CAS: 151266-23-8; 3-Iodo-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine

相似化合物

1513882-52-4 862729-12-2 2380-63-4

上下游产品

pyrimidin4-Aminopyrazolo3,4-dpyrimidin 4-aminopyrazolo[3,4-d]pyrimidine N-iodo-succinimide 4-chloro-1H-pyrazolo[3,4-d]pyrimidine pyrimidine4-amino-3-iodo-1-(2,3-di-O-benzoyl-5-deoxy-β-D-ribofuranosyl)pyrazolo3,4-dpyrimidine pyrimidine4-amino-3-iodo-1-(2,3-di-O-benzoyl-5-deoxy-5-chloro-β-D-ribofuranosyl)pyrazolo3,4-dpyrimidine pyrimidine4-amino-3-iodo-1-(2,3-di-O-benzoyl-5-deoxy-5-azido-β-D-ribofuranosyl)pyrazolo3,4-dpyrimidine 3-iodo-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

4-氨基吡唑并[3,4-D]嘧啶置于n-碘代丁二酰亚胺体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 1.0H,反应生成3-碘-4-氨基吡唑并[3,4-D]嘧啶
参考文献:一种荧光激酶抑制剂,在结合时表现出诊断性的变化.
标题:一种荧光激酶抑制剂,在结合时表现出诊断性的变化.
摘要:描述了在结合激酶后显示出有利的溶剂变色性质的荧光lck抑制剂的开发.荧光特性是通过在atp竞争性激酶抑制剂的药效基团中包含前生荧光团来实现的.荧光滴定实验证明了该抑制剂的溶剂变色性质,其中在结合lck时清楚地观测到发射强度的显着增加和发射最大值的变色移动.细胞环境中的显微镜实验以及流式细胞仪表明,抑制剂的荧光强度与lck浓度相关.此外,
Doi:10.1002/anie.201909536

专利信息

专利号:WO-2020117135-A1
优先权日:2018-12-04
标 题:A process for preparation of 1h-pyrazolo[3,4-d] pyrimidine derivatives
发明人：HAAS PHILIPP DANIEL; STECKEL ANDREAS HARTWIG; BELLUR ATICI ESEN; ALTUNDAS RAMAZAN; OZTURK AYDIN BUSRA; SECEN HASAN; AYDIN BUSRA NUR
权利人:DEVA HOLDING AS
摘要:The present invention relates to an efficient and industrially advantageous process for the preparation of 1H-pyrazolo[3,4-d] pyrimidine derivatives. In particular the present invention provides a process for the preparation of 4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4- d]pyrimidine and tert-butyl (R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4- d]pyrimidin-1-yl)piperidine-1-carboxylate. Said compounds are important intermediates in the synthesis of ibrutinib. The method provided for preparing intermediates of ibrutinib has the advantages of a simple operation, high yield and low costs.

专利号:AU-2022253019-A1
优先权日:2021-04-09
标题:Synthesis of rapamycin analog compounds

专利号:TW-202304863-A
优先权日:2021-04-09
标题:Synthesis of rapamycin analog compounds

专利号:WO-2022216900-A2
优先权日:2021-04-09
标题 :Synthesis of rapamycin analog compounds

专利号:US-2018222909-A1
优先权日:2015-07-29
标 题 :Process for the preparation of ibrutinib and new synthesis intermediate
发明人：BERTOLINI GIORGIO; FERRANDO ILARIA; SADA MARA
权利人:OLON SPA
摘要:Subject-matter of the invention is a process for the preparation of ibrutinib and intermediate compound.

专利号:US-2024174615-A1
优先权日:2021-04-09
标题:Synthesis of rapamycin analog compounds
发明人：BALLMER STEVEN G; HUANG XIAOJUN; LI SHAOLING
权利人:REVOLUTION MEDICINES INC
摘要:The present disclosure relates to novel methods for preparing rapamycin analog compounds, as well as to related intermediates useful in such methods.