CAS: 104-82-5; 4-Methylbenzyl Chloride

上下游产品

CAS号589-18-4 4-甲基苄醇 | CAS号104-87-0 对甲基苯甲醛 | CAS号3395-83-3 p-(dimethoxymet... | CAS号50-00-0 甲醛 | CAS号108-88-3 甲苯 | CAS号622-47-9 对甲苯乙酸 | CAS号81067-95-0 4-Methyl-thiobe... | CAS号74260-32-5 (p-Me-benzyl)tr... | CAS号106-42-3 对二甲苯 | CAS号106670-34-2 2-[(4-甲基苄基)硫代]乙胺 | CAS号3762-25-2 4-甲基苄基磷酸二乙酯 | CAS号56442-19-4 4-[(4-甲基苄基)-氧基]苯羧酸 | CAS号52803-64-2 3-甲氧基-2-[(4-甲基苄... | CAS号356570-52-0 4-甲基苄基硼酸频哪醇酯 | CAS号4957-14-6 二对甲苯基甲烷 | CAS号21895-17-0 BENZENE,1-METHY... | CAS号18869-29-9 4,4-二甲基-反-二苯乙烯 | CAS号106-42-3 对二甲苯 | CAS号538-39-6 1,2-二对甲苯基乙烷

对甲基苯乙酸置于次氯酸叔丁酯,Silver Triflate-Bis(1,10-Phenanthroline) Complex体系中,用 乙腈 用作溶剂,化学反应 3.0H,以76%的收率获得4-甲基氯苄
参考文献:脂肪族羧酸的银催化脱羧氯化
标题:脂肪族羧酸的银催化脱羧氯化
摘要:羧酸的脱羧卤化反应(hunsdiecker 反应)是有机化学中基本的官能团转化之一.由于最初的方法需要制备严格无水的羧酸银,因此已进行了一些修改以简化程序.然而,这些方法存在使用剧毒试剂,反应条件苛刻或应用范围有限的问题.此外,对脂肪族羧酸没有催化作用.在本文中,我们报告了脂肪族羧酸的第一个催化 Hunsdiecker 反应.因此,在 Ag(Phen)(2)Otf 的催化下,羧酸与次氯酸叔丁酯的反应在温和条件下以高产率提供了相应的氯代脱羧产物.这种方法不仅高效通用,但也是化学选择性的.此外,它表现出显着的官能团相容性,使其在有机合成中具有更大的实用价值.提出了单电子转移继之以氯原子转移的机理用于催化氯代脱羧反应.
Doi:10.1021/ja210361Z

专利信息

专利号:US-6515039-B1
优先权日:1998-08-28
标 题:Method for the parallel and combinatory synthesis of compounds bound to a continuous polymeric solid phase supporting material
发明人：ULBRICHT MATHIAS; VOLKMER-ENGERT RUDOLF; GERMEROTH LOTHAR; WENSCHUH HOLGER
权利人:POLY AN GMBH
摘要:The invention relates to a method for the parallel and combinatory synthesis of compounds bound to a continuous polymeric solid phase supporting material. According to the method, a continuous polymeric solid phase supporting material is prepared, the material comprising a matrix of a supporting polymeric material and graft copolymer chains covalently bound to the supporting matrix, the graft copolymer chains having reactive groups being able to react with organic compounds, thereby forming spatially defined reaction sites. The method then comprises the sequential spotting of synthesis building blocks or reagents at the various reaction sites on the continuous solid phase supporting material to yield a substrate library of compounds bound to the solid phase supporting material, whereby each reaction site on the continuous solid phase supporting material determines the composition of the synthesized compound, which is bound directly on the supporting matrix via the reactive groups of the graft polymer chain.

专利号:US-9012625-B2
优先权日:2009-04-07
标 题 :Method for the synthesis of a trisaccharide
发明人：DÉKANY GYULA; Ã?GOSTON KÃ?ROLY; BAJZA ISTVAN; BOUTET JULIEN; BØJSTRUP MARIE; FANEFJORD METTE; PÉREZ FIGUEROA IGNACIO; HEDEROS MARKUS; HORVATH FERENC; KOVÃ?CS-PÉNZES PIROSKA; KRÖGER LARS; OLSSON JOHAN; RÖHRIG CHRISTOPH; SCHROVEN ANDREAS; VRASIDAS IOANNIS
权利人:DÉKANY GYULA; Ã?GOSTON KÃ?ROLY; BAJZA ISTVAN; BOUTET JULIEN; BØJSTRUP MARIE; FANEFJORD METTE; PÉREZ FIGUEROA IGNACIO; HEDEROS MARKUS; HORVATH FERENC; KOVÃ?CS-PÉNZES PIROSKA; KRÖGER LARS; OLSSON JOHAN; RÖHRIG CHRISTOPH; SCHROVEN ANDREAS; VRASIDAS IOANNIS; GLYCOM AS
摘要:The present invention relates to an improved synthesis of a trisaccharide of the formula (1), novel intermediates used in the synthesis and the preparation of the intermediates.

专利号:US-6723798-B1
优先权日:2000-08-28
标 题:Resins having vinyl ether linker for the solid phase organic synthesis
发明人：YOO SUNGEUN; GONG YOUNGDAE; SEO JINSOO
权利人:KOREAN RES INST OF CHEMICAL TE
摘要:The present invention relates to a resin having a vinyl ether linker and more particularly, to a resin having a vinyl ether linker expressed by formula (I), useful for the synthesis of compounds having hetero atoms such as alcohol, thiol, imidazole, triazole and tetrazole by employing combinatorial chemical synthesis on solid supports.

专利号:US-6133409-A
优先权日:1996-12-19
标 题:Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds
发明人：SALVINO JOSEPH M; MORTON GEORGE C; MASON HELEN J; LABAUDINIERE RICHARD F
权利人:AVENTIS PHARM PROD INC
摘要:This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and alpha , beta -unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.

专利号:EP-0791575-A1
优先权日:1996-02-16
标题 :Method of synthesis of a quaternary ammonium salt
发明人：NAKANO SHINJI
权利人:NIPPON PAINT CO LTD
摘要:The present invention provides an improved method of synthesis of a quaternary ammonium salt in which a tertiary amine is reacted with a benzyl halide optionally having on the benzene ring and/or at the α-site one ore more substituent groups inert to the reaction, which method is characterized in that the reaction is carried out in water or in a water-containing organic solvent.

专利号:US-2025236633-A1
优先权日:2022-03-28
标 题:Synthesis of isomerically pure polyol-based phosphoramidites
发明人：BANASIK BRENT; DIAZ CORRAL JULIAN ANDRES; JACOBS AARON; JUD LUKAS; KUCHELMEISTER HANNES; NBAVI MELUD; PFAFFENEDER TONI; SIMONYIOVA SONA; TABONE JOHN C; THUER WILMA
权利人:ROCHE SEQUENCING SOLUTIONS INC
摘要:The present disclosure relates to a process for the regiochemically and enantiomerically controlled synthesis of phosphoramidite-containing monomers, and to intermediate products of this process. In some embodiments, the phosphoramidite-containing monomers or their precursors are regioisomerically and/or enantiomerically pure and may be polymerized into polymers or copolymers.