合成目标产物 4-Phenoxyphenylboronic Acid 主要起始原料 Triisopropyl Borate And Bis(4-Bromophenyl) Ether And Water
(文献来源)合成步骤主要原料 Triisopropyl Borate 和 Bis(4-Bromophenyl) Ether 和 Water
二苯醚置于盐酸,N-溴代丁二酰亚胺(Nbs),正丁基锂体系中,用 四氢呋喃,二氯甲烷,水 作为反应溶剂,化学反应生成 4-苯氧基苯基硼酸 参考文献:Platinum(II) Cyclometallates Featuring Broad Emission Bands And Their Applications In Color-Tunable Oleds And High Color-Rendering Woleds 标题:Platinum(II) Cyclometallates Featuring Broad Emission Bands And Their Applications In Color-Tunable Oleds And High Color-Rendering Woleds 摘要:两种含有灵活的苯氧基团的新的磷光铂(II)环金属配合物已经制备完成,在固态中具有宽广的激聚发射态,可用于制备高色彩还原性的双发射体woleds. DOI:10.1039/c6Tc01594H
专利号:WO-2025101716-A1 优先权日:2023-11-07 标题:Processes for synthesis of trifunctionalized sulfur(vi) compounds 发明人:LOPCHUK JUSTIN; SHULTZ ZACHARY; ATHAWALE PARESH 权利人:H LEE MOFFITT CANCER CT & RES 摘要:This disclosure describes processes for the asymmetric synthesis of trifunctionalized sulfur(VI) containing organic compounds of Formula I and Formula VI, as well as compounds of Formula I and Formula VI prepared by the processes described.
专利号:WO-2020117135-A1 优先权日:2018-12-04 标 题:A process for preparation of 1h-pyrazolo[3,4-d] pyrimidine derivatives 发明人:HAAS PHILIPP DANIEL; STECKEL ANDREAS HARTWIG; BELLUR ATICI ESEN; ALTUNDAS RAMAZAN; OZTURK AYDIN BUSRA; SECEN HASAN; AYDIN BUSRA NUR 权利人:DEVA HOLDING AS 摘要:The present invention relates to an efficient and industrially advantageous process for the preparation of 1H-pyrazolo[3,4-d] pyrimidine derivatives. In particular the present invention provides a process for the preparation of 4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4- d]pyrimidine and tert-butyl (R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4- d]pyrimidin-1-yl)piperidine-1-carboxylate. Said compounds are important intermediates in the synthesis of ibrutinib. The method provided for preparing intermediates of ibrutinib has the advantages of a simple operation, high yield and low costs.
专利号:US-2025101021-A1 优先权日:2022-06-14 标 题:Methods of making tolebrutinib 发明人:BAILLY FRÉDÉRIC; BENELLI CHRISTOPHE; BORIE CYRIL; BOSCH MICHAËL; CABOS CLAUDE; CHARAUDEAU ALEXIS; JANSSENS LAURENCE; PACQUET FRANÇOIS; RODIER FABIEN; SALLÉ LAURENT; SODO ALFRED; VIGNE SYLVIE 权利人:PRINCIPIA BIOPHARMA INC 摘要:Disclosed herein are improved synthetic routes for making (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1 H-imidazo[4,5-c]pyridin-2(3H)-one (tolebrutinbib). Also disclosed herein are novel compounds used in the synthesis of of (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1 H-imidazo[4,5-c]pyridin-2(3H)-one.
专利号:US-7115737-B2 优先权日:2003-05-05 标题:Solid phase synthesis of novel biaryl triazine library by suzuki cross coupling 发明人:CHANG YOUNG-TAE 权利人:UNIV NEW YORK 摘要:Two methods are used to produce diaryl trisubstituted triazines. In the first method, cyanuric chloride is first reacted with a 4-alkoxybenzylamine. The product of this reaction is then reacted with a resin-bound amine, such as 4-alkoxybenzylamine, to ensure that the final compound will be bound to a resin. The product of this reaction is then reacted with boronic acid to produce a trisubstituted diaryl triazine. In the second method, cyanuric chloride is reacted with a benzenealkanethiol. The product of this reaction is then reacted with a resin-bound amine, such as 4-alkoxybenzylamine, to ensure that the final compound will be bound to a resin. The product of this reaction is then reacted with m-CPBA to form a sulfone, which is then reacted with a 4-alkoxybenzylamine to form the desired trisubstituted biaryltriazine.
专利号:US-2018222909-A1 优先权日:2015-07-29 标 题 :Process for the preparation of ibrutinib and new synthesis intermediate 发明人:BERTOLINI GIORGIO; FERRANDO ILARIA; SADA MARA 权利人:OLON SPA 摘要:Subject-matter of the invention is a process for the preparation of ibrutinib and intermediate compound.
专利号:US-2004225125-A1 优先权日:2003-05-05 标 题 :Solid phase synthesis of novel biaryl triazine library by suzuki cross coupling