专利号:US-6756199-B1 优先权日:1994-02-23 标题:Peptide nucleic acid combinatorial libraries and improved methods of synthesis 发明人:COOK PHILLIP DAN; KIELY JOHN; SPRANKLE KELLY 权利人:ISIS PHARMACEUTICALS INC 摘要:New sub-monomer synthetic methods for the preparation of peptide nucleic acid oligomeric structures are disclosed that provide for the synthesis of both predefined sequence peptide nucleic acid oligomers as well as random sequence peptide nucleic acid oligomers. Further these methods also provide for the incorporation of peptide nucleic acid units or strings of such units with amino acids or strings of amino acids in chimeric peptide nucleic acid-amino acid compounds. Further disclosed are method of making random libraries of peptide nucleic acids using the fully preformed monomers. Chimeric oligomers and libraries of the same are also disclosed.
专利号:US-9796688-B2 优先权日:2004-08-20 标 题:Catalysis of diketopiperazine synthesis 发明人:STEVENSON JOHN J; MOYE-SHERMAN DESTARDI 权利人:MANNKIND CORP 摘要:Provided is a method for the synthesis of N-protected bis-3,6-[4-aminobutyl]-2,5-diketopiperazine including the step of heating a solution of ε-amino protected lysine in the presence of a catalyst selected from the group consisting of sulfuric acid, phosphoric acid, and phosphorus pentoxide.
专利号:CN-107513145-A 优先权日:2017-08-23 标题:Synthesis of Biodegradable Amphiphilic Block Copolymerized Antimicrobial Peptides and Preparation and Application of Antimicrobial Peptide Vesicles
专利号:US-4960881-A 优先权日:1984-02-16 标 题 :α-chlorinated carbonates, their method of manufacture and application in the protection of the amine functions of amino acids 发明人:BARCELO GERARD; SENET JEAN-PIERRE; SENNYEY GERARD 权利人:POUDRES & EXPLOSIFS STE NALE 摘要:The invention relates to carbonates of formula: ##STR1## in which X is a fluorine, chlorine or bromine atom and R 1 is different from the ##STR2## group and represents: a substituted or non-substituted, saturated or unsaturated, aliphatic, araliphatic, primary, secondary, tertiary or cycloaliphatic radical. These α-chlorinated carbonates are prepared by the action of a compound of formula R 1 OH on a chloroformate of formula: ##STR3## in a solvent medium in the presence of an acid scavenger which is added after the two preceding compounds. They are used to block the amine function of amino acids. The α-chlorinated carbonate and amino acid are reacted in a solvent medium at a temperature of -5° to 100° C. in the presence of an acid scavenger. Blocked amines are very useful in peptide synthesis.
专利号:US-4038282-A 优先权日:1975-11-26 标 题 :Pyridyl-4-methyl-succinimidocarbonate and process for its preparation 发明人:HIRSCHMANN RALPH F; VEBER DANIEL F 权利人:MERCK & CO INC 摘要:The disclosed invention relates to ε-N-pyridyl-4-methyloxycarbonyllysine valuable in the synthesis of lysine containing peptides to the process of preparing this compound starting with 4-pyridyl-carbinol and succinimido-chloroformate and to the pyridyl-4-methyl-succinimidocarbonate intermediate in this process.
专利号:US-4006152-A 优先权日:1971-12-30 标题:ε-N-pyridyl-4-methyloxycarbonyllysine 发明人:VEBER DANIEL F; HIRSCHMANN RALPH F 权利人:MERCK & CO INC 摘要:The disclosed invention relates to epsilon -N-pyridyl-4-methyloxycarbonyllysine valuable in the synthesis of lysine containing peptides to the process of preparing this compound starting with 4-pyridylcarbinol and succinimido-chloroformate and to the pyridyl-4-methyl-succinimidocarbonate intermediate in this process.
[参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. [参考文献]: A S Bajkowski, Et Al. The Ph Dependency Of Bovine Spleen Cathepsin B-Catalyzed Transfer Of N Alpha-Benzyloxycarbonyl-L-Lysine From P-Nitrophenol To Water And Dipeptide Nucleophiles. Comparisons With Papain. J Biol Chem. 1983 Feb 10;258(3):1650-5. [参考文献]: Kimiyasu Isobe, Et Al. Characterization Of Nalpha-Benzyloxycarbonyl-L-Lysine Oxidizing Enzyme From Rhodococcus Sp. Aiu Z-35-1. J Biosci Bioeng. 2007 Sep;104(3):218-23. [参考文献]: Rong Kuang, Et Al. Nanofibrous Spongy Microspheres Enhance Odontogenic Differentiation Of Human Dental Pulp Stem Cells. Adv Healthc Mater. 2015 Sep 16;4(13):1993-2000.
合成参考文献
参考文献:10.1134/s0006297911040122 摘要:Mikhailova AG, Khairullin RF, Demidyuk IV, Gromova TY, Kostrov SV, Rumsh LD. Oligopeptidase B from Serratia proteamaculans. II. Enzymatic characteristics: substrate analysis, influence of calcium ions, pH and temperature dependences. Biochemistry (Mosc). 2011 Apr;76(4):480–90. doi: 10.1134/s0006297911040122.