CAS: 2052-01-9; 2-Bromo-2-Methylpropanoic Acid

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23426-63-3 23877-12-5 41658-69-9

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CAS号79-31-2 异丁酸 | CAS号19455-20-0 异丁酸钾 | CAS号20769-85-1 2-溴-2-甲基丙酰溴 | CAS号818-61-1 丙烯酸羟乙酯 | CAS号100-52-7 苯甲醛 | CAS号62-57-7 2-氨基异丁酸 | CAS号563-80-4 甲基异丙基甲酮 | CAS号7726-95-6 溴素 | CAS号943-45-3 2-甲基-2-苯氧基丙酸 | CAS号51368-55-9 2-溴代异丁酸异丙酯 | CAS号42017-89-0 非诺贝特酸 | CAS号220022-94-6 2-(二甲基氨基)-2-甲基丙酸 | CAS号18672-07-6 Ethyl 2-(4-cyan... | CAS号20469-89-0 2-溴异丁酰氯 | CAS号20940-21-0 2-(dimethylcarb... | CAS号79-41-4 甲基丙烯酸 | CAS号53498-62-7 2-甲基-2-(2-甲基苯氧基)丙酸 | CAS号15001-71-5 2-乙氧基-2-甲基丙酸

异丁酸置于n-溴代丁二酰亚胺(Nbs)体系中,用 四氯化碳 用作溶剂,化学反应 72.0H,反应生成2-溴-2-甲基丙酸
参考文献:固相肽合成新方法中的叠氮酸.
标题:固相肽合成新方法中的叠氮酸.
摘要:通过用nbs进行α-溴化,然后用叠氮化钠取代,由α-支链酸生产出叠氮酸,并将其用于新的固相合成方法.叠氮基酸被转化为高度活化的酰氯,并用于合成高度受阻的肽,该肽包含多达四个连续的二苯基甘氨酸或aib残基.通过遗传编码的氨基酸与tfn 3然后与socl 2的反应,它们被转化为用于固相肽合成的α-叠氮酰氯,而没有消旋作用.©1997爱思唯尔科学有限公司.
Doi:10.1016/s0040-4039(97)00393-6

专利信息

专利号:US-6162882-A
优先权日:1996-07-10
标 题:Preparation of novel homo- and copolymers using atom transfer radical polymerization
发明人：MATYJASZEWSKI KRZYSZTOF; COCA SIMION; GAYNOR SCOTT G; NAKAGAWA YOSHIKI; JO SEONG MU
权利人:UNIV CARNEGIE MELLON
摘要:The present invention is directed to a process of atom (or group) transfer radical polymerization for the synthesis of novel homopolymer or a block or graft copolymer, optionally containing at least one polar group, with well defined molecular architecture and narrow polydipersity index, in the presence of an initiating system comprising (i) an initiator having a radically transferrable atom or group, (ii) a transition metal compound, and (iii) a ligand, the present invention is also directed to the synthesis of a macromolecule having at least two halogen groups which can be used as a macroinitiator component (i) to subsequently form a block or graft copolymer by an atom or group transfer radical polymerization process; the present invention is also directed to a process of atom or group transfer radical polymerization for the synthesis of a branched or hyperbranched polymer; in addition, the present invention is directed to a process of atom or group transfer radical polymerization for the synthesis of a macroinitiator which can subsequently be used to produce a block or graft copolymer.

专利号:US-2013165350-A1
优先权日:2011-12-22
标 题:Surface linkers for array synthesis
发明人：KUIMELIS ROBERT; MCGALL GLENN; PAO DEXTER; CHEN ZIHUI; AXELROD TREVOR
权利人:KUIMELIS ROBERT; MCGALL GLENN; PAO DEXTER; CHEN ZIHUI; AXELROD TREVOR; AFFYMETRIX INC
摘要:The present invention provide several methods of derivatizing a surface of a support with one or more linkers thus providing a suitable platform for synthesis of a polymer array, particular a nucleic acid array. Some methods derivatize a surface with a self-assembled monolayer (SAM) of a linker. The SAM confers advantages of hydrolytic stability, broad compatibility with synthesis and detection chemistries, and reduced emergence of latent functional groups during polymer array synthesis. Substrates can also be derivatized with multi-layers of SAMs providing greater hydrolytic stability. Substrates can also be derivatized by synthesizing a linker in situ on the substrate by atom transfer radical polymerization of functional and functional monomers. Appropriate selection of monomers reduces emergence of latent functional groups in subsequent array synthesis.

专利号:US-2008274074-A1
优先权日:2005-11-24
标题:Method for Controlled Free Radical Polymerization or Copolymerization of Methacrylic and/or Methacrylate Monomers or Exclusively Methacrylic and/or Methacrylate Copolymers
发明人：COUTURIER JEAN-LUC; GUILLANEUF YOHANN; BERTIN DENIS; GIGMES DIDIOR
权利人:ARKEMA FRANCE
摘要:The invention relates to a method for the polymerization of one or more methacrylate and/or methacrylic monomers, for the synthesis of methacrylate or methacrylic polymers or of exclusively methacrylic and/or methacrylate copolymers, comprising a step of bringing said monomer(s) into contact with one at least of the compounds of formula (I) and (II) below: n n n n n n n n n n in which:n R 1 and R 2 may represent a phenyl group, R 3 and R 4 may together form an â•?N-phenyl group, Z represents a group of formula —CR 8 R 9 R 10 , in which R 8 and R 9 may represent methyl groups and R 10 may represent a —COO-phenyl group.

专利号:US-8338621-B2
优先权日:2005-12-21
标题:Process for the preparation of 2-oxo-1-pyrrolidine derivatives
发明人：SURTEES JOHN; BOUVY DIDIER; THOMAS ANTOINE; COMBRET YVES; FRANK MICHAEL; SCHMIDT GUNTHER; DUCHENE GUY
权利人:SURTEES JOHN; BOUVY DIDIER; THOMAS ANTOINE; COMBRET YVES; FRANK MICHAEL; SCHMIDT GUNTHER; DUCHENE GUY; UCB SA
摘要:The present invention relates to alternative processes for the preparation of 2-oxo-1-pyrrolidine derivatives of formula (I) n n n n n n n n n n Particularly, the present invention relates to alternative processes for the synthesis of levetiracetam, brivaracetam and seletracetam.

专利号:US-8192762-B2
优先权日:2005-06-01
标题 :Preparation of soluble and colloidal molecularly imprinted polymers by living polymerization
发明人：KARIM KHALKU; PILETSKY SERGEY ANATOLIYOVICH; PILETSKA OLENA VOLODIMIRIVNA; TURNER ANTHONY PETER FRANCIS; CHIANELLA IVA; GUERRIERO ANTONIO RICARDO LEONARDO
权利人:KARIM KHALKU; PILETSKY SERGEY ANATOLIYOVICH; PILETSKA OLENA VOLODIMIRIVNA; TURNER ANTHONY PETER FRANCIS; CHIANELLA IVA; GUERRIERO ANTONIO RICARDO LEONARDO; UNIV CRANFIELD
摘要:The present invention describes a method for synthesis of relatively low molecular weight imprinted polymers using living polymerization, and their application in analytical chemistry, pharmacology, medicine and the food industry. Specifically the low-molecular weight polymers are synthesized by the polymerization of functional monomers in the presence of a template, such as a biological receptor, enzyme, nucleic acid, cell, virus, microorganism, tissue sample or drug using living initiator. The conditions of living polymerization ensure a relatively small size of synthesized molecules. Synthesized in this way molecules (dimers, oligomers, polymers, or their mixture) have a higher affinity to the template than the original monomers and can rebind it in vitro and/or in vivo. As a further aspect of the present invention, polymers synthesized as described above can be used as drugs in pharmacology and medicine, as receptor-specific ligands in analytical chemistry (sensors, assays), and for separations in the biotechnology, pharmaceutical and food industries.

专利号:US-8268936-B2
优先权日:2005-01-04
标题:Synthesis of hybrid block copolymers and uses thereof
发明人：BREITENKAMP KURT; SILL KEVIN N
权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC
摘要:The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and methods of preparing the same.