CAS: 54301-15-4; N-(4-(Acridin-9-Ylamino)-3-Methoxyphenyl)Methanesulfonamide Hydrochloride

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CAS号1207-69-8 9-氯吖啶 | CAS号57165-06-7 N-(4-氨基-3-甲氧基苯基)甲磺酰胺 | CAS号57165-05-6 3-methoxy-4-nit... | CAS号16292-88-9 3-甲氧基-4-硝基苯胺 | CAS号20628-19-7 N-(3-甲氧基-4-硝基苯基)乙酰胺

3-甲氧基-4-硝基苯胺置于palladium On Activated Charcoal 吡啶,盐酸,氢气体系中,用 甲醇 作为反应溶剂,20.0 °C,202.65 Kpa 条件下,反应 4.25H,反应生成 胺苯吖啶
参考文献:Potential Antitumor Agents. 48. 3'-Dimethylamino Derivatives Of Amsacrine: Redox Chemistry And In Vivo Solid Tumor Activity
标题:Potential Antitumor Agents. 48. 3'-Dimethylamino Derivatives Of Amsacrine: Redox Chemistry And In Vivo Solid Tumor Activity
摘要:Structure-Activity Relationships For A Series Of Acridine-Substituted 3'-N(Ch3)2 Derivatives Of The Clinical Antileukemic Drug Amsacrine (1) Are Reported. The Parent (Unsubstituted) Compound 3 Has Activity Against The Lewis Lung Solid Tumor That Is Superior To Amsacrine (1),The New Clinical Amsacrine Analogue 4,And The Recently Developed 3'-Nhch3 Derivative 2. Although The Compounds Generally Bind Less Well To Dna And Are Less Dose Potent In Vivo Than Either Their Amsacrine (3'-och3) Or 3'-Nhch3 Analogues,They Show Very High Levels Of Antitumor Activity,With The 4-och3 Derivative Capable Of Effecting 100% Cures Of The Lewis Lung Solid Tumor. The Broad Structure-Activity Relationships For Acridine Substitution More Closely Resemble Those Of The Amsacrine Than The 3'-Nhch3 Series,With 4-Substituted And 4,5-Disubstituted Compounds Showing The Highest Activity.
DOI:10.1021/jm00387A012