专利号:US-3772389-A 优先权日:1971-06-24 标 题:Process for the synthesis of phenyl esters 发明人:LOWRANCE W 权利人:EASTMAN KODAK CO 摘要:A PROCESS FOR THE SYNTHESIS OF PHENYL ESTERS DIRECTLY FROM THE CORRESPONDING PHENOLS AND CARBOXYLIC ACIDS WHICH COMPRISES CONTACTING A PHENOLIC COMPOUND HAVING AT LEAST ONE HYDROGEN ATOM ADJACENT THE ACTIVE HYDROXYL GROUP WITH A CARBOXYLIC ACID COMPOUND CONTAINING AT LEAST ONE ACTIVE CARBOXYLIC GROUP IN THE PRESENCE OF A CATALYTIC AMOUNT OF A BORATE-SULFURIC ACID CATALYST COMPLEX. THE PROCESS IS CARRIED OUT IN A SINGLE STAGE REACTOR WHICH MAY BE OPERATED AT FROM 75*C. TO 285*C. UNDER ATMOSPHERIC, SUBATMOSPHERIC OR SUPERATMOSPHERIC PRESSURE. IF DESIRABLE, A SOLVENT CAN BE EMPLOYED.
专利号:WO-9845231-A1 优先权日:1997-04-09 标题:Supports for solid phase synthesis 发明人:SHAO HUI; CASTELHANO ARLINDO L 权利人:CADUS PHARMACEUTICAL CORP 摘要:Supports for solid-phase synthesis are disclosed. The supports include a phenol or thiophenol linker moiety. A substrate compound can be immobilized to the support through the linker moiety. The supports are suitable for combinatorial synthesis, including synthesis of combinatorial libraries.
专利号:US-4921997-A 优先权日:1988-06-15 标题 :Method of synthesis and novel compounds for pharmaceutical uses 发明人:LALEZARI IRAJ; LALEZARI PARVIZ 权利人:MONTEFIORE MED CENTER 摘要:The present invention is concerned with a process for the synthesis of substituted arylureidophenexymethyl propionic acids and an analogous benzamides series of compounds which have activity in the dissociation of oxygen from hemoglobin. In addition, the process may be utilized to prepare compounds which are known.
专利号:US-7253324-B1 优先权日:2007-01-23 标 题:Process for the synthesis of biologically active oxygenated compounds by dealkylation of the corresponding alkylethers 发明人:MAJEED MUHAMMED; THOMAS SAMUEL MANOHARAN; NAGABHUSHANAM KALYANAM; BALAKRISHNAN SIVAPRAKASH KURUM; PRAKASH SUBBALAKSHMI 权利人:SAMI LABS LTD 摘要:Alkoxy aromatic compounds are conveniently dealkylated to the corresponding phenolic compounds by treatment with aluminum chloride/N,N-dimethyl aniline complex. Aromatic poly O-demethylation is a unique feature of this invention. This process is applicable to the manufacture of polyphenols such as Resveratrol, Oxyresveratrol, Gnetol.
专利号:US-8703996-B2 优先权日:2010-03-09 标题:Short synthesis of tolterodin, intermediates and metabolites 发明人:STERK DAMJAN 权利人:STERK DAMJAN; LEK PHARMACEUTICALS 摘要:A process is described for the preparation of intermediates which can be used for preparation of agents for urinary incontinence therapy, specifically to 2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol and its prodrugs.
专利号:US-4822903-A 优先权日:1981-05-15 标题:Fluorinated silica catalyst and preparation of aromatic/aliphatic nitriles in the presence thereof 发明人:JACQUES ROLAND; REPPELIN MICHEL; SEIGNEURIN LAURENT 权利人:RHONE POULENC SPEC CHIM 摘要:An improved fluorinated siliceous catalyst, well adapted for the catalytic synthesis of aromatic/aliphatic nitriles from their corresponding formamides, formanilides or amides, is comprised of a plurality of silica particulates, the specific surface of which ranging from about 200 to about 300 m 2 /g, having a total pore volume ranging from about 1 to about 1.5 cm 3 /g, with an average pore diameter ranging from about 100 to about 200 â„«, having an exchange pH of less than about 3, and with the fluorine content thereof bonded to the silica, expressed in F 31 , ranging from about 0.05 to about 2% by weight based upon the silica, and the sodium content thereof, expressed as Na 2 O, being less than about 1% by weight, also based upon the silica.
摘要:Drabowicz, J.; Krasowska, D.; Wicha, J., Science of Synthesis, (2009) 48, 260. 摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 85. 摘要:Shimada, K., Science of Synthesis Knowledge Updates, (2010) 1, 419. 摘要:Aitken, R. A., Science of Synthesis Knowledge Updates, (2018) 3, 304. 摘要:Rudzinski, D. M.; Leadbeater, N. E., Science of Synthesis Knowledge Updates, (2012) 1, 384.