CAS: 40246-10-4; 3-(4-Hydroxyphenyl)-6-Methoxy-7-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-4H-Chromen-4-One

该化合物是自然产生的一种主要存在于大豆和其他豆类中的亚拉松胶胶质; 它是谷素分子附着于该分子的异质素甘斯坦的衍生物, 提高了其溶解性和生物利用率; Glycitin 表现出抗氧化剂的特性, 有助于其潜在的健康惠益, 包括抗炎效应和荷尔蒙调节中可能发挥的作用; 作为植物质, 它可以在体内模仿雌激素, 这可能影响到更年期症状和骨骼健康; Glycitin 经常被研究其在不同健康状况中的潜在治疗用途, 包括癌症和心血管疾病; 就物理特性而言, 甘油通常是白色的白粉, 溶解于水中, 稳定在正常的储存条件下. 其安全性简介一般被认为是有利的, 尽管正在进行进一步的研究, 以充分了解其生物效果和行动机制.

结构式图片

上下游产品

CAS号1105697-69-5 4'-O-hexanoylgl... | CAS号40957-83-3 黄豆黄素 | CAS号50-99-7 D(+)-无水葡萄糖 | CAS号7298-22-8 1-[5-Methoxy-2,... | CAS号58115-19-8 3,3-Dimethoxy-1... | CAS号58115-20-1 1-(2,4-Dihydrox... | CAS号40957-83-3 黄豆黄素

合成工艺路线路线简述

  • 合成目标产物 Glycitin 主要起始原料 Uridine 5'-(Trihydrogen Diphosphate), Mono-Alpha-D-Glucopyranosyl Ester And Glycitein
  • (文献来源)合成步骤主要原料 Uridine 5'-(Trihydrogen Diphosphate), Mono-Alpha-D-Glucopyranosyl Ester 和 Glycitein
黄豆黄素置于吡啶,Sodium Methylate,Silver(L) Oxide体系中,化学反应 3.08H,反应生成 黄豆黄苷
参考文献:Nogradi,Mihaly; Szoellosy,Aron,Liebigs Annalen,1996,# 10,P. 1651-1652
标题:Nogradi,Mihaly; Szoellosy,Aron,Liebigs Annalen,1996,# 10,P. 1651-1652

海关参考信息

专利信息


专利号:US-7598291-B2
优先权日:2004-09-02
标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin
发明人:NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:US-2010160244-A1
优先权日:2004-09-02
标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin
发明人:NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:US-6849701-B2
优先权日:2001-03-02
标 题:Droplet polymerization method for synthesis of molecularly imprinted polymers
发明人:NORTON TUCKER
权利人:DU PONT
摘要:A droplet polymerization process is provided to create efficacious molecularly imprinted polymers (MIPs). Such imprinted polymers have increased surface area for adsorptive or catalytic reactions. This method provides for monomer-template interactions in the absence of a suspending medium, thereby permitting formation of MIPs with increased template selectivity and substantial processing advantages. The process is particularly useful for separating isoflavones from soy whey.

专利号:US-7202398-B2
优先权日:2002-08-16
标 题 :Chalcone isomerase
发明人:MCGONIGLE BRIAN
权利人:DU PONT
摘要:An isolated nucleic acid fragment encoding a chalcone isomerase is disclosed. Also of concern is the synthesis of a recombinant DNA construct encoding all or a portion of the chalcone isomerase, in sense or antisense orientation, wherein expression of the recombinant DNA construct results in production of altered levels of the chalcone isomerase in a transformed host cell.

专利号:US-2002198349-A1
优先权日:2001-03-02
标 题:Droplet polymerization method for synthesis of molecularly imprinted polymers

专利号:CN-104761627-A
优先权日:2015-04-20
标 题:Application of GmbHLH Transcription Factor in Promoting the Synthesis of Soybean Isoflavones
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主要参考文献


1: Kim YM, Huh JS, Lim Y, Cho M. Soy Isoflavone Glycitin (4'-Hydroxy-6-Methoxyisoflavone-7-D-Glucoside) Promotes Human Dermal Fibroblast Cell Proliferation and Migration via TGF-β Signaling. Phytother Res. 2015 May;29(5):757-69. doi: 10.1002/ptr.5313. Epub 2015 Mar 11. doi: 10.1080/09168451.2014.955453. Epub 2014 Sep 11. Epub 2016 Sep 13.
5: Li XH, Zhang JC, Sui SF, Yang MS. Effect of daidzin, genistin, and glycitin on osteogenic and adipogenic differentiation of bone marrow stromal cells and adipocytic transdifferentiation of osteoblasts. Acta Pharmacol Sin. 2005 Sep;26(9):1081-6. doi: 10.1021/jf204432g. Epub 2012 Feb 1. doi: 10.1093/chromsci/bmu045. Epub 2014 May 28. doi: 10.3109/09637486.2016.1144724. Epub 2016 Feb 16. doi: 10.1038/emm.2016.167.
11: van der Velpen V, Geelen A, Hollman PC, Schouten EG, van 't Veer P, Afman LA. Isoflavone supplement composition and equol producer status affect gene expression in adipose tissue: a double-blind, randomized, placebo-controlled crossover trial in postmenopausal women. Am J Clin Nutr. 2014 Nov;100(5):1269-77. doi: 10.3945/ajcn.114.088484. Epub 2014 Aug 20. doi: 10.3109/09637486.2015.1095861. Epub 2015 Oct 12. doi: 10.1111/1750-3841.13236. Epub 2016 Jan 27. doi: 10.3797/scipharm.1410-02. Print 2015 Apr-Jun.

合成参考文献


参考文献:10.3109/09637486.2015.1095861
摘要:Baú TR, Garcia S, Ida EI. Changes in soymilk during fermentation with kefir culture: oligosaccharides hydrolysis and isoflavone aglycone production. International Journal of Food Sciences and Nutrition. 2015 Oct 12;66(8):845–50. doi: 10.3109/09637486.2015.1095861.
参考文献:10.1007/bf02976633
摘要:Park KY, Jung GO, Choi J, Lee KT, Park HJ. Potent antimutagenic and their anti-lipid peroxidative effect of kaikasaponin III and tectorigenin from the flower of Pueraria thunbergiana. Arch Pharm Res. 2002 Jun;25(3):320–4. doi: 10.1007/bf02976633.
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