CAS: 185847-84-1; Benzyl 4-Oxo-3,4-Dihydropyridine-1(2H)-Carboxylate

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CAS号620-08-6 4-甲氧基吡啶 | CAS号501-53-1 氯甲酸苄酯 | CAS号53708-19-3 4-异丙氧基吡啶 | CAS号19099-93-5 1-Cbz-4-哌啶酮 | CAS号24681-60-5 2,3-dihydro-1H-... | CAS号952183-52-7 1-CBZ-2-异丙基-4-哌啶酮 | CAS号849928-35-4 1-Cbz-2-苄基-4-哌啶酮 | CAS号849928-34-3 1-CBZ-2-甲基-4-哌啶酮 | CAS号335266-05-2 1-Cbz-2-苯基-4-哌啶酮 | CAS号68471-58-9 1-Cbz-3,4-二氢-2H-吡啶 | CAS号865996-16-3 Benzyl 5-bromo-...

Benzyl 6-Bromo-1,4-Dioxa-8-Azaspiro[4.5]Decane-8-Carboxylate置于1,8-二氮杂双环[5.4.0]十一碳-7-烯体系中,用 二甲基亚砜 用作溶剂,化学反应生成4-氧代-3,4-二氢吡啶-1(2H)-羧酸苄酯
参考文献: 5-(Arylsulfonyl)-Pyrazolopiperidines[fr] 5-(Arylsulfonyl)-Pyrazolopiperidines
标题: 5-(Arylsulfonyl)-Pyrazolopiperidines[fr] 5-(Arylsulfonyl)-Pyrazolopiperidines

专利信息

专利号:US-2025270185-A1
优先权日:2024-02-28
标题 :Method for preparation of iptacopan hydrochloride
发明人：ZHANG YIPING; LIU QIAOLING; WU YIHUA; ZHENG XUCHUN
权利人:HANGZHOU CHEMINSPIRE TECH CO LTD
摘要:A synthesis method for iptacopan is provided, which includes the asymmetric addition of compound 1 as the starting material with compound 2 benzyl 4-oxo-3,4-dihydropyridine-1(2H)-carboxylate under the action of a metal catalyst and ligand to obtain intermediate compound 3; then, carbonyl group being enzymatically reduced to obtain compound 4; compound 4 undergoing catalytic conversion from the cyano group to the carboxyl group under the action of a cyano hydrolysis enzyme in a one-pot reaction; subsequently, hydroxy groups completing the ethylation reaction; after palladium hydrogenation, key intermediate compound 6 of iptacopan being obtained; finally, compounds 6 and 7 undergoing reduction amination condensation, followed by removing the Boc group to form the target product: hydrochloride salt of iptacopan. This method features a simple process route, high yield, and low costs, which is suitable for industrial production.

专利号:CN-118126021-A
优先权日:2024-02-28
标 题 :A kind of synthesis method of ipracopan hydrochloride