CAS: 31938-11-1; O-Tritylhydroxylamine

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CAS号31938-10-0 2-trityloxyisoi... | CAS号76-83-5 三苯基氯甲烷 | CAS号10229-67-1 Benzaldehyde,O-...

三苯基氯甲烷置于hydrazine Hydrate,三乙胺体系中,用 甲醇,二氯甲烷,氯仿 作为反应溶剂,化学反应 3.0H,反应生成 O-三苯甲基羟胺
参考文献:4-羟基-2-甲基环戊-2-烯-1-酮及其e-O-三苯甲基肟动力学动力学拆分的研究
标题:4-羟基-2-甲基环戊-2-烯-1-酮及其e-O-三苯甲基肟动力学动力学拆分的研究
摘要:研究了通过金属络合物诱导的消旋和南极假丝酵母脂肪酶介导的模型羟基酮的对映选择性乙酰化的动力学动力学拆分:4-羟基-2-甲基环戊-2-烯-1-酮及其选择的衍生物.[rucl 2(cymene)] 2络合物三乙胺有效地影响了羟基酮的外消旋作用,而shvo的催化剂引发了分子内的氧化还原过程.在与[rucl 2(cymene)] 2外消旋相容的条件下,南极衣藻的4-羟基-2-甲基环戊-2-烯-1-酮的动力学拆分未能达到效率阈值.但是,其o的动态动力学分辨率[rucl 2(cymene)] 2-三乙胺和南极弯曲杆菌脂肪酶-乙酸异丙烯酯的组合成功实现了对苯三甲肟.
DOI:10.1016/j.Tet.2016.06.047

专利信息

专利号:US-5849951-A
优先权日:1995-03-01
标题 :Synthesis of carboxylic and hydroxamic acid derivatives
发明人：FLOYD CHRISTOPHER DAVID; WHITTAKER MARK
权利人:BRITISH BIOTECH PHARM
摘要:PCT No. PCT/GB96/00467 Sec. 371 Date Aug. 29, 1997 Sec. 102(e) Date Aug. 29, 1997 PCT Filed Mar. 1, 1996 PCT Pub. No. WO96/26918 PCT Pub. Date Sep. 6, 1996A method for the preparation of a compound of formula (I) (I) wherein X is hydrogen; Y is (i) a group -CO2R5 wherein R5 is a carboxyl protecting group or (ii) a group -CONR6OR7 wherein R6 is an amino protecting group and R7 is a hydroxyl protecting group; and S1, S2, S3 and S4 each represent covalently bound moieties which are substantially non-reactive with the reaction components (II), (III), or (IV) defined below, which method comprises causing the co-condensation in a liquid organic medium of a carboxylic acid reaction component of formula (II); an aldehyde of formula (IIIA); ammonia; and an isonitrile reaction component of formula (IV): (II) (IIIA) (IV) wherein Y, S1, S2, S3 and S4 are as defined with respect to formula (I).

专利号:US-6541276-B2
优先权日:1996-10-28
标题:Methods for solid-phase synthesis of hydroxylamine compounds and derivatives and combinatorial libraries thereof
发明人：PATEL DINESH V; NGU KHEHYONG
权利人:VERSICOR INC
摘要:A novel method for generating hydroxylamine, hydroxamic acid, hydroxyurea, and hydroxylsulfonamide compounds is disclosed. The method involves the nucleophilic attack of an alkoxyamine on a suitable solid phase support. Techniques of combinatorial chemistry can then be applied to the immobilized alkoxyamine to generate a diverse set of compounds. Cleavage of the compounds from the support yields a library of hydroxylamine or hydroxylamine derivative compounds, which can be screened for biological activity (e.g., inhibition of metalloproteases).

专利号:US-7166729-B2
优先权日:2001-08-02
标 题:Process for the preparation of 5-substituted isobenzofurans
发明人：DALL ASTA LEONE; COTTICELLI GIOVANNI
权利人:INFOSINT SA
摘要:There is described a process for the preparation of citalopram and of its pharmaceutically acceptable salts, which comprises treating a 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5 isobenzofurancarbaldoxime, O-substituted preferably with a diphenylmethyl or triphenylmethyl group, with formic-acetic anhydride. Furthermore, the total synthesis of citalopram, as free base or in form of its pharmaceutically acceptable salt, starting from 5-formylphthalide is described.

专利号:WO-9626918-A1
优先权日:1995-03-01
标题:Synthesis of carboxylic and hydroxamic acid derivatives

专利号:WO-9818754-A1
优先权日:1996-10-28
标 题:Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof

专利号:US-5491167-A
优先权日:1993-01-29
标题 :Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses
发明人：ISHIHARA SADAO; KOGEN HIROSHI; KOGA TEIICHIRO; KITAZAWA EIICHI; SERIZAWA NOBUFUSA
权利人:SANKYO CO
摘要:Compounds of formula (I): ##STR1## and their salts and esters have the ability to inhibit the synthesis of cholesterol, and can thus be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.