CAS: 146939-27-7; 2H-Indol-2-One, 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-Piperazinyl]Ethyl]-6-Chloro-1,3-Dihydro-

上下游产品

5-(2-(4-(7-bromo-1,2-benzisothiazol-3-yl)piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one 3-(1-piperazinyl)-1,2-benzisothiazole 6-chloro-5-(2-chloroethyl)-2-oxindole methyl 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-4-chloro-2-nitrophenyl acetateZiprasidone sulfoxide 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]-ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one hydrobromide monohydrate

5-(2-(4-(7-Bromo-1,2-Benzisothiazol-3-yl)Piperazinyl)-Ethyl)-6-Chloro-1,3-Dihydro-2H-Indol-2-One置于pd-Baso4 氢气体系中,用 四氢呋喃 用作溶剂,化学反应 6.0H,反应生成齐拉西酮
参考文献:Synthesis Of 3H-And 14C-Labelled Cp-88,059: A Potent Atypical Antipsychotic Agent
标题:Synthesis Of 3H-And 14C-Labelled Cp-88,059: A Potent Atypical Antipsychotic Agent
摘要:本文介绍了 3H 和 14C 标记的 Cp-88,059 [即 5-(2-(4-(1,2-苯并异噻唑-3-基)哌嗪基)乙基)-6-氯-1,3-二氢-2H-吲哚-2-酮] 的合成.Cp-88,059 (5B)是一种 D2/5-Ht2 联合拮抗剂,目前正在作为一种抗精神病药物进行临床评估,这种药物诱发精神分裂症患者 Eps 的可能性较低.通过氚气还原脱氢和 Pd/baso4 催化,将溴从苯并异噻唑分子的 7 位置换出来,得到了 3H-Cp-88,059 (5C).通过[2-14C]-氯乙酰氯对 6-氯氧化吲哚进行弗里德尔-卡夫酰化,然后用三乙基硅烷还原芳基羰基,并在回流的 Na2Co3 水溶液中与 N-(1,2-苯并异噻唑-3-基)哌嗪偶联,实现了 14C 与分子乙烯部分的结合.
Doi:10.1002/jlcr.2580340203

专利信息

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:US-2003083352-A1
优先权日:2000-07-31
标 题 :Synthesis of imidazole intermediates
发明人：HELAL CHRISTOPHER J
权利人:PFIZER
摘要:The invention provides a method for synthesis of compounds of formula n n n wherein R 1 and R 19 are as defined. Compounds of formula 12 are useful as intermediates for synthesizing compounds having pharmacological activity inhibiting cdk5, cdk2, and GSK-3.

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-9315483-B2
优先权日:2007-09-13
标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
发明人：JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT
权利人:CONCERT PHARMACEUTICALS INC
摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.

专利号:US-12006301-B1
优先权日:2021-05-13
标题 :And synthesis of dual 5-HT1A and 5-HT7 receptor ligands
发明人：ABLORDEPPEY SETH Y
权利人:FLORIDA A&M UNIV
摘要:Novel dual 5-HT1A and 5-HT7 receptor ligands and methods of using the novel ligands to treat a neurological disorder are presented.

专利号:US-2011040105-A1
优先权日:2008-04-16
标题 :Processes useful for the synthesis of (r)-1--2-methyl-pyrrolidine
发明人：HUBER CHRISTIAN H; KHULMAN YOUNG MI; TANDEL SAGUN K; JOHANNSEN STEPHEN R; WANG TINGMIN; ANGELL PAUL
权利人:ARENA PHARM INC
摘要:Processes useful for making a pharmaceutically useful compound according to Formula (I), forms of such a compound, and intermediates useful in such processes are described.