CAS: 131747-62-1; 3-(Trifluoromethyl)Pyridine-2-Carboxaldehyde

相似化合物

87407-12-3 406933-21-9 588702-69-6

上下游产品

(3-(trifluoromethyl)pyridin-2-yl)methanol 2-chloro-3-trifluoromethyl-pyridine 3-Trifluoromethyl-2-picoline-N-oxide Acetic acid 3-trifluoromethyl-pyridin-2-ylmethyl ester 2-(N-Benzyl-N-methylamino)ethyl Methyl 4-(3-Trifluoromethyl-2-pyridyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate (3-bromo-phenyl)-(3-trifluoromethyl-pyridin-2-yl)-methanol 2-(5'-(5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl)benzimidazol-2'-yl)-3-trifluoromethylpyridine (S)-N-((S)-(4-methoxyphenyl)(3-(trifluoromethyl)pyridin-2-yl)methyl)-2-methylpropane-2-sulfinamide

2-氯-3-三氟甲基吡啶置于四(三苯基膦)钯 Sodium Hydroxide,磷酸,二甲基亚砜,间氯过氧苯甲酸,N,N'-二环己基碳二亚胺体系中,用 甲醇 用作溶剂,化学反应 3.0H,反应生成3-(三氟甲基)吡啶-2-甲醛
参考文献:新型1,4-二氢吡啶类钙拮抗剂.I.4-(取代的吡啶基)-1,4-二氢吡啶衍生物的合成和降血压活性.
标题:新型1,4-二氢吡啶类钙拮抗剂.I.4-(取代的吡啶基)-1,4-二氢吡啶衍生物的合成和降血压活性.
摘要:合成了一系列4-(取代的吡啶基)-1,4-二氢吡啶衍生物,并研究了它们的降压作用.几种化合物,2-(n-苄基-N-甲基氨基)乙基甲基1,4-二氢-2,6-二甲基-4-(3-硝基-2-吡啶基)-3,5-吡啶二甲酸(2B),4-(4-硝基-2-吡啶基)类似物(2G),4-(3-三氟甲基-2-吡啶基)类似物(2C),4-(2-三氟甲基-3-吡啶基)类似物(3E),4-发现(4-氰基-2-吡啶基)类似物(2E),4-(2-氰基-3-吡啶基)类似物(3D)和4-(6-溴-2-吡啶基)类似物(2I)具有与尼卡地平类似的降压活动;特别是2C和3E的持续时间约为尼卡地平的两倍,而2E具有在所有合成衍生物中最有效的降压活性.
Doi:10.1248/cpb.38.2446

专利信息

专利号:US-10759743-B2
优先权日:2016-10-24
标 题 :Pd-catalyzed γ-C(sp3)-H arylation / heteroarylation of free amines
发明人：YU JIN-QUAN
权利人:SCRIPPS RESEARCH INST
摘要:Pd(II)-catalyzed g-G(sp3)-H arylation or heteroarylation of primary amines is realized by using 2-hydroxynicotinaldehyde as a catalytic transient directing group. Importantly, the catalyst and the directing group loading can be lowered to 2% and 4% respectively, thus demonstrating high efficiency of this newly designed transient directing group. Heterocyclic aryl iodides are also compatible with this reaction. Furthermore, swift synthesis of 1,2,3,4-tetrahydronaphthyridine derivatives is accomplished using this reaction.

专利号:US-9446047-B2
优先权日:2013-09-10
标 题 :Substituted 2,3-dihydro-1H-inden-1-one retinoic acid-related orphan nuclear receptor antagonists for treating multiple sclerosis
发明人：VANKAYALAPATI HARIPRASAD; YERRAMREDDY VENKATAKRISHNAREDDY
权利人:ARRIEN PHARMACEUTICALS LLC
摘要:The present invention is directed to compounds, their synthesis, and their use as antagonists, inverse agonists, modulators and or inhibitors of the Retinoic acid-related orphan nuclear receptor γt (RORγt)/RORγ. The compounds of the present invention are useful for modulating RORγt)/RORγ activity and for treating diseases or conditions mediated by RORγt)/RORγ such as for example, disease states associated with immunopathology of human autoimmune diseases such as Multiple Sclerosis (MS), Rheumatoid Arthritis (RA), Inflammatory Colitis, Psoriasis, COPD, Pain, Obesity, Diabetes, Dyslipidemia, Osteoporosis, Asthma, Neurodegenerative diseases and Cancer.