CAS: 22094-18-4; 1,3-Dibromo-2,2-Dimethoxypropane

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126-38-5 7252-83-7 22089-54-9

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CAS号67-56-1 甲醇 | CAS号67-64-1 丙酮 | CAS号26562-24-3 2-甲氧基-3-溴丙烯 | CAS号816-39-7 1,3-二溴丙酮 | CAS号77-76-9 2,2-二甲氧基丙烷 | CAS号115118-67-7 diethyl 3,3-dim... | CAS号115118-69-9 ethyl 3,3-dimet... | CAS号133-13-1 乙基丙二酸二乙酯 | CAS号115118-68-8 3,3-二甲氧基环丁烷-1,1...

丙酮,原甲酸三甲酯置于溴体系中,用 甲醇 用作溶剂,以84%的收率获得1,3-二溴-2,2-二甲氧基丙烷
参考文献:一种麦角硫因关键中间体的制备方法
标题:一种麦角硫因关键中间体的制备方法
摘要:本发明公开了一种麦角硫因关键中间体的制备方法,属于药物合成技术领域.丙酮与原甲酸三甲酯,溴素反应得到1,3‑二溴‑2,2‑二甲氧基丙烷,随后与硫氰化钾,醋酸铵反应得到5‑溴甲基‑1H‑咪唑‑2‑硫醇,随后在无机碱条件下与氯化苄或溴化苄反应得到产物2‑苄硫基‑5‑溴甲基‑1H‑咪唑.本发明工艺操作简便稳定,产率高,环境友好,降低了现有麦角硫因中间体的生产成本,有利于工业化规模生产.

专利信息

专利号:WO-2022170218-A1
优先权日:2021-02-05
标题:Intramolecular cyclization for general synthesis of bicyclic alkyl bioisostere boronates
发明人：QIN TIAN; YANG YANGYANG; TSIEN JET
权利人:UNIV TEXAS
摘要:Disclosed herein are methods of synthesizing compounds of the formula (I) wherein the variables are defined herein. Also provided are compounds produced using these methods. In some aspects, the methods provided herein may be used to install aryl bioisosteres.

专利号:WO-2024064745-A1
优先权日:2022-09-21
标 题:Synthesis of reldesemtiv
发明人：PETERSON MATTHEW W; LU QING; MORGAN BRADLEY P; ASHCRAFT LUKE W; ANDERSEN DENISE
权利人:CYTOKINETICS INC
摘要:Provided herein is a process for the preparation of reldesemtiv and salts thereof. Also provided herein are intermediates used in this process and their preparation.

专利号:WO-2024052739-A1
优先权日:2022-09-08
标 题 :Method for the synthesis of benzodioxepinone compounds and intermediates thereof
发明人：NANDAN DR SANTOSH RAGHU; KORI AMITKUMAR RAMBIHARI; SHARMA BASANTKUMAR RAJKUMAR; SATISH SOHAL; CHITRAL ROHAN KAILASH; S JAYASHREE PUTTUR
权利人:AMBERNATH ORGANICS PVT LTD
摘要:A method for the preparation of benzodioxepinone compounds of formula (I), and the intermediates thereof, wherein, R 1 is independently selected from the group consisting of hydrogen, halogen, C 1 -C 6 alkyl, C 2 - C 6 alkenyl and C 3 -C 6 cycloalkyl; n represents integer 0-3.

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

专利号:CN-107739328-A
优先权日:2017-11-22
标 题 :The preparation method of the key intermediate 1 for the synthesis of baricitinib

专利号:US-7179794-B2
优先权日:1998-06-08
标题 :Multivalent macrolide antibiotics
发明人：GRIFFIN JOHN H; PACE JOHN L
权利人:THERAVANCE INC
摘要:Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more proteins involved in ribosomal protein synthesis in the bacterium, which are useful in treating bacterial infections. The compounds adversely affect protein expression and have an antibacterial effect. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is macrolide antibiotic, aminoglycoside, lincosamide, oxazolidinone, streptogramin, tetracycline or other compound which binds to bacterial ribosomal RNA and/or one or more proteins involved in ribosomal protein synthesis in the bacterium.