,N.D. Et Al.,Journal Of General Chemistry Of The Ussr,1971,Vol. 41,P. 1470-1473
标题:Bodnarchuk,N.D. Et Al.,Journal Of General Chemistry Of The Ussr,1971,Vol. 41,P. 1470-1473

专利信息

专利号:US-5808120-A
优先权日:1995-08-22
标 题 :Method of synthesis of retinoic acid
发明人：DELUCA HECTOR F; TADIKONDA PRAVEEN K
权利人:WISCONSIN ALUMNI RES FOUND
摘要:A method of synthesizing 9-cis-retinoic acid, all-trans-retinoic acid or 9-nor-retinoic acid is disclosed. The method comprises the steps of adding a Grignard reagent of ##STR1## to 2,2,6 trimethyl cyclohexanone is disclosed. R is a methyl group or H and the CH 2 --OH group is in either the cis or trans orientation relative to the HC.tbd.C- group. The resulting product is converted into retinoic acid. In the preferable form of the present invention, a tritium-labelled retinoic acid is synthesized, wherein the labelling is at the C 20 position. A preparation of tritium-labelled 9-cis-retinoic acid with a specific activity of greater than 65 Ci/mmol is also enclosed. In a most preferred embodiment, the specific activity is greater than 75 Ci/mmol.

专利号:US-3801607-A
优先权日:1971-03-11
标题:Derivatives of dinorcholestane and process
发明人：GOFFINET B
权利人:ROUSSEL UCLAF
摘要:A PROCESS FOR THE PREPARATION OF LOWR ALKYL ESTERS OF 26,27-DINORCHLOESTEN-25-OIC ACIDS OF THE FORMULA I 7,8-A,20-(R-OOC-(CH2)3-)PREGN-5-EN-3-OL WHEREIN R IS LOWER ALKYL AND A IS TWO HYDROGENS OR A DOUBLE BOND AND INTERMEDIATES SO PRODUCED. THE COMPOUNDS OF THE FORMULA I ARE INTERMEDIATES IN THE SYNTHESIS OF 25-HYDROXY CHLOESTEROL AND 25-HYDROXY-7(8)DEHYDRO-CHOLESTEROL. THESE LATTER COMPOUNDS ARE THEMSELVES INTERMEDIATES IN THE PREPARATION OF 25-HYDROXYCHOLECALCIFEROL WHICH POSSESSES AN IMPORTANT ANTI-RACHITIC PROPERTY, SUPERIOR TO THAT OF CHOLECALCIFEROL OR VITAMIN D3,

专利号:US-9260428-B2
优先权日:2007-03-22
标 题 :Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds
发明人：MERGELSBERG INGRID; SCHERER DOMINIK HERMANN; HUTTENLOCH MONIKA ERIKA; TSUI HON-CHUNG; PALIWAL SUNIL; SHIH NENG-YANG
权利人:OPKO HEALTH INC
摘要:This application discloses a process to synthesize 8-({1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy)-methyl]-8-pheny-1.7-diaza-spiro[4.5]decan-2-one comprising reacting a compound of the Formula 27a-sulfonate with zinc in the presence of acetic acid.

专利号:US-8003801-B2
优先权日:2005-11-22
标题:Chemical synthesis of a highly potent epothilone
发明人：NICOLAOU KYRIACOS C; PRATT BENJAMIN; ARSENIYADIS STELLIOS
权利人:SCRIPPS RESEARCH INST
摘要:A highly active synthetic epothilone compound whose activity exceeds that of either epothilone EpoA or EpoB when assayed as a cytotoxic agent against a cancer cell line is disclosed as is a pharmaceutical composition containing the synthetic epothilone.

专利号:US-6667406-B1
优先权日:1999-03-10
标题 :Methods for the synthesis of complex reduced isoindole, isooxyindole and isooxyquinoline libraries
发明人：SUN SENGEN; MURRAY WILLIAM V
权利人:ORTHO MCNEIL PHARM INC
摘要:Disclosed are methods of synthesizing libraries of diverse complex hexahydroisoindole, hexahydroisooxyindole and octahydroisooxyquinoline compounds through the use of a facile intramolecular Diels Alder reaction. The invention is further directed to methods for synthesizing the libraries on solid supports. The invention is further directed to methods for identifying and isolating such hexahydroisoindole, hexahydroisooxyindole and octahydroisooxyquinoline compounds with useful and diverse activities from such libraries.

专利号:US-4564477-A
优先权日:1982-02-19
标题 :Polyprenyl compounds and method of producing the same
发明人：TAKIGAWA TETSUO; IBATA KOICHI; OKADA MASAFUMI; MIZUNO MASAO; NISHIDA TAKASHI
权利人:KURARAY CO
摘要:There are provided polyprenyl compounds of the formula ##STR1## wherein ##STR2## represent a trans-isoprene unit and a cis-isoprene unit, respectively, n is an integer of 11-19, Z 1 and Z 2 combinedly represent â•?O, â•?CH--COOH,â•?CH--COOR 1 , â•?CH--CN, â•?C(CN)COOR 2 , â•?CH--CO--NH 2 , â•?CH--CO--N(R 3 ) (R 4 ), â•?CH--CO--NHR 5 , â•?CH--CH 2 --N(R 3 ) (R 4 ), â•?CH--CH 2 --NHR 5 or â•?CH--CHO or Z 1 is a hydrogen atom and Z 2 is --CH 2 COOH, --CH 2 COOR 6 , --CH(CN)COOR 2 , --CH 2 CN, --CH 2 --CO--NH 2 , --CHâ•?CH--N(R 3 ) (R 4 ) or --CH 2 --CHâ•?N--R 5 , R 1 , R 2 and R 6 each being a lower alkyl group, R 3 and R 4 each independently being a lower-alkyl, cycloalkyl, aryl or aralkyl group or R 3 and R 4 combinedly representing an alkylene group containing 2-5 carbon atoms, and R 5 being a lower-alkyl, cycloalkyl, aryl or aralkyl group. These polyprenyl compounds can be synthesized starting with a polyprenol obtainable from leaves of a plant such as Ginkgo biloba or Cedrus deodara by extraction and as necessary followed by hydrolysis, or a reactive derivative thereof. The polyprenyl compounds are useful as intermediates for the synthesis of dolichol without the ue of an expensive C 5 chain extender.