CAS: 552846-17-0; Tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)-1H-Pyrazole-1-Carboxylate

相似化合物

1188405-87-9 1301198-65-1 863238-73-7

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CAS号269410-08-4 4-吡唑硼酸频哪醇酯 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号25015-63-8 频那醇硼烷 | CAS号219580-32-2 1H-吡唑-1-羧酸叔丁酯 | CAS号269410-08-4 4-吡唑硼酸频哪醇酯

4-吡唑硼酸频哪醇酯置于4-二甲氨基吡啶体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 1-Boc-吡唑-4-硼酸频哪醇酯
参考文献:Therapeutically Active Compounds And Their Methods Of Use
标题:Therapeutically Active Compounds And Their Methods Of Use
摘要:提供的方法是治疗一种由idh1/2突变等位基因特征性存在的癌症,包括向需要此治疗的患者施用此处描述的化合物.

专利信息

专利号:US-7585875-B2
优先权日:2006-06-06
标 题 :Substituted pyrazolo[1,5-a]pyridine compounds and their methods of use
发明人：GAETA FEDERICO C A; GROSS MATTHEW; JOHNSON KIRK W
权利人:AVIGEN INC
摘要:The present invention is directed to substituted pyrazolo[1,5-a]pyridines and related methods for their synthesis and use.

专利号:US-2023025807-A1
优先权日:2019-10-30
标题:Cd38 inhibitors
发明人：KULKARNI SANTOSH S; LAGU BHARAT; WU XINYUAN
权利人:MITOBRIDGE INC
摘要:The present invention is directed to a compound of Formula (I) or a pharmaceutically acceptable salt thereof. Compounds of Formula (I) are CD38 inhibitors, which can be used to treat a disease or condition in a subject that benefits from an increase in NAD + or to treat a mitochondrial disorder in a subject. Such disease or condition is a muscle structure disorder, a neuronal activation disorder, a muscle fatigue disorder, a muscle mass disorder, a metabolic disease, a cancer, a vascular disease, an ocular vascular disease, a muscular eye disease, or a renal disease. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 30 to 135; examples 1 to 61; table). Such an exemplary compound is e.g. N-((1r,4r)-4-(2-methoxyethoxy) cyclohexyl)-5-(thiazol-5-yl)-1H-indole-7-carboxamide (II).

专利号:US-8785632-B2
优先权日:2004-08-26
标 题:Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors
发明人：CUI JINGRONG JEAN; FUNK LEE ANDREW; JIA LEI; KUNG PEI-PEI; MENG JERRY JIALUN; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; SHEN HONG; TRAN-DUBE MICHELLE
权利人:CUI JINGRONG JEAN; FUNK LEE ANDREW; JIA LEI; KUNG PEI-PEI; MENG JERRY JIALUN; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; SHEN HONG; TRAN-DUBE MICHELLE; AGOURON PHARMA; PFIZER
摘要:Enantiomerically pure compound of formula 1 n nare provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

专利号:US-10227344-B2
优先权日:2016-06-24
标题 :CK2 inhibitors, compositions and methods thereof
发明人：WEBBER STEPHEN E; TAO XUELIANG; BRIN ELENA
权利人:POLARIS PHARMACEUTICALS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula (I), or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. n nFor Formula (I) compounds R 1 , R 2 , R 3 , Ar and Z are as defined in the specification. The inventive Formula (I) compounds are inhibitors of CK2 and find utility in any number of therapeutic applications, including but not limited to treatment of proliferative disorders such as cancer, inflammation and immunological disorders.

专利号:US-2007275968-A1
优先权日:2004-09-07
标 题 :Substituted Biphenyl Derivative
发明人：KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
权利人:KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
摘要:The present invention relates to a biaryl derivative or a pharmacologically acceptable salt thereof having an excellent collagen-synthesis inhibition activity. A biaryl derivative having a structure represented by the following General Formula (I) or a pharmacologically acceptable salt thereof: n nwherein n R 1 represents a C 6 -C 10 aryl group which is substituted with one to three group(s) each independently selected from the group consisting of a group defined by formula R-L-, a di-(C 1 -C 6 alkyl)amino group, a di-(C 1 -C 6 alkyl)aminosulfonyl group, a hydroxyaminocarbonyl group, and a halogen atom, and so on; R represents a C 1 -C 6 alkyl group, and so on; L represents a sulfonyl group, an aminosulfonyl group, or a sulfonylamino group, and so on; R 2 represents a hydrogen atom, and so on; A represents a group defined by formula (II), (III), or (IV); R 3 represents a C 1 -C 6 alkyl group, and so on; and R 4 represents a C 1 -C 6 alkyl group, and so on.

专利号:US-8633204-B2
优先权日:2006-09-15
标 题 :4-methylpyridopyrimidinone compounds
发明人：CHENG HENGMIAO; BHUMRALKAR DILIP; DRESS KLAUS RUPRECHT; HOFFMAN JACQUI ELIZABETH; JOHNSON MARY CATHERINE; KANIA ROBERT STEVEN; LE PHUONG THI QUY; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; PLEWE MICHAEL BRUNO; TRAN KHANH TUAN
权利人:CHENG HENGMIAO; BHUMRALKAR DILIP; DRESS KLAUS RUPRECHT; HOFFMAN JACQUI ELIZABETH; JOHNSON MARY CATHERINE; KANIA ROBERT STEVEN; LE PHUONG THI QUY; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; PLEWE MICHAEL BRUNO; TRAN KHANH TUAN; PFIZER
摘要:The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), n nand to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-Kα).