欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
benzaldehyde propan-1-ol-3-amine benzylamine N-Benzyliden-3-hydroxy-1-propanamin4-benzyl-tetrahydro-[1,4]oxazepin-3-one 3-(N-benzyl-N-methylamino)-propan-1-ol methanol N-benzyl-2-oxazolidinone 合成工艺路线路线简述
- 合成目标产物 N-Benzyl-3-Aminopropan-1-Ol 主要起始原料 Benzaldehyde And 3-Aminopropanol
- (文献来源)合成步骤主要原料 Benzaldehyde 和 3-Aminopropanol
Diethyl N-Benzylphosphoramidate置于盐酸,Sodium Hydroxide,双氧水,Sodium Hydride,9-硼双环[3.3.1]壬烷体系中,用 水 作为反应溶剂,化学反应 18.0H,反应生成 N-苄基-3-氨基丙醇
参考文献:Benmaarouf-Khallaayoun,Z.; Baboulene,M.; Speziale,V.,Synthetic Communications,1985,Vol. 15,# 3,P. 233-242
标题:Benmaarouf-Khallaayoun,Z.; Baboulene,M.; Speziale,V.,Synthetic Communications,1985,Vol. 15,# 3,P. 233-242
专利信息
专利号:US-7816375-B2
优先权日:2000-09-11
标 题 :Ligands for monoamine receptors and transporters, and methods of use thereof
发明人:AQUILA BRIAN M; BANNISTER THOMAS D; CUNY GREGORY D; HAUSKE JAMES R; HOLLAND JOANNE M; PERSONS PAUL E; RADEKE HEIKE; WANG FENGJIANG; SHAO LIMING
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.
专利号:US-2017119786-A1
优先权日:2011-03-08
标 题 :Heterocyclic modulators of lipid synthesis
专利号:US-6613942-B1
优先权日:1997-07-01
标题 :Glucagon antagonists/inverse agonists
发明人:LING ANTHONY; GREGOR VLAD; GONZALEZ JAVIER; HONG YUFENG; KIEL DAN; KUKI ATSUO; SHI SHENGHUA; NAERUM LARS; MADSEN PETER; SAMS CHRISTIAN; LAU JESPER; PLEWE MICHAEL BRUNO; FENG JUN; TENG MIN; JOHNSON MICHAEL DAVID; TESTON KIMBERLY ANN; SIDELMANN ULLA GROVE; KNUDSEN LOTTE BJERRE
权利人:NOVO NORDISK AS
摘要:Non-peptide compounds comprising a central hydrazide motif and methods for the synthesis thereof are disclosed. The compounds act to antagonize the action of the glucagon peptide hormone.