CAS: 2104-19-0; Monomethyl Azelate

该化合物是被归类为酯的有机化合物,来自醋酸和甲醇,具有长碳链,具有其特性.该物质一般是无色的,淡黄色液体,有温味.已知甲酸盐的挥发性低,沸点相对高,在不同条件下稳定.它溶于有机溶剂,但因其疏水性质,溶解于水中.该化合物经常用于生产表面活性剂,催化剂和作为其他化学品合成的中间体.此外,它具有良好的热稳定性,可用于需要无毒性和生物降解成分的配方.安全数据表明,应小心处理该物质,如许多有机化学品一样,以避免皮肤和眼刺激.

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上下游产品

methanol azelaic acid Dimethyl azelate 9-cis,11-trans,13-cis-°Ctadecatrienoic acidisolauric acid (S)-10-methyldodecanoic acid heptadecanoic acid nonanoic acid

合成工艺路线路线简述

    油酸甲酯置于溶剂黄146体系中,化学反应生成壬二酸氢甲酯
    参考文献:Davies; Adams,Journal Of The American Chemical Society,1928,Vol. 50,P. 1754
    标题:Davies; Adams,Journal Of The American Chemical Society,1928,Vol. 50,P. 1754

    海关参考信息

    专利信息


    专利号:US-2025162968-A1
    优先权日:2022-02-02
    标 题 :Method for Producing Ionizable Lipids or Intermediates for the Synthesis of Such Lipids
    发明人:ATMURI N D PRASAD; ARNOLD DEAGLAN; SAADATI FARIBA; KUREK DANIEL; KULKARNI JAYESH; WITZIGMANN DOMINIK; CIUFOLINI MARCO A
    权利人:NANOVATION THERAPEUTICS INC
    摘要:The present disclosure provides a method for producing one or more intermediates for the synthesis of one or more ionizable lipids, the method comprising: (i) producing a beta-ketoacid by reacting a cyclic ester, a terminal hydroxyester or a derivative thereof, a dicarboxylic acid half ester, or an acid chloride derivative of the dicarboxylic acid half ester, in a condensation reaction, thereby producing the beta-ketoacid or a beta-ketoester that is hydrolyzed to produce the beta-ketoacid; and (ii) decarboxylating the beta-ketoacid, thereby producing the one or more intermediates, wherein the one or more intermediates have a structure that may be defined by Formula A. Further provided is a method for producing ionizable lipid from the intermediate comprising adding an ionizable head group moiety to (a) a ketone group of one or more intermediates having the structure that may be defined by Formula A; or (b) a corresponding alcohol of the intermediate.

    专利号:US-8030496-B2
    优先权日:2005-02-17
    标 题:Intermediate compound for synthesis of viridiofungin a derivative
    发明人:KATO TATSUYA; KIMURA NOBUAKI; MIZUTANI AKEMI; MAKINO TOSHIHIKO; KAWASAKI KENICHI; FUKUDA HIROSHI; KOMIYAMA SUSUMU; TSUKUDA TAKUO
    权利人:CHUGAI PHARMACEUTICAL CO LTD
    摘要:A method whereby a compound having HCV replication inhibitory activity and desired optical activity can be synthesized selectively and at high yield in a small number of steps by using a compound having a specific chiral auxiliary as a starting compound is provided. n A compound represented by the formula (1-8): n n n n n n n n n n n n wherein Y represents a group represented by the following formula: n n n n n n n n n n n n n n n n Q represents a protected carbonyl group; D represents —(CH 2 ) m —R′, etc.; and n represents an integer of 0 to 10.

    专利号:US-8703993-B2
    优先权日:2011-03-25
    标题 :Synthesis of alpha,omega-dicarboxylic acids and esters thereof from unsaturated fatty acid derivatives
    发明人:HANNEN PETER; HAEGER HARALD; ROOS MARTIN
    权利人:HANNEN PETER; HAEGER HARALD; ROOS MARTIN; EVONIK DEGUSSA GMBH
    摘要:A process for preparing an alpha, omega-dicarboxylic acid or an ester thereof, which includes (a) subjecting at least one unsaturated fatty acid or fatty acid derivative to ozonolysis to obtain an ozonolysis reaction mixture; and (b) oxidizing the ozonolysis reaction mixture with an oxidizing agent in the presence of an acid catalyst to obtain an oxidized reaction mixture comprising at least one alpha, omega-dicarboxylic acid or ester; wherein the process is performed using a solvent and the acid catalyst has a pKa of less than or equal to zero, as measured at 25° C.

    专利号:WO-2023147657-A1
    优先权日:2022-02-02
    标题 :Method for producing ionizable lipids or intermediates for the synthesis of such lipids

    专利号:US-2014256904-A1
    优先权日:2011-08-15
    标 题:Biotechnological synthesis process of omega-functionalized carbon acids and carbon acid esters from simple carbon sources
    发明人:SCHAFFER STEFFEN; DECKER NICOLE; GIELEN JASMIN; HAEGER HARALD; HAAS THOMAS; POETTER MARKUS; HENNEMANN HANS-GEORG; WESSEL MIRJA; VOLLAND MICHAEL
    权利人:SCHAFFER STEFFEN; DECKER NICOLE; GIELEN JASMIN; HAEGER HARALD; HAAS THOMAS; POETTER MARKUS; HENNEMANN HANS-GEORG; WESSEL MIRJA; VOLLAND MICHAEL; EVONIK DEGUSSA GMBH
    摘要:The subject of the invention is a biotechnological process for the production of ω-functionalized carboxylic acids and of ω-functionalized carboxylate esters from simple carbon sources.

    专利号:EP-4472941-A1
    优先权日:2022-02-02
    标 题 :Method for producing ionizable lipids or intermediates for the synthesis of such lipids
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    合成参考文献


    参考文献:10.1021/ol026145n
    摘要:Gung BW, Dickson H. Total synthesis of (-)-minquartynoic acid: an anti-cancer, anti-HIV natural product. Org Lett. 2002 Jul 25;4(15):2517–9. doi: 10.1021/ol026145n.
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