CAS: 535-80-8; 3-Chlorobenzoic Acid

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CAS号35190-17-1 3,3-二氯苯偶姻 | CAS号108-41-8 间氯甲苯 | CAS号67-56-1 甲醇 | CAS号108-37-2 1-溴-3-氯苯 | CAS号201230-82-2 carbon monoxide | CAS号2905-65-9 间氯苯甲酸甲酯 | CAS号541-73-1 间二氯苯 | CAS号937-14-4 间氯过氧苯甲酸 | CAS号456-39-3 3-氯重氮苯四氟硼酸盐 | CAS号2516-95-2 5-氯-2-硝基苯甲酸 | CAS号4771-47-5 3-氯-2-硝基苯甲酸 | CAS号3739-38-6 3-苯氧基苯甲酸 | CAS号321-14-2 5-氯代水杨酸 | CAS号1829-32-9 3-氯水扬酸 | CAS号34662-36-7 3-氯-5-硝基苯甲酸 | CAS号34841-39-9 安非他酮 | CAS号34841-35-5 间氯苯丙酮 | CAS号92264-81-8 羟基安非他酮 | CAS号1074-36-8 4-巯基苯甲酸

3-氯苯甲酸乙酯置于水,Lithium Hydroxide体系中,用 四氢呋喃 作为反应溶剂,化学反应 6.0H,以100%的收率获得产物3-氯苯甲酸
参考文献:锂阳离子在四氢呋喃水溶液中酯类水解反应中的效率
标题:锂阳离子在四氢呋喃水溶液中酯类水解反应中的效率
摘要:在水/四氢呋喃 (Thf) 两相系统中,观测到锂阳离子可加速酯类与氢氧化物(koh,Naoh,Lioh)的水解.比较了使用各种氢氧化物水解取代苯甲酸酯和脂肪族酯的产率,并检查了添加锂盐的影响.此外,推测一定量的lioh通过thf与锂阳离子的配位和水解酯甚至在thf层中溶解在thf中,如在相转移催化剂的反应中. 全尺寸图像
DOI:10.1248/cpb.C21-00013

专利信息

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-9388131-B2
优先权日:2011-04-27
标题:Automated synthesis of small molecules using chiral, non-racemic boronates
发明人：BURKE MARTIN D; LI JUNQI; GILLIS ERIC P
权利人:UNIV ILLINOIS
摘要:Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.

专利号:US-5442065-A
优先权日:1993-09-09
标 题:Synthesis of tetrahydroquinoline enediyne core analogs of dynemicin
发明人：MAGNUS PHILIP D; ILIADIS THEODORE; EISENBEIS SHANE A; FAIRHURST ROBIN A
权利人:UNIV TEXAS
摘要:A process is described for the preparation of the core azobicyclo[7.3.1]tridecaenediyne moiety of the antitumor antibiotic dynemicin. The synthesis allows efficient production of the enediyne as a stable, compound in good yield from the adamantyl N-protected azabicyclo[7.3.1]tridecadiyne. The adamantyl protecting group is employed in the starting material, N-adamantyl dihydroquinoline or N-adamantyl 6-methoxy quinoline. Also disclosed are process for the synthesis of 3-hydroxy-6-methoxyquinoline and several N-substituted derivatives of azobicyclo[7.3.1]tridecaenediyne. Solid tumor and leukemia assays were performed on the analogs of dynemicin. The results suggest a method that these compounds will useful in treating certain types of leukemias and solid tumors. The disclosed synthesis provides a route to new dynemicin intermediates and analogs which will allow development of second and third generation dynemicins.

专利号:US-9233943-B2
优先权日:2012-01-10
标题:Process for synthesis of syn azido epdxide and its use as intermediate for the synthesis of amprenavir and saquinavir
发明人：GADAKH SUNITA KHANDERAO; REKULA REDDY SANTHOSH; SUDALAI ARUMUGAM
权利人:COUNCIL SCIENT IND RES
摘要:A novel synthetic route to the syn-azido epoxide of formula 5 includes cobalt-catalyzed hydrolytic kinetic resolution of a racemic mixture of the azido-epoxide. Reaction steps include subjecting an allylic alcohol to epoxidation with mCPBA to obtain a racemic epoxy alcohol; ring opening the epoxy alcohol with azide anion to obtain an anti-azido alcohol, which can then be selectively tosylated at the primary alcohol; treating the tosylate with base to obtain the racemic azido-epoxide; and subjecting the racemic azido-epoxide to cobalt-catalyzed hydrolytic kinetic resolution to obtain the syn-azido epoxide of formula 5. The compound of formula 5 may be used as a common intermediate for the asymmetric synthesis of HIV protease inhibitors, such as Amprenavir, Fosamprenavir, Saquinavir, and formal synthesis of Darunavir and Palinavir.

专利号:US-5145957-A
优先权日:1988-03-18
标 题:Stereoselective synthesis of a chiral cis 3-beta hydrogen (3R) 4-aroyloxy azetidinone
发明人：TSCHAEN DAVID M; LYNCH JOSEPH E; LASWELL WILLIAM L; VOLANTE RALPH P; SHINKAI ICHIRO
权利人:MERCK & CO INC
摘要:A process is described for the stereocontrolled synthesis of (3R,4R)-3-[(1R)-1-hydroxyethyl]-4-benzoyloxyazetidin-2-ones and their derivatives by cycloaddition involving an imine and a ketone, generated from 3(S)-hydroxybutyrate which are useful intermediates in the synthesis of carbapenem antibiotics.

专利号:WO-2013018053-A1
优先权日:2011-08-02
标题 :Process for the preparation of epoxides as intermediates for the synthesis of nebivolol
发明人：CIPOLLONE AMALIA; D ANDREA PIERO; FATTORI DANIELA
权利人:MENARINI INT OPERATIONS LU SA; CIPOLLONE AMALIA; D ANDREA PIERO; FATTORI DANIELA
摘要:The present invention relates to a novel process of synthesis of epoxides, 6-fluoro-2- (oxiran-2-yl) chroman (Figure 1), intermediates for the synthesis of nebivolol, depicted in Scheme (1), enabling to obtain the above- mentioned epoxides in a racemic or semichiral form.